Pathophysiology News and Research

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Possibility of the first fluid biomarker that reflects brain pathology in primary tauopathies

Addressing this gap in research, a recent Nature Medicine study hypothesized that 4R isoform-specific MTBR-tau species accumulate in the patient’s brain of specific subtypes of 4R tauopathies.

28 Nov 2022

The distinct pathophysiology of ‘SuperAger’ brains

Superagers are adults over the age of 80 who have a superior memory capacity that resembles that of middle-aged adults.

27 Nov 2022

Biologic therapy for IBD patients through a financial assistance program could have superior outcomes

Patients with inflammatory bowel diseases (IBD) who required treatment with biologic therapies and were enrolled in a financial assistance program were less likely to need surgery after starting medication than those not enrolled in a program, a study by UT Southwestern researchers found.

23 Nov 2022

Study explores link between dynamic changes in metabolic syndrome and risk of gout

In a study published in Arthritis & Rheumatology that included nearly 1.3 million men aged 20–39 years who participated in three serial health check-ups at two-year intervals, men with metabolic syndrome (MetS) and those who developed MetS - especially those with the MetS components of elevated triglycerides and abdominal obesity - had higher risks of developing gout.

23 Nov 2022

The binding and functional serologic responses to COVID-19 vaccination in children with history of MIS-C

Researchers evaluated the serological responses elicited by COVID-19 vaccinations in children who developed MIS-C following a previous SARS-CoV-2 infection.

23 Nov 2022

Omicron BA.2 causes more symptoms and a greater disruption to daily life

In a recent study published in the Nature Communications journal, researchers monitored the changing symptom profiles associated with different severe acute respiratory syndrome CoV-2 (SARS-CoV-2) variants, especially Omicron subvariants BA.1 and BA.2.

16 Nov 2022

Ketogenic diet may show more promising results than Mediterranean diets in short-term type 2 diabetes management

Researchers evaluated the short-term impact of the very-low-calorie ketogenic diet (VLCKD) and Mediterranean diet (MD) on the gut microbiota (GM) of obese patients with new-onset type II diabetes (T2DM).

15 Nov 2022

Do SSRIs lower the risk of long COVID?

Researchers conducted a retrospective study to determine whether SSRIs with immunomodulatory and antiplatelet properties can decrease the risk of post-acute sequelae of COVID-19 (PASC).

15 Nov 2022

Multinational consensus to end COVID-19 pandemic

A new study recommended specific actions to end the coronavirus disease 2019 (COVID-19) pandemic.

7 Nov 2022

Survival rates increased among children who experienced in-hospital cardiac arrest in the last 20 years

Among children who experienced in-hospital cardiac arrest in the last 20 years, survival rates have increased significantly.

31 Oct 2022

Smartphone code blue notification may accelerate response to in-hospital cardiac arrest

Sixty seconds can make or break the outcome of a hospital "code blue" or cardiac arrest response. New research found a hospital code response team rushing to a patient in cardiac arrest may arrive at least one minute quicker and may also lead to better patient outcomes with the use of a smartphone emergency code notification system that activates the team through text messages.

31 Oct 2022

ICU evaluation before cardiac arrest improves survival rates by 15% among Black people

Although racial disparities in survival after in-hospital cardiac arrest among Black and white people are known, both groups had similar chances of receiving an intensive care unit (ICU) evaluation before a cardiac arrest.

31 Oct 2022

CPR training for people in public housing communities may help improve cardiac arrest survival rates

Of all out-of-hospital cardiac arrests in residential areas of Vienna and Copenhagen from 2016-2021, one-third of those cardiac arrests occurred in public housing communities.

31 Oct 2022

Study refutes the nicotinic hypothesis of SARS-CoV-2 infection mechanism

A new study confirmed that the SARS-CoV-2 spike protein does not bind to human AChR’s orthosteric sites, nor does it compete with ACh, choline, or nicotine.

28 Oct 2022

Researchers study the effects of alcohol intake and seek better treatment for alcoholic pancreatitis

Many alcoholic pancreatitis patients continued drinking during COVID-19. University of Miami Miller School of Medicine researchers study the effects of continued alcohol intake and seek better treatment for alcohol-associated pancreatic disease.

24 Oct 2022

Pathophysiological mechanisms of COVID-19-related endothelial dysfunction and potential therapies

Researchers discussed the pathophysiological mechanisms of endothelial dysfunction associated with severe coronavirus disease 2019 (COVID-19) and commented on the potential therapeutic strategies to treat endothelial damage and coagulopathy related to COVID-19.

19 Oct 2022

Exploring epigenetic modifications and the use of vitamin D therapy in COVID-19

Researchers examined the role of epigenetic modifications of the host cell gene expression in determining the pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and explored the use of vitamin D as a therapeutic agent against coronavirus disease 2019 (COVID-19).

19 Oct 2022

High immune protein levels predict both heart failure and death

For years, cardiologists have zeroed in on a hormone called BNP as a gold standard to determine if patients with heart failure are at risk of severe illness or death. It's released by the heart in response to when the cardiac tissue stretches due to pressure.

17 Oct 2022

A rare case of Hashimoto encephalopathy after COVID vaccination

In a recent ‘Letter to the Editor’ published in the English edition of the journal Neurologandiacute, researchers reported the rare occurrence of Hashimoto encephalopathy in a recipient of the (COVID-19) vaccine Spikevax. Spikevax, research name mRNA-1273, is a COVID-19 vaccine based on the messenger ribonucleic acid (mRNA) technology.

16 Oct 2022

COVID-19 vaccine may protect pregnant women from SARS-CoV-2 placentitis and stillbirth

Stillbirth is a recognized complication of COVID-19 in pregnant women caused by harmful changes to the placenta induced by the virus.

12 Oct 2022

Pathophysiology News and Research

Possibility of the first fluid biomarker that reflects brain pathology in primary tauopathies

The distinct pathophysiology of ‘SuperAger’ brains

Biologic therapy for IBD patients through a financial assistance program could have superior outcomes

Study explores link between dynamic changes in metabolic syndrome and risk of gout

The binding and functional serologic responses to COVID-19 vaccination in children with history of MIS-C

Omicron BA.2 causes more symptoms and a greater disruption to daily life

Ketogenic diet may show more promising results than Mediterranean diets in short-term type 2 diabetes management

Do SSRIs lower the risk of long COVID?

Multinational consensus to end COVID-19 pandemic

Survival rates increased among children who experienced in-hospital cardiac arrest in the last 20 years

Smartphone code blue notification may accelerate response to in-hospital cardiac arrest

ICU evaluation before cardiac arrest improves survival rates by 15% among Black people

CPR training for people in public housing communities may help improve cardiac arrest survival rates

Study refutes the nicotinic hypothesis of SARS-CoV-2 infection mechanism

Researchers study the effects of alcohol intake and seek better treatment for alcoholic pancreatitis

Pathophysiological mechanisms of COVID-19-related endothelial dysfunction and potential therapies

Exploring epigenetic modifications and the use of vitamin D therapy in COVID-19

High immune protein levels predict both heart failure and death

A rare case of Hashimoto encephalopathy after COVID vaccination

COVID-19 vaccine may protect pregnant women from SARS-CoV-2 placentitis and stillbirth

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