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New biomarkers offer hope for early detection and prevention of Alzheimer's

The failure to diagnose Alzheimer's disease, the most common form of dementia in the elderly, at an early stage of molecular pathology is considered a major reason why treatments fail in clinical trials. Previous research to molecularly diagnose Alzheimer's disease yielded "A/T/N" central biomarkers based on the measurements of proteins, β-amyloid ("A") and tau ("T"), and "N" encompassing neurodegeneration. A/T/N can be measured in brain tissue, by in vivo brain imaging techniques, and by analysis of cerebrospinal fluid and plasma.

18 Sep 2024

Brain-inspired materials pave the way for efficient computing

A team of researchers from Texas A&M University, Sandia National Lab - Livermore, and Stanford University are taking lessons from the brain to design materials for more efficient computing.

16 Sep 2024

Scientists develop selective therapy for tau tangles

Scientists have developed new potential therapies that selectively remove aggregated tau proteins, which are associated with Alzheimer's disease, and improve symptoms of neurodegeneration in mice.

14 Sep 2024

New AI method simulates neuronal activity from connectome data

With maps of the connections between neurons and artificial intelligence methods, researchers can now do what they never thought possible: predict the activity of individual neurons without making a single measurement in a living brain.

12 Sep 2024

Neuroscientists map brain-wide decision-making process in mice

Neuroscientists have revealed how sensory input is transformed into motor action across multiple brain regions in mice.

12 Sep 2024

Concept neurons and location cells play key roles in memory formation

Certain nerve cells in the brain become active whenever they are confronted with different images or the name of a specific person or the identity of an object. They are highly selective and do not react to other people or objects.

12 Sep 2024

Genetics of Alzheimer's disease and dementia in African populations presented at Nairobi conference

Regions of the genome associated with Alzheimer's disease and dementia in African populations will be presented at the Future of Dementia in Africa conference on September 11-12, 2024.

12 Sep 2024

Study links protein increases to cognitive improvement in Alzheimer's

A study published in the journal Brain shows that increases in protein levels with new Alzheimer's drugs can explain the slowing of cognitive impairment at least as well as the reduction in amyloid plaques.

11 Sep 2024

Study unveils dynamic brain architecture through advanced fMRI techniques Neuroscientists In Spain ...

Researchers from the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) of Elche, along with a team from the Transylvanian Institute of Neuroscience (Romania), and in collaboration with experts from the Universitat Politècnica de València, have developed an innovative approach to studying brain connections using functional magnetic resonance imaging (fMRI).

11 Sep 2024

New target identified for potential ALS therapy

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects motor neurons.

10 Sep 2024

A fluorescent probe for studying serotonin in depression models

Serotonin in depression is highly relevant in diagnosis, treatment, and drug development. To better study this area, a Chinese team has now developed a fluorescent probe for imaging processes that is highly sensitive and selective toward serotonin.

6 Sep 2024

Hybrid neuron-glia cells found in glioma may impact tumor growth

Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital have uncovered a new cell type in the human brain.

5 Sep 2024

New insights into stiff-person syndrome, advancing diagnosis and treatment

Research explores the complexities of diagnosing and treating stiff-person syndrome, emphasizing the uncertain role of GAD antibodies and the promise of novel therapies.

5 Sep 2024

CDK4/6 inhibitors show promise for pediatric high-grade glioma treatment

CDK4/6 inhibitors, which are already FDA approved for the treatment of other forms of cancer, show early signs of promise in the treatment of a subtype of pediatric high-grade glioma, according to new research from Dana-Farber Cancer Institute and the Institute of Cancer Research in London.

3 Sep 2024