Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

African sleeping sickness parasite's previously unrecognized extreme social behavior discovered

Long considered a freewheeling loner, the Trypanosoma brucei parasite responsible for African sleeping sickness has revealed a totally unexpected social side, opening a potential chink in the behavioral armor of this and other supposedly solitary human parasites, according to research presented at the American Society for Cell Biology's 50th Annual Meeting in Philadelphia.

15 Dec 2010

Study broadens understanding of role of IDH1 and IDH2 mutations in AML

Agios Pharmaceuticals, the leading biopharmaceutical company focused on discovering and developing novel drugs in the rapidly emerging field of cancer metabolism, today announced the publication of a paper in Cancer Cell that illuminates the mechanism by which 2-hydroxyglutarate (2HG), and the mutations in the metabolic genes IDH1 and IDH2 that produce it, may be driving the growth of tumors in patients with acute myeloid leukemia (AML).

15 Dec 2010

Tumor suppressor p53 may serve as 'Guardian against Genome Reprogramming'

A close collaboration between researchers at the Salk Institute for Biological Studies and the Institute for Advanced Study found that the tumor suppressor p53, long thought of as the "Guardian of the Genome," may do more than thwart cancer-causing mutations. It may also prevent established cancer cells from sliding toward a more aggressive, stem-like state by serving as a "Guardian against Genome Reprogramming."

15 Dec 2010

Genes predict survival time, potential new treatments for patients with non-small cell lung cancer

Researchers at UT Southwestern Medical Center have discovered sets of genes active in cancer cells and normal tissue that predict survival time and potential new treatments for patients with non-small cell lung cancer.

15 Dec 2010

Response Genetics presents two gene expression analysis for personalized cancer tharapy selection

Response Genetics Inc., a company focused on the development and sale of molecular diagnostic tests for cancer, announced the results of two separate analyses at national medical conferences.

14 Dec 2010

Genomic Health announces results of Oncotype DX test in early-stage breast cancer patients

"We provide optimal care to breast cancer patients when we treat the underlying biology of their individual tumors," said Steven Shak, MD, chief medical officer of Genomic Health.

14 Dec 2010

Elsevier announces special Issue on Fetal Alcohol Spectrum Disorders

Elsevier Inc., the world's leading publisher of scientific, technical and medical information, announced today that Alcohol has published a special year-end double issue on Fetal Alcohol Spectrum Disorders (FASD). It fills an urgent need to bring the widest possible readership current perspectives on using new research methods to improve identification and diagnosis of offspring at risk for FASD and its associated brain damage and behavioral dysfunction.

13 Dec 2010

Depression in mothers during pregnancy associated with higher levels of stress hormones in children

The cocktail of hormones cascading through depressed mothers' bodies may play an important role in the development of their unborn children's brains.

13 Dec 2010

Prostate cancer study identifies 295 genes associated with clinical recurrence following radical prostatectomy

Genomic Health, Inc. today announced the first results of a large prostate cancer study that identified 295 genes strongly associated with clinical recurrence following radical prostatectomy. Top-line findings from this study, which applied the same RT-PCR technology used in Genomic Health's Oncotype DX® breast and colon cancer tests, will be presented today at the Society for Urologic Oncology (SUO) annual meeting.

13 Dec 2010

Obesity is associated with worse outcomes in patients with ER-positive/HER2-negative disease

Obesity was associated with worse overall and disease-free survival in women with operable breast cancer treated with adjuvant chemotherapy, but for the first time, researchers observed this finding in only a specific subset of patients - those with estrogen receptor (ER)-positive/HER2-negative disease.

10 Dec 2010

Walter and Eliza Hall Institute researcher awarded 2011 Gani Medal for Human Genetics

Major advances in our understanding of human evolution have seen Walter and Eliza Hall Institute researcher Dr Alicia Oshlack awarded the 2011 Gani Medal for Human Genetics by the Australian Academy of Science.

9 Dec 2010

Medulloblastoma subtypes are separate diseases with different origins

International effort led by St. Jude Children's Research Hospital scientists is expected to fuel development of targeted therapies and aid the search for unique combinations of cells and mutations that lead to other cancers.

