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Study offers a new, effective therapeutic option against glioblastoma

A study recently accepted for publication in The Journal of Clinical Investigation describes a new and effective therapy to treat glioblastoma: the concomitant use of ADI-PEG20 together with focal brain radiotherapy.

22 Feb 2022

Mechanisms of IL-6 expression in peripheral monocyte-derived macrophages infected with SARS-CoV-2

Researchers examined the detailed mechanisms of ‘cytokine storm’ that induces ARDS, often resulting in the death of severely ill COVID-19 patients.

21 Feb 2022

Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

Codiak BioSciences, Inc., a clinical-stage biopharmaceutical company pioneering the development of exosome-based therapeutics as a new class of medicines, today announced the online publication of a new manuscript, Exosome mediated genetic reprogramming of tumor associated macrophages by exoASO-STAT6 leads to potent monotherapy anti-tumor efficacy, in the American Association for the Advancement of Science's journal, Science Advances.

18 Feb 2022

Study identifies a protein complex critical for regulating apoptosis and necroptosis

Cell death plays an important role in normal human development and health but requires tightly orchestrated balance to avert disease. Too much can trigger a massive inflammatory immune response that damages tissues and organs. Not enough can interfere with the body's ability to fight infection or lead to cancer.

18 Feb 2022

Response of peripheral immune cells to ex vivo SARS-CoV-2 exposure compared to SARS-CoV

Researchers characterized the responses of the PBMCs at the individual cell and cell type levels against SARS-CoV-2 and SARS-CoV ex vivo.

18 Feb 2022

Changes in the brain cortex of COVID-19 patients associated with inflammatory biomarkers

Recently, a team of researchers examined the neurotoxic damage to the brain’s cortical region in patients hospitalized due to COVID-19.

18 Feb 2022

Research shows alterations in transfer RNAs at the epigenetic level in cancer

A recently published paper in the journal Molecular Cancer by the group of Dr. Manel Esteller, Director of the Josep Carreras Leukaemia Research Institute, ICREA Research Professor and Genetics Chairman at the University of Barcelona, shows that transfer RNAs for certain amino acids are altered at the epigenetic level in some types of cancer, expressing it in an exaggerated manner in some cases and being deficient in others.

17 Feb 2022

New METPlatform allows researchers to test drugs for possible use in brain metastases

It is estimated that about a quarter of cancer patients are at risk of brain metastases, a rate that is increasing especially among those who suffer relapses after having undergone different cancer treatments.

17 Feb 2022

Locoregional treatment does not improve outcomes in women with stage IV breast cancer

Treating a tumor in the breast when distant metastases have already occurred does not improve outcomes in women with stage IV breast cancer, according to a new study published in the Journal of Clinical Oncology.

17 Feb 2022

Optical genome mapping holds potential to become an important component of leukemia diagnostics

Optical genome mapping involves the extraction of very long DNA molecules, for example routinely collected blood samples or bone marrow material from patients.

17 Feb 2022

Combating leukemia cells by disrupting their energy maintenance mechanism

Acute myeloid leukemia, which affects blood and bone marrow cells, is a particularly dangerous form of cancer. More than half of patients under the age of 60 die.

17 Feb 2022

Illumina partners with centers across France to advance a precision medicine approach for patients with late-stage cancer

Joint study will assess clinical value of comprehensive genomic profiling (CGP) on cancer therapy options in patients with advanced disease

From Illumina, Inc. 17 Feb 2022

Frequency and function of SARS-CoV-2-specific T cells in individuals with pulmonary PASC

Researchers examined patients with pulmonary PASC of SARS-CoV-2 to determine the frequency and function of SARS-CoV-2-specific T cells in their blood.

17 Feb 2022

Study shows how some cancer cells immobilize T cells

Our immune systems have the potential to find and destroy cancer cells. But cancer cells can be clever and develop tricks to evade the immune system.

16 Feb 2022

UVMCC researchers address new paradigms in rectal cancer multidisciplinary care

In recent years total neoadjuvant treatment (TNT) - a potent new treatment approach for advanced colorectal cancer that confronts tumors with aggressive rounds of chemotherapy and chemoradiation followed by surgery to remove the cancerous tissue - has emerged as the standard of care.

16 Feb 2022

Developing nanoplatforms for direct drug delivery to T cells

T cells, also known as lymphocytes, have important roles in various immune reactions. However, there are only a few reports on delivery systems into T cells. Realizing this, it is essential to work and actively contribute in controlling immune systems.

16 Feb 2022

Study suggests tea polyphenols may modulate COVID-19 via intestinal microbiota

A new study discusses the state of current knowledge about the potential use of tea polyphenols in the prevention and treatment of COVID-19.

16 Feb 2022

Features of platelet-immune crosstalk in healthy recipients of two doses of mRNA-based SARS-CoV-2 vaccine BNT162b2

Researchers investigated the role of platelets in the adverse immune response against a COVID-19 vaccine.

16 Feb 2022

The long-term consequences of SARS-CoV-2 infection in people with HIV

In a recent study posted to the medRxiv* preprint server, an interdisciplinary team of researchers from the United States (US) analyzed a cohort of patients with human immunodeficiency virus (HIV) (PWH) recovering from coronavirus disease 2019 (COVID-19) and characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immune responses in these patients.

15 Feb 2022

Use of immunosuppressants for inflammatory rheumatic diseases and the associated risk of severe COVID-19

A recent study posted to the medRxiv* preprint server investigated the risk of severe/fatal coronavirus disease 2019 (COVID-19) in patients treated with immunosuppressants for inflammatory rheumatic diseases (IRD).

15 Feb 2022

Tumor News and Research

Study offers a new, effective therapeutic option against glioblastoma

Mechanisms of IL-6 expression in peripheral monocyte-derived macrophages infected with SARS-CoV-2

Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

Study identifies a protein complex critical for regulating apoptosis and necroptosis

Response of peripheral immune cells to ex vivo SARS-CoV-2 exposure compared to SARS-CoV

Changes in the brain cortex of COVID-19 patients associated with inflammatory biomarkers

Research shows alterations in transfer RNAs at the epigenetic level in cancer

New METPlatform allows researchers to test drugs for possible use in brain metastases

Locoregional treatment does not improve outcomes in women with stage IV breast cancer

Optical genome mapping holds potential to become an important component of leukemia diagnostics

Combating leukemia cells by disrupting their energy maintenance mechanism

Illumina partners with centers across France to advance a precision medicine approach for patients with late-stage cancer

Frequency and function of SARS-CoV-2-specific T cells in individuals with pulmonary PASC

Study shows how some cancer cells immobilize T cells

UVMCC researchers address new paradigms in rectal cancer multidisciplinary care

Developing nanoplatforms for direct drug delivery to T cells

Study suggests tea polyphenols may modulate COVID-19 via intestinal microbiota

Features of platelet-immune crosstalk in healthy recipients of two doses of mRNA-based SARS-CoV-2 vaccine BNT162b2

The long-term consequences of SARS-CoV-2 infection in people with HIV

Use of immunosuppressants for inflammatory rheumatic diseases and the associated risk of severe COVID-19

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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