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New nanosized sensor records the electrical activity of spinal neurons

Implantable technologies have significantly improved our ability to study and even modulate the activity of neurons in the brain, but neurons in the spinal cord are harder to study in action.

11 Jul 2024

Heparan-sulfate proteoglycans found to influence Alzheimer's cell pathology

The impact of heparan-sulfate-modified proteoglycans (HSPGs) on Alzheimer's disease-associated pathways.

5 Jul 2024

Single-cell profiling of lateral septum neurons reveals LSEsr1's role in METH addiction

Recently, a research team led by Dr. ZHU Yingjie from the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences has published a study in Neuron, the study presents a comprehensive transcriptional profile of the lateral septum (LS) at the single-cell level, elucidating the spatial distribution of its major neuronal types.

3 Jul 2024

Study finds promising new target for the treatment of Alzheimer's disease

A class of proteins that regulates cell repair and enhances cell growth-signaling systems could be a promising new target for the treatment of Alzheimer's and other neurodegenerative diseases, according to a new study led by researchers at Penn State.

2 Jul 2024

NIH scientists uncover brain circuitry behind face detection in primates

Scientists at the National Institutes of Health (NIH) have uncovered a brain circuit in primates that rapidly detects faces.

2 Jul 2024

Study identifies key neurons controlling threat response and escape in mice

Neuroscientists have discovered how the brain bidirectionally controls sensitivity to threats to initiate and complete escape behaviour in mice. These findings could help unlock new directions for discovering therapies for anxiety and post-traumatic stress disorder (PTSD).

27 Jun 2024

Nonhuman primate model reveals early-stage Alzheimer’s disease progression

Research in nonhuman primates is opening the possibility of testing treatments for the early stages of Alzheimer’s and similar diseases, before extensive brain cell death and dementia set in.

26 Jun 2024

Study reveals brain health benefits of intermittent fasting and healthy diet plans

Researchers from Johns Hopkins Medicine and the National Institutes of Health's National Institute on Aging say their study of 40 older adults with obesity and insulin resistance who were randomly assigned to either an intermittent fasting diet or a standard healthy diet approved by the U.S. Department of Agriculture (USDA) offers important clues about the potential benefits of both eating plans on brain health.

25 Jun 2024

Researchers characterize thalamic and cortical neurons that respond to stimulation of the ocular surface

Nerve fibers on the eye surface are involved in many relevant physiological processes, from detecting and transmitting external stimuli to maintaining the integrity of the cornea.

25 Jun 2024

New study in rhesus macaques offers early intervention window for Alzheimer's

Research in nonhuman primates is opening the possibility of testing treatments for the early stages of Alzheimer's and similar diseases, before extensive brain cell death and dementia set in.

24 Jun 2024

KU researchers uncover role of Src gene in nervous system development

Many people are familiar with oncogenes - genes long known to be involved in cancers in humans, such as the gene "Src."

24 Jun 2024

Restoring youthful TERT levels reverses aging phenotypes in preclinical models

Researchers at The University of Texas MD Anderson Cancer Center have demonstrated that therapeutically restoring 'youthful' levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical models.

21 Jun 2024

High-fat diet triggers anxiety in male rats through gut-brain axis disruption

Researchers investigate the impact of a high-fat diet on gut microbiome diversity and its effects on anxiety-related symptoms.

20 Jun 2024

Study identifies drug target to prevent autonomic dysfunction after spinal cord injury

In response to stressful or dangerous stimuli, nerve cells in the spinal cord activate involuntary, autonomic reflexes often referred to as "fight or flight" responses.

12 Jun 2024

New AARF-D award supports Temple researchers to explore synapse function in the aging brain

Late-life depression is a major risk factor for Alzheimer's disease, in particular because it accelerates progression from mild cognitive impairment to dementia.

12 Jun 2024

Johns Hopkins researchers discover how epilepsy drug modulates brain activity

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius - nearly twice as cold as the coldest places in Antarctica - scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

10 Jun 2024

Key protein orco crucial for ant olfactory neuron survival and social behavior

While smell plays a considerable role in the social interactions of humans - for instance, signaling fear or generating closeness - for ants, it is vitally important.

7 Jun 2024

Novel CMOS sensor captures fast and subtle neural voltage fluctuations

Neurons communicate electrically so to understand how they produce brain functions such as memory, neuroscientists must track how their voltage changes - sometimes subtly - on the timescale of milliseconds.

7 Jun 2024

Mechanisms of aversive learning: How negative experiences shape neural circuits

'I'm not gonna do this again', we often say when faced with negative feedback, adverse effects, or disappointing outcomes. Thus, we attempt to learn from such negative experiences.

7 Jun 2024

Curcumin nanoparticles show promise in treating neurodegenerative diseases

Review demonstrates curcumin's neuroprotective effects in neurodegenerative diseases, enhancing its potential through innovative nanoparticle formulations. This advancement could significantly improve treatments for diseases like Parkinson's, Alzheimer's, and Multiple Sclerosis.

6 Jun 2024