Clinical Trial News and Research

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Drug intervention may prevent heart damage caused by chemotherapy

There could be an intervention on the horizon to help prevent heart damage caused by the common chemotherapy drug doxorubicin, new research suggests.

26 Jan 2021

Accelerating vaccine rollout may provide greatest reduction in COVID-19 mortality

A thought-provoking preprint research paper posted to the medRxiv server suggests that among several factors that could potentially contribute to the design of an optimal vaccine strategy aimed at the most significant possible reduction in COVID-19 mortality, timing is likely to be the most important factor.

26 Jan 2021

Herd immunity to SARS-CoV-2 may not be achievable with current vaccines

A recent preprint research paper posted on the medRxiv server asks the question: “Is “herd immunity” to COVID-19 a realistic outcome of any immunization program with the two main vaccines currently licensed in the UK?”

25 Jan 2021

Researchers show how to estimate long-term efficacy of COVID-19 vaccines

Researchers at the University of North Carolina and the Fred Hutchinson Cancer Research Center in Washington have developed a way to evaluate vaccines' long-term efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

24 Jan 2021

New maintenance treatment for AML shows strong benefit for patients

Patients with acute myeloid leukemia (AML), the most common form of acute leukemia in adults, that has gone into remission following initial chemotherapy remain in remission longer and have improved overall survival when they are given a pill form of the cancer drug azacitidine as a maintenance treatment, according to a randomized, international phase 3 clinical trial for which Weill Cornell Medicine and NewYork-Presbyterian are trial sites.

22 Jan 2021

Researchers develop comprehensive framework to classify small-cell lung cancer

Researchers from The University of Texas MD Anderson Cancer Center have developed the first comprehensive framework to classify small-cell lung cancer (SCLC) into four unique subtypes, based on gene expression, and have identified potential therapeutic targets for each type in a study published today in Cancer Cell.

22 Jan 2021

Dynamic, customized treatment approaches for gastroesophageal cancers may improve survival rates

A phase 2 clinical trial providing personalized treatments based on the genetic profile of metastatic tumors in gastroesophageal cancers has found that using customized treatment approaches, and adapting them over time as tumors become resistant, led to higher rates of survival compared to historical controls.

21 Jan 2021

New drug target valid for breast cancer as well as lymphoma

One more piece of the puzzle has fallen into place behind a new drug whose anti-cancer potential was developed at the University of Alberta and is set to begin human trials this year, thanks to newly published research.

21 Jan 2021

Investigational combo therapy shows promise in treating TP53 mutant MDS and AML patients

Myelodysplastic Syndromes (MDS) and acute myeloid leukemia (AML) are rare hematologic malignancies of the bone marrow.

21 Jan 2021

Multimodal pain regimen minimizes opioid exposure, relieves acute pain in trauma patients

A multimodal pain regimen (MMPR) designed to minimize opioid exposure and relieve acute pain associated with traumatic injury kept patient self-reported pain scores low while also reducing the daily and total amount of opioid drugs given to trauma patients.

21 Jan 2021

Designer DNA agent reduces myeloma stem cell abundance, lowers disease burden in mice

Many patients with multiple myeloma, a type of blood cancer, eventually develop resistance to one treatment after another. That's in part because cancer stem cells drive the disease -- cells that continually self-renew. If a therapy can't completely destroy these malignant stem cells, the cancer is likely to keep coming back.

20 Jan 2021

Analysis reveals rapid surge in methamphetamine overdose deaths in the United States

Methamphetamine overdose deaths surged in an eight-year period in the United States, according to a study published today in JAMA Psychiatry.

20 Jan 2021

Novel non-steroid topical cream can safely and effectively treat plaque psoriasis

Psoriasis is a chronic inflammatory skin disease characterized by erythematous (red) patches and plaques.

19 Jan 2021

Study predicts good passive immunotherapy donors to combat COVID-19

A US-based research team determine good candidates for convalescent plasma donations in promoting passive immunity among severely-ill COVID-19 patients.

19 Jan 2021

Magnetic nanoparticles guide neurite growth in dopaminergic cells

Magnetic nanoparticles raise hopes of treatments for Parkinson’s.

19 Jan 2021

Early administration of ivermectin could help reduce viral transmission in COVID-19 patients

A small pilot study suggests that early administration of ivermectin can reduce viral loads and symptom duration in patients with mild COVID-19, which in turn could help reduce viral transmission.

19 Jan 2021

Green Mediterranean diet reduces non-alcoholic fatty liver disease, show randomized trials

A green Mediterranean (MED) diet reduces intrahepatic fat more than other healthy diets and cuts non-alcoholic fatty liver disease (NAFLD) in half, according to a long-term clinical intervention trial led by Ben-Gurion University of the Negev researchers and a team of international colleagues.

18 Jan 2021

Clinical Trial News and Research

Drug intervention may prevent heart damage caused by chemotherapy

Accelerating vaccine rollout may provide greatest reduction in COVID-19 mortality

Herd immunity to SARS-CoV-2 may not be achievable with current vaccines

Researchers show how to estimate long-term efficacy of COVID-19 vaccines

New maintenance treatment for AML shows strong benefit for patients

Researchers develop comprehensive framework to classify small-cell lung cancer

Dynamic, customized treatment approaches for gastroesophageal cancers may improve survival rates

New drug target valid for breast cancer as well as lymphoma

Investigational combo therapy shows promise in treating TP53 mutant MDS and AML patients

Multimodal pain regimen minimizes opioid exposure, relieves acute pain in trauma patients

Designer DNA agent reduces myeloma stem cell abundance, lowers disease burden in mice

Analysis reveals rapid surge in methamphetamine overdose deaths in the United States

Novel non-steroid topical cream can safely and effectively treat plaque psoriasis

Study predicts good passive immunotherapy donors to combat COVID-19

Magnetic nanoparticles guide neurite growth in dopaminergic cells

Early administration of ivermectin could help reduce viral transmission in COVID-19 patients

Green Mediterranean diet reduces non-alcoholic fatty liver disease, show randomized trials

Study finds new evidence about the positive role of androgens in breast cancer treatment

Personalized neuromodulation approach provides relief from severe depression symptoms

Analysis supports phase 3 trials of Johnson & Johnson's COVID-19 vaccine

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