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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Study shows how mutant huntingtin protein triggers brain cell death

In 1993, scientists discovered that a single mutated gene, HTT, caused Huntington's disease, raising high hopes for a quick cure. Yet today, there's still no approved treatment.

7 Mar 2021

Children may transmit SARS-CoV-2 at same level as adults, suggests study

Researchers studied SARS-CoV-2 viral loads in over a thousand individuals, including both adults and children. They found the loads to be comparable, suggesting they may play an equal role in COVID-19 transmission.

5 Mar 2021

A SARS-CoV-2 spike protein adjuvant vaccine candidate produces durable rapid protection in vivo

A recent study reports the safety and high efficacy of an adjuvanted vaccine candidate against SARS-CoV-2 and the complications of COVID-19.

5 Mar 2021

Identification of neutralizing IFNL3 autoantibodies in severe COVID-19 cases

Scientists have recently developed a novel alternative molecular display technology called Molecular Indexing of Proteins by Self Assembly (MIPSA). Their research explains how this technology overcomes the critical disadvantages of PLATO and other full-length protein array technologies.

5 Mar 2021

Discovery offers a precise route to treat inflammation associated with neuropathic pain

One of the hallmarks of chronic pain is inflammation, and scientists at the UNC School of Medicine have discovered that anti-inflammatory cells called MRC1+ macrophages are dysfunctional in an animal model of neuropathic pain.

5 Mar 2021

A small sensor can be used for rapid detection of RNA and DNA

In less than a second, a small sensor used in brain chemistry research can detect the key molecules that provide the genetic instructions for life, RNA, and DNA, a new study from American University shows

5 Mar 2021

Proteomics analysis from aggressive human cancers can help identify potential therapeutic targets

Researchers at Baylor College of Medicine show that analysis of the proteomics, or all the protein data, from aggressive human cancers is a useful approach to identify potential novel therapeutic targets.

4 Mar 2021

Study explains how the B.1.1.7 SARS-CoV-2 variant is more transmissible

New research led by Thushan I. de Silva from the University of Sheffield proposes that increases in subgenomic RNA (sgRNA) expression cause increased viral transmissibility and subsequent infection. They suggest the ORF9 protein, found in high amounts of sgRNA, could be regulating interferon responses.

4 Mar 2021

SARS-CoV-2-derived mutant peptides hamper T cells' ability to recognize and destroy infected cells

A deep sequencing study of 747 SARS-CoV-2 virus isolates has revealed mutant peptides derived from the virus that cannot effectively bind to critical proteins on the surface of infected cells and, in turn, hamper activation of CD8+ killer T cells that recognize and destroy these infected cells.

4 Mar 2021

New mRNA treatment appears to stop replication of flu and Covid-19 viruses

With a relatively minor genetic change, a new treatment developed by researchers at the Georgia Institute of Technology and Emory University appears to stop replication of both flu viruses and the virus that causes Covid-19.

4 Mar 2021

Study reveals a small molecule inhibits SARS-CoV-2 infection in cells

Researchers found a small molecule that inhibits different virus proteins and significantly reduces infection in cells. Combined with the antiviral remdesivir, its potency increases significantly, suggesting it may be a potential antiviral candidate for the treatment of COVID-19.

4 Mar 2021

Delayed detection of oral fluid anti-SARS-CoV-2 antibodies increases the time to viral clearance

A prospective observational study has revealed that the late appearance of anti-SARS-CoV-2 antibodies in oral fluid, absence of fever as an early symptom, and elevated BMI are associated with delayed clearance of viral RNA in mild to moderate COVID-19 patients.

4 Mar 2021

Novel host-viral-microbiome interactions during COVID-19 may determine outcome

A new preprint on the medRxiv* server discusses how the underlying disease mechanisms are regulated such that the local or mucosal immune response is distinct from the systemic response.

4 Mar 2021

Study reports persistent SARS-CoV-2 with increasing viral variants in pediatric patients

New research, published on medRxiv preprint server, has reported the effect of prolonged SARS-CoV-2 infection in immunocompromised children and young adults.

4 Mar 2021

Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis

Scientists at the Francis Crick Institute and UCL have identified the trigger of a key cellular change in amyotrophic lateral sclerosis (ALS), a type of motor neurons disease.

4 Mar 2021

Liquid-handling robots for wastewater surveillance help predict COVID-19 cases in San Diego

In earlier days of the COVID-19 pandemic, before diagnostic testing was widely available, it was difficult for public health officials to keep track of the infection's spread, or predict where outbreaks were likely to occur.

3 Mar 2021

Genomic surveillance can help identify how SARS-CoV-2 spreads in care homes

Care homes are at high risk of experiencing outbreaks of COVID-19, the disease caused by SARS-CoV-2. Older people and those affected by heart disease, respiratory disease and type 2 diabetes - all of which increase with age - are at greatest risk of severe disease and even death, making the care home population especially vulnerable.

3 Mar 2021

New transcriptome‐based aging clock reads the biological age of an organism

Using the model organism Caenorhabditis elegans, researchers at the University of Cologne have developed an 'aging clock' that reads the biological age of an organism directly from its gene expression, the transcriptome.

3 Mar 2021

Pharmacists discover active substances that block SARS-CoV-2 replication

A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease.

3 Mar 2021

UTHSC researchers awarded $1.9 million to study white matter mechanisms underlying dementia

The National Institute of Neurological Disorders and Stroke has awarded two UTHSC researchers over $1.9 million to study the pathogenesis of white matter damage, a main contributing factor to dementia.

3 Mar 2021

RNA News and Research

Further Reading

Study shows how mutant huntingtin protein triggers brain cell death

Children may transmit SARS-CoV-2 at same level as adults, suggests study

A SARS-CoV-2 spike protein adjuvant vaccine candidate produces durable rapid protection in vivo

Identification of neutralizing IFNL3 autoantibodies in severe COVID-19 cases

Discovery offers a precise route to treat inflammation associated with neuropathic pain

A small sensor can be used for rapid detection of RNA and DNA

Proteomics analysis from aggressive human cancers can help identify potential therapeutic targets

Study explains how the B.1.1.7 SARS-CoV-2 variant is more transmissible

SARS-CoV-2-derived mutant peptides hamper T cells' ability to recognize and destroy infected cells

New mRNA treatment appears to stop replication of flu and Covid-19 viruses

Study reveals a small molecule inhibits SARS-CoV-2 infection in cells

Delayed detection of oral fluid anti-SARS-CoV-2 antibodies increases the time to viral clearance

Novel host-viral-microbiome interactions during COVID-19 may determine outcome

Study reports persistent SARS-CoV-2 with increasing viral variants in pediatric patients

Researchers identify the trigger of key cellular change in amyotrophic lateral sclerosis

Liquid-handling robots for wastewater surveillance help predict COVID-19 cases in San Diego

Genomic surveillance can help identify how SARS-CoV-2 spreads in care homes

New transcriptome‐based aging clock reads the biological age of an organism

Pharmacists discover active substances that block SARS-CoV-2 replication

UTHSC researchers awarded $1.9 million to study white matter mechanisms underlying dementia

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