Efficacy News and Research

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Experimental drug more effective than existing FDA-approved medications for ALS

New research on the experimental drug, NU-9, invented and developed by two Northwestern University scientists to treat ALS (amyotrophic lateral sclerosis), shows it is more effective than existing FDA-approved drugs for the disease.

17 May 2022

Study investigates COVID-19 vaccination in pregnancy

A new study discusses the risk of COVID-19-related complications in pregnancy and the role of vaccination in reducing this risk.

17 May 2022

Small cell lung cancer subtypes respond differently to chemotherapeutics and targeted drugs

Small cell lung cancer (SCLC) is a malignant disease associated with a particularly high mortality rate. According to a new multicenter study led by MedUni Vienna and conducted in collaboration with researchers from the Czech Republic, Hungary, Slovenia, Sweden and the United States, SCLC can be divided into several subgroups in terms of clinical behavior.

17 May 2022

Researchers explore COVID-19 vaccination in immunocompromised individuals

A new study discusses the safety and efficacy of the COVID-19 vaccination and potential strategies to optimize protection in patients with impaired immunity.

17 May 2022

Inflammation plays a key role in resolving pain

In a recent study published in the journal Science Translational Medicine, researchers explored the mechanisms underlying the transition from acute to chronic low back pain (LBP) by transcriptome-wide analysis of peripheral immune cells from acute LBP patients.

17 May 2022

Broad-spectrum polymeric antivirals against SARS-CoV-2

In a recent study published in the journal Advanced Science, researchers evaluated the potential and applicability of macromolecular viral inhibitors against respiratory viral pathogens.

17 May 2022

Smart bioelectronic pacifier could help monitor babies' electrolytes in NICUs

A wireless, bioelectronic pacifier could eliminate the need for invasive, twice-daily blood draws to monitor babies' electrolytes in Newborn Intensive Care Units or NICUs.

16 May 2022

Artificial proteins as specific and versatile neutralizing binders targeting the spike of SARS-CoV-2

Researchers demonstrated that the biosynthetic proteins called αReps addressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein could be novel SARS-CoV-2 antivirals

13 May 2022

Novel Type 1 diabetes treatment involves pancreatic islet transplant without the need for immunosuppression

In a new study, a team of researchers from the University of Missouri, Georgia Tech and Harvard University has demonstrated the successful use of a novel Type 1 diabetes treatment in a large animal model.

13 May 2022

The potential role of the gut microbiome in modifying patient responses to statin therapy

Researchers discovered strong links between human gut microbiome makeup and statin on- and off-target effects, probably beneficial in medication tailoring.

13 May 2022

The safety, immunogenicity, and efficacy of the mRNA-1273 vaccine in children aged 6-11

In a recent study published in The New England Journal of Medicine, researchers evaluated the safety, immunogenicity, and efficacy of the messenger ribonucleic acid (mRNA)-1273 vaccine in children.

13 May 2022

Multicenter study determines the efficacy of SARS-CoV-2 vaccination against Post-Acute Sequelae of COVID-19

A new study published in Open Forum Infectious Diseases has focused on analyzing the efficacy of COVID-19 vaccination against PASC, utilizing multicentre data across the USA.

13 May 2022

Study explores macromolecular viral entry inhibitors as broad-spectrum first-line antivirals with anti-SARS-CoV-2 activities

Researchers created polystyrene sulfonate with significantly different molar masses, constructed these polymers as an exterior around spherical gold nanoparticles of various sizes to improve multivalency effects, measured antiviral effects of the antivirals on numerous viruses in vitro, and investigated the method of interaction of the leads with SARS-CoV-2 and lentiviral particles.

13 May 2022

Investigating effectiveness of mRNA booster against SARS-CoV-2 Omicron in individuals primed with mRNA or inactivated virus vaccines

Scientists have determined the effectiveness of different vaccination regimens in eliciting humoral immune responses against the SARS-CoV-2 Omicron variant.

13 May 2022

Exploring short-term effectiveness of COVID-19 booster vaccine and stable CD8+ T cell memory after three doses

A new study has longitudinally traced and profiled the CD8+ T cell responses after COVID-19 mRNA booster vaccination.

13 May 2022

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

In a recent study posted to the bioRxiv* preprint server, researchers explored the role of the N-terminal domain (NTD) of the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike (S) protein in SARS-CoV-2 fusion with the host membranes and coronavirus disease 2019 (COVID-19).

12 May 2022

Topical drugs may regress congenital giant nevi and prevent skin cancer

About one in 20,000 infants is born with what's called a congenital giant nevus - a huge, pigmented mole that may cover much of the face and body.

12 May 2022

Penn study finds low uptake of first mutation-targeted bladder cancer drug

The first bladder cancer drug targeting a cancer-driving gene mutation has been used relatively little despite its clear efficacy in a clinical trial, suggests a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

12 May 2022

Cost-effective ovine antibody-based therapy against SARS-CoV-2 infection

A recent study published in the journal Antiviral Research explored alternative sources of polyclonal antibodies against SARS-CoV-2, which would be more cost-effective, amendable to regulatory approval, and widespread use.

12 May 2022

Study could provide a new approach to treating metastatic triple negative breast cancer

Research from the University of Michigan Rogel Cancer Center could provide a new approach to treating an aggressive form of breast cancer.

12 May 2022

Efficacy News and Research

Experimental drug more effective than existing FDA-approved medications for ALS

Study investigates COVID-19 vaccination in pregnancy

Small cell lung cancer subtypes respond differently to chemotherapeutics and targeted drugs

Researchers explore COVID-19 vaccination in immunocompromised individuals

Inflammation plays a key role in resolving pain

Broad-spectrum polymeric antivirals against SARS-CoV-2

Smart bioelectronic pacifier could help monitor babies' electrolytes in NICUs

Artificial proteins as specific and versatile neutralizing binders targeting the spike of SARS-CoV-2

Novel Type 1 diabetes treatment involves pancreatic islet transplant without the need for immunosuppression

The potential role of the gut microbiome in modifying patient responses to statin therapy

The safety, immunogenicity, and efficacy of the mRNA-1273 vaccine in children aged 6-11

Multicenter study determines the efficacy of SARS-CoV-2 vaccination against Post-Acute Sequelae of COVID-19

Study explores macromolecular viral entry inhibitors as broad-spectrum first-line antivirals with anti-SARS-CoV-2 activities

Investigating effectiveness of mRNA booster against SARS-CoV-2 Omicron in individuals primed with mRNA or inactivated virus vaccines

Exploring short-term effectiveness of COVID-19 booster vaccine and stable CD8+ T cell memory after three doses

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

Topical drugs may regress congenital giant nevi and prevent skin cancer

Penn study finds low uptake of first mutation-targeted bladder cancer drug

Cost-effective ovine antibody-based therapy against SARS-CoV-2 infection

Study could provide a new approach to treating metastatic triple negative breast cancer

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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