Metrion Biosciences and The KCNC1 Foundation Collaborate on New Ion Channel Modulators

Metrion Biosciences Limited (“Metrion”), the specialist ion channel contract research and drug discovery company, and The KCNC1 Foundation, a not-for-profit organisation focused on the development of a treatment for an ultra rare genetic disorder, today announced a collaboration to progress a hit identification research project for small molecule modulators of the potassium ion channel Kv3.1, targeting KCNC1-related disorders.

Metrion Biosciences and The KCNC1 Foundation Collaborate on New Ion Channel Modulators

Image Credit: UfaBizPhoto/Shutterstock.com

Variants of the KCNC1 gene impact Kv3.1 potassium channel function, resulting in neurodevelopmental disorders which can include progressive myoclonic epilepsy (PME) and developmental epileptic encephalopathy (DEE). Symptoms of KCNC1 disorder include seizures during infancy, vision impairment, developmental delay, intellectual disability and many others. The collaboration is focused on the identification of small molecule modulators of the variant potassium ion channel, Kv3.1 as a potential therapeutic strategy for KCNC1-related disorders, identified as being the cause of KCNC1 related DEE. Metrion will develop cell lines for both wild type and variant Kv3.1, to establish a fluorescence-based screen using FLIPR® Penta, a high-throughput cellular screening system. The high-throughput screen will then be used to identify novel inhibitors or activators of Kv3.1 mutant channels.

The KCNC1 Foundation was created by the parents of a child diagnosed with KCNC1-related DEE to support research aimed at accelerating the development of a cure, as well as to raise awareness to identify and connect patients and provide support for families.

We are very excited to collaborate with Metrion on the possibility of identifying a potential therapeutic for children with KCNC1-related disorder. This is our first step of many to address the pathophysiology of the disorder, to give individuals suffering the opportunity to reach their full potential.” Stephanie Telesca, Co-Founder of The KCNC1 Foundation, commented. “We welcome any contributions toward The KCNC1 Foundation as we work hard to pave a path towards a cure.”

I would like to thank The KCNC1 Foundation for choosing Metrion to progress this discovery research programme. Our team looks forward to helping the Foundation accomplish its goal to deliver efficacious treatments to patients as quickly as possible.

Dr. Andrew Southan, Metrion’s Chief Executive

For more information, please visit www.metrionbiosciences.com and www.kcnc1.org.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Metrion Biosciences Limited. (2022, December 07). Metrion Biosciences and The KCNC1 Foundation Collaborate on New Ion Channel Modulators. News-Medical. Retrieved on November 02, 2024 from https://www.news-medical.net/news/20221207/Metrion-Biosciences-and-The-KCNC1-Foundation-Collaborate-on-New-Ion-Channel-Modulators.aspx.

  • MLA

    Metrion Biosciences Limited. "Metrion Biosciences and The KCNC1 Foundation Collaborate on New Ion Channel Modulators". News-Medical. 02 November 2024. <https://www.news-medical.net/news/20221207/Metrion-Biosciences-and-The-KCNC1-Foundation-Collaborate-on-New-Ion-Channel-Modulators.aspx>.

  • Chicago

    Metrion Biosciences Limited. "Metrion Biosciences and The KCNC1 Foundation Collaborate on New Ion Channel Modulators". News-Medical. https://www.news-medical.net/news/20221207/Metrion-Biosciences-and-The-KCNC1-Foundation-Collaborate-on-New-Ion-Channel-Modulators.aspx. (accessed November 02, 2024).

  • Harvard

    Metrion Biosciences Limited. 2022. Metrion Biosciences and The KCNC1 Foundation Collaborate on New Ion Channel Modulators. News-Medical, viewed 02 November 2024, https://www.news-medical.net/news/20221207/Metrion-Biosciences-and-The-KCNC1-Foundation-Collaborate-on-New-Ion-Channel-Modulators.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Metrion Biosciences and International Scientific Consortium publish data and new recommendations for in vitro risk assessment of the cardiac safety of new medicines