8 Dec 2010

ChipDX validates genetic signature for early-stage colon cancer

ChipDX LLC, a New York-based online molecular diagnostics and personalized medicine company, discovered and validated a genetic signature for early-stage colon cancer and is developing an online screening application to enable clinicians to more accurately identify risk of recurrence. In the study, published in the December issue of the British Journal of Cancer, ChipDX demonstrates how the 163-gene signature stratifies colon cancer patients into high- and low-risk groups for recurrence with greater accuracy than current methods.

8 Dec 2010

NanoString secures exclusive worldwide license to develop products for breast cancer intrinsic subtyping

NanoString Technologies, Inc., a privately held life sciences company marketing a complete solution for detecting and counting large sets of target molecules in biological samples, today announced it has secured an exclusive worldwide license from Bioclassifier, LLC to develop in vitro diagnostic and research products for breast cancer intrinsic subtyping.

From NanoString Technologies 7 Dec 2010

Roche introduces X-tremeGENE 9, X-tremeGENE HP reagents

Roche announced today the introduction of two new high-performance DNA transfection reagents for its innovative cellular analysis portfolio for life science research.

7 Dec 2010

HDAC inhibitors may be used to fight against skin cancers

In a study published in the journal Developmental Cell, Sarah Millar PhD, professor of Dermatology and Cell & Developmental Biology at the University of Pennsylvania School of Medicine, and colleagues demonstrate that a pair of enzymes called HDACs are critical to the proper formation of mammalian skin.

7 Dec 2010

Exiqon announces launch of 6th generation of miRCURY LNA microRNA Arrays

Exiqon A/S, a leading supplier of high-value gene expression analysis products, today announced the launch of the 6th generation of miRCURY LNA microRNA Arrays for expression profiling of microRNA from human, mouse and rat.

6 Dec 2010

Pivotal Phase II study data of romidepsin in relapsed PTCL presented at ASH 2010

Celgene International Sàrl today announced that data from a pivotal Phase II, multicenter, international, open-label study of romidepsin (ISTODAX) in progressive or relapsed PTCL following prior systemic therapy were presented at the 52nd American Society of Hematology Annual Meeting.

6 Dec 2010

Seven studies on Oncotype DX breast cancer test to be presented at 33rd CTRC-AACR SABCS

Genomic Health, Inc. today announced that the company will present results from seven studies at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium (SABCS), taking place December 8-12, 2010 at the Henry B. Gonzalez Convention Center.

4 Dec 2010

Clinical studies participated by three investigators to be presented at ASH Annual Meeting and Exposition

US Oncology, Inc., the nation's leading integrated oncology company, announced today that three investigators affiliated with US Oncology Research participated in studies that will be presented orally at the 52nd American Society of Hematology Annual Meeting and Exposition at the Orange County Convention Center in Orlando, Fla. Dec. 4-7. Five other investigators in the US Oncology Research Network participated in a study that will be displayed as a poster during the conference.

4 Dec 2010

Gene Expression News and Research

Further Reading

African sleeping sickness parasite's previously unrecognized extreme social behavior discovered

Study broadens understanding of role of IDH1 and IDH2 mutations in AML

Tumor suppressor p53 may serve as 'Guardian against Genome Reprogramming'

Genes predict survival time, potential new treatments for patients with non-small cell lung cancer

Response Genetics presents two gene expression analysis for personalized cancer tharapy selection

Genomic Health announces results of Oncotype DX test in early-stage breast cancer patients

Elsevier announces special Issue on Fetal Alcohol Spectrum Disorders

Depression in mothers during pregnancy associated with higher levels of stress hormones in children

Prostate cancer study identifies 295 genes associated with clinical recurrence following radical prostatectomy

Obesity is associated with worse outcomes in patients with ER-positive/HER2-negative disease

Walter and Eliza Hall Institute researcher awarded 2011 Gani Medal for Human Genetics

Medulloblastoma subtypes are separate diseases with different origins

ChipDX validates genetic signature for early-stage colon cancer

NanoString secures exclusive worldwide license to develop products for breast cancer intrinsic subtyping

Roche introduces X-tremeGENE 9, X-tremeGENE HP reagents

HDAC inhibitors may be used to fight against skin cancers

Exiqon announces launch of 6th generation of miRCURY LNA microRNA Arrays

Pivotal Phase II study data of romidepsin in relapsed PTCL presented at ASH 2010

Seven studies on Oncotype DX breast cancer test to be presented at 33rd CTRC-AACR SABCS

Clinical studies participated by three investigators to be presented at ASH Annual Meeting and Exposition

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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