Clinical Trial News and Research

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Glycyrrhizin in licorice root neutralizes SARS-CoV-2 in vitro by inhibiting the main protease Mpro

In a recent bioRxiv* preprint paper, researchers from Germany analyzed aqueous licorice root extract for its neutralizing activity against SARS-CoV-2 in vitro. They identified glycyrrhizin, the primary active ingredient in the root, and revealed the underlying mechanism of viral neutralization.

5 Jan 2021

UC-MSC infusions reduce risk of death, quicken recovery time in severe COVID-19 cases

Dr. Camilo Ricordi, director of the Diabetes Research Institute and Cell Transplant Center at the University of Miami Miller School of Medicine, and his team of international collaborators are reporting the results of a groundbreaking randomized controlled trial showing umbilical cord-derived mesenchymal stem cell (UC-MSC) infusions safely reduce risk of death and quicken time to recovery for the most severe COVID-19 patients.

5 Jan 2021

Mid-term clinical trial results of two cell therapies for critical limb ischemia show similar outcomes

Mid-term results of the first clinical trial designed specifically to evaluate the safety and effectiveness of two cell therapies that are showing early promise in treating angiitis-induced critical limb ischemia were released today in STEM CELLS Translational Medicine.

5 Jan 2021

Cellid, IVI sign research service contract to evaluate immunogenicity of COVID-19 vaccine

Cellid and the International Vaccine Institute have exchanged a collaborative research agreement to analyze the immunogenicity of the COVID-19 vaccine "AdCLD-CoV19".

5 Jan 2021

Groundbreaking research project shows how brain health can traverse generations

Your father's exercise routine may have made you smarter according to EU-funded researchers studying how lifestyle choices affect brain function and memory. The findings could lead to new treatments for neurodegenerative conditions such as Alzheimer's disease.

5 Jan 2021

Many health plans now must cover full cost of expensive HIV prevention drugs

Ted Howard started taking Truvada a few years ago because he wanted to protect himself against HIV, the virus that causes AIDS. But the daily pill was so pricey he was seriously thinking about giving it up.

5 Jan 2021

Genetic risk score can be used to determine risk of developing prostate cancer

Some racial and ethnic groups suffer relatively more often, and fare worse, from common ailments compared to others. Prostate cancer is one disease where such health disparities occur: risk for the disease is about 75 percent higher, and prostate cancer is more than twice as deadly, in Blacks compared to whites.

4 Jan 2021

Machine-learning method can crunch data to find new uses for existing drugs

Scientists have developed a machine-learning method that crunches massive amounts of data to help determine which existing medications could improve outcomes in diseases for which they are not prescribed.

4 Jan 2021

Higher hemoglobin threshold does not improve outcomes in preterm infants

Very low birthweight infants are at a high risk for anemia and often need blood transfusions to survive. Some doctors use a higher level and some use a lower level of red blood cells to order a transfusion.

4 Jan 2021

Phase 3 results show investigational vaccine is effective in preventing severe COVID-19

The investigational vaccine known as mRNA-1273 was 94.1% efficacious in preventing symptomatic coronavirus disease 2019 (COVID-19), according to preliminary results from a Phase 3 clinical trial reported in the New England Journal of Medicine.

3 Jan 2021

WHO lists Comirnaty COVID-19 mRNA vaccine for emergency use

The World Health Organization (WHO) today listed the Comirnaty COVID-19 mRNA vaccine for emergency use, making the Pfizer/BioNTech vaccine the first to receive emergency validation from WHO since the outbreak began a year ago.

3 Jan 2021

Researchers discover how chromosomal instability allows cancer cells to avoid immune defenses

Cancer cells are known for spreading genetic chaos. As cancer cells divide, DNA segments and even whole chromosomes can be duplicated, mutated, or lost altogether. This is called chromosomal instability, and scientists at Memorial Sloan Kettering have learned that it is associated with cancer's aggressiveness.

28 Dec 2020

Phase 3 trial of Novavax COVID-19 vaccine candidate begins enrolling volunteers

The Phase 3 trial of another investigational coronavirus disease 2019 (COVID-19) vaccine has begun enrolling adult volunteers.

28 Dec 2020

FDA authorizes first device to treat patients with walled-off pancreatic necrosis

Today, the U.S. Food and Drug Administration authorized marketing of the EndoRotor System to resect (cut out) and remove necrotic (dead) tissue for patients with walled-off pancreatic necrosis (WOPN), a potentially deadly condition which can occur several weeks after an episode of severe acute pancreatitis, often requiring tissue removal.

23 Dec 2020

Health disparities in cancer and COVID-19 are caused by similar factors

Income level, employment, housing location, medical insurance, education, tobacco and alcohol use, diet and obesity, access to medical care. These are some of the factors causing worse cancer outcomes in people who are Black.

23 Dec 2020

E-cigarettes, as consumer products, are not associated with smoking cessation

E-cigarette use has risen steeply and mostly without regulation over the past decade. The devices have diversified into a dizzying array of vape pens, tank systems, "mods," and more, mass-marketed and sold to the public.

23 Dec 2020

COVID vaccines appear safe and effective, but key questions remain

The recent rollout of two newly authorized COVID-19 vaccines is a bright ray of hope at the pandemic's darkest hour.

23 Dec 2020

Researchers test effects of full doses of anticoagulants in COVID-19 patients

Three clinical trial platforms working together to test the effects of full doses of anticoagulants (blood thinners) in COVID-19 patients have paused enrollment for one group of patients.

23 Dec 2020

First human clinical trial validates the practicality, accuracy of oxygen-sensing liquid bandage

In the first human clinical trial, researchers at Massachusetts General Hospital and surgeons at Beth Israel Deaconess Medical Center have validated the practicality and accuracy of an oxygen-sensing liquid bandage that measures the concentration of oxygen in transplanted tissue

22 Dec 2020

Community-based programs reduce gender-based violence among teenage boys

Through small, neighborhood classes, researchers at UPMC Children's Hospital of Pittsburgh and Promundo-US significantly reduced sexual violence among teenage boys living in areas of concentrated disadvantage.

22 Dec 2020

Clinical Trial News and Research

Glycyrrhizin in licorice root neutralizes SARS-CoV-2 in vitro by inhibiting the main protease Mpro

UC-MSC infusions reduce risk of death, quicken recovery time in severe COVID-19 cases

Mid-term clinical trial results of two cell therapies for critical limb ischemia show similar outcomes

Cellid, IVI sign research service contract to evaluate immunogenicity of COVID-19 vaccine

Groundbreaking research project shows how brain health can traverse generations

Many health plans now must cover full cost of expensive HIV prevention drugs

Genetic risk score can be used to determine risk of developing prostate cancer

Machine-learning method can crunch data to find new uses for existing drugs

Higher hemoglobin threshold does not improve outcomes in preterm infants

Phase 3 results show investigational vaccine is effective in preventing severe COVID-19

WHO lists Comirnaty COVID-19 mRNA vaccine for emergency use

Researchers discover how chromosomal instability allows cancer cells to avoid immune defenses

Phase 3 trial of Novavax COVID-19 vaccine candidate begins enrolling volunteers

FDA authorizes first device to treat patients with walled-off pancreatic necrosis

Health disparities in cancer and COVID-19 are caused by similar factors

E-cigarettes, as consumer products, are not associated with smoking cessation

COVID vaccines appear safe and effective, but key questions remain

Researchers test effects of full doses of anticoagulants in COVID-19 patients

First human clinical trial validates the practicality, accuracy of oxygen-sensing liquid bandage

Community-based programs reduce gender-based violence among teenage boys

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