Mouse Model News and Research

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New therapeutic cocktails show promise for long-lasting asthma relief

Current asthma treatments don't work in all patients, and they don't provide long-term relief from potentially deadly asthma attacks.

19 Feb 2025

Vitamin E supplementation may reduce food allergy development in newborns

New research found that supplementing maternal diet with α-tocopherol, a form of vitamin E, can reduce the development of food allergy and anaphylaxis in newborn mice.

19 Feb 2025

Common antidepressant Fluoxetine protects from sepsis-induced death

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19 Feb 2025

New study reveals LRP1's crucial role in bone formation and joint development

Skeletal conditions such as developmental dysplasia of the hip (DDH), osteoporosis, and osteoarthritis affect millions worldwide, often causing chronic pain and disability. These disorders stem from complex genetic and environmental interactions that disrupt bone formation and joint development.

19 Feb 2025

Cholesterol metabolite linked to Parkinson's disease development in mice

Researchers led by Zhentao Zhang at Wuhan University, China have discovered a cholesterol metabolite that plays a critical role in the development of Parkinson's disease in mice.

18 Feb 2025

Researchers develop mouse model to study neutrophilic asthma

A better understanding of inflammation and lung immunity over the past two decades has led to new, innovative treatments for asthma, including biologic therapies.

18 Feb 2025

Senolytic agent ABT-263 mitigates GI cancer risk after radiation exposure

A new research paper was published by Aging (Aging-US) on January 8, 2025, in Volume 17, Issue 1, titled "Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc1638N/+ mice."

18 Feb 2025

Gene therapy breakthrough offers hope for severe Dravet syndrome cases

AAV-Navβ1 gene therapy effectively reduces seizures and prolongs life in a mouse model of SCN1B-linked Dravet syndrome, paving the way for future treatments.

18 Feb 2025

Scientists pinpoint metabolic failure as the cause of muscle loss in aging

A multi-omics study reveals that impaired branched-chain amino acid (BCAA) catabolism is a key driver of sarcopenia, suggesting it as a potential therapeutic target.

17 Feb 2025

Study reveals key role of opsin 3 in regulating food intake and energy balance

Scientists discovered years ago that the hypothalamus - which helps to manage body temperature, hunger, sex drive, sleep and more - includes neurons that express the protein opsin 3 (OPN3).

14 Feb 2025

Study uncovers how MAGE-4 and Pten loss promote aggressive tumor growth

A study published in Science Advances reveals a novel strategy that allows tumors to evade the body's immune response critical for their elimination.

12 Feb 2025

New insights could help prevent peripheral neuropathy or slow disease onset

An increase in high-fat, high-fructose foods in people's diets has contributed to a dramatic increase in type 2 diabetes.

12 Feb 2025

Diabetes plays key role in the emergence and expansion of antibiotic resistance

Antibiotics are powerful, fast-acting medications designed to eradicate bacterial infections. However, in recent years, their dependability has waned as antibiotic resistant bacteria continues to evolve and spread.

12 Feb 2025

Gut microbiota key to predicting sensitivity to common food additives

Widely used by the food industry, emulsifiers – a type of food additive – are found in many daily foods (sliced bread, ice creams, crème fraîche, plant milks, etc.).

11 Feb 2025

UCLA study reveals key role of mismatch repair