Gastrointestinal Tract News and Research

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Researchers reveal mechanisms that help C. difficile pathogen to survive in low oxygen levels

Researchers from ITQB NOVA, in collaboration with the Institut Pasteur in Paris, have shed light on the mechanisms that allow Clostridioides difficile, a pathogen that can only grow in oxygen-free environments, to be able to survive low oxygen levels.

3 Nov 2020

SARS-CoV-2 virus may target red marrow and prevent the formation of new erythrocytes

Specialists from the Department of Fundamental Medicine of Far Eastern Federal University (FEFU) with Russian and Japanese colleagues have probed into mechanisms of COVID-19 inside-the-body distribution linked to erythrocytes damaging.

30 Oct 2020

Beetroot peptide may be a good candidate for development of a drug to treat inflammatory diseases

In a recent study, a research group led by Christian Gruber at MedUni Vienna's Institute of Pharmacology isolated a peptide (small protein molecule) from beetroot.

30 Oct 2020

Study suggests a role for the hypothalamus in genetic susceptibility to IBD

Using sophisticated 3D genomic mapping and integrating with public data resulting from genome-wide association studies, researchers at Children's Hospital of Philadelphia have found significant genetic correlations between inflammatory bowel disease and stress and depression.

29 Oct 2020

Researchers use genomic tools and supercomputers to study the infant gut microbiome

Since 2017, University of Alabama at Birmingham researchers Casey Morrow, Ph.D., and Hyunmin Koo, Ph.D., have used powerful genomic tools and supercomputers that analyze massive amounts of genetic data to identify individual strains within single species of the gut microbiome.

29 Oct 2020

Mouth may be primary route of SARS-CoV-2 infection and transmission

A new study published on the preprint server medRxiv in October 2020 shows that the virus also multiplies robustly in the oral cavity, indicating that saliva plays a role in viral transmission.

29 Oct 2020

Gut's immune response to SARS-CoV-2 very different from the lung

Megan L. Stanifer et al. study the immune response in the human gut upon SARS-CoV-2 infection. The study published as a bioRxiv* preprint reveals a robust proinflammatory response: a cell type-specific or a tissue-specific regulation of interferon-mediated signaling during SARS-CoV-2 infection.

27 Oct 2020

Scientists uncover surprising players in acute liver failure

Acute liver failure is a devastating, rapidly progressing disease that results in death in 80% of cases, unless an emergency liver transplant is performed. In the developed world, its leading cause is a substantial overdose of acetaminophen, also known as paracetamol.

27 Oct 2020

Scientists use new approach to chart the spread of drug-resistant hospital bacteria

Scientists have used genome sequencing to reveal the extent to which a drug-resistant gastrointestinal bacterium can spread within a hospital, highlighting the challenge hospitals face in controlling infections.

27 Oct 2020

Research shows wrinkled 'super pea' may reduce risk of type 2 diabetes

A type of wrinkled 'super pea' may help control blood sugar levels and could reduce the risk of type 2 diabetes, suggests a new study.

27 Oct 2020

Researchers receive $11 million grant to study factors involved in multi-drug resistant infections

A study aimed at better understanding why some critically ill patients develop multidrug-resistant infections is underway by researchers at The University of Texas Health Science Center at Houston.

14 Oct 2020

Study determines mechanisms underlying abnormal development of nervous system in Hirschsprung disease

Ankush Gosain, MD, PhD, of Le Bonheur Children's Hospital and the University of Tennessee Health Science Center has focused his research on determining the mechanisms underlying abnormal development of the enteric nervous system in Hirschsprung disease.

14 Oct 2020

New biomarker may help identify patients at risk for graft-versus-host disease after stem cell transplants

A recent report published in Science Translational Medicine by MUSC Hollings Cancer Center investigator Sophie Paczesny, M.D., Ph.D., sheds light on immune cell biomarkers that may reveal which patients are most at risk for graft-versus-host disease (GVHD), a life-threatening condition that can arise after hematopoietic stem cell transplantation (HSCT) for treatment of liquid cancers such as leukemia.

7 Oct 2020

PATH wins grant to develop oral treatment option for soil-transmitted helminth infections

PATH announced today they received a grant from Japan's Global Health Innovative Technology Fund to develop a new oral treatment option for soil-transmitted helminth infections.

1 Oct 2020

Cincinnati Children's research leads to approval of new drug for hypereosinophilic syndrome

Following two decades of research on a group of rare diseases called hypereosinophilic syndrome at Cincinnati Children's Hospital Medical Center, the U.S. Food and Drug Administration has approved the drug Nucala (mepolizumab) for use in the treatment of patients with hypereosinophilic syndrome.

28 Sep 2020

Polyphenolic compound offers new therapeutic option for chronic inflammatory disorders

Various plants and their products are known to contain "bioactive" ingredients that can alleviate human diseases. These "phytocompounds" often contain restorative biological properties such as anti-cancerous, antioxidant, and anti-inflammatory effects.

24 Sep 2020

Study: 5 to 10% of surgically induced weight loss linked with cardiovascular benefits

A Cleveland Clinic study shows that 5 to 10 percent of surgically induced weight loss is associated with improved life expectancy and cardiovascular health.

23 Sep 2020

Spider venom peptide could help stop pain in irritable bowel syndrome

Their study titled, "A spider-venom peptide with multi-target activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome," is published in the latest issue of the journal Pain.

22 Sep 2020

Researchers discover a hormone that might help tackle malabsorption

Scientists at Cincinnati Children's used human intestinal organoids grown from stem cells to discover how our bodies control the absorption of nutrients from the food we eat.

22 Sep 2020

Sotorasib phase 1 trial shows encouraging anti-cancer activity in lung, colorectal cancers

A phase 1 clinical trial of sotorasib (AMG 510) in patients with heavily pretreated advanced solid tumors shows encouraging anti-cancer activity, especially in lung and colorectal cancers, reports a new study led by City of Hope and other renowned comprehensive cancer centers.

22 Sep 2020

Gastrointestinal Tract News and Research

Researchers reveal mechanisms that help C. difficile pathogen to survive in low oxygen levels

SARS-CoV-2 virus may target red marrow and prevent the formation of new erythrocytes

Beetroot peptide may be a good candidate for development of a drug to treat inflammatory diseases

Study suggests a role for the hypothalamus in genetic susceptibility to IBD

Researchers use genomic tools and supercomputers to study the infant gut microbiome

Mouth may be primary route of SARS-CoV-2 infection and transmission

Gut's immune response to SARS-CoV-2 very different from the lung

Scientists uncover surprising players in acute liver failure

Scientists use new approach to chart the spread of drug-resistant hospital bacteria

Research shows wrinkled 'super pea' may reduce risk of type 2 diabetes

Researchers receive $11 million grant to study factors involved in multi-drug resistant infections

Study determines mechanisms underlying abnormal development of nervous system in Hirschsprung disease

New biomarker may help identify patients at risk for graft-versus-host disease after stem cell transplants

PATH wins grant to develop oral treatment option for soil-transmitted helminth infections

Cincinnati Children's research leads to approval of new drug for hypereosinophilic syndrome

Polyphenolic compound offers new therapeutic option for chronic inflammatory disorders

Study: 5 to 10% of surgically induced weight loss linked with cardiovascular benefits

Spider venom peptide could help stop pain in irritable bowel syndrome

Researchers discover a hormone that might help tackle malabsorption

Sotorasib phase 1 trial shows encouraging anti-cancer activity in lung, colorectal cancers

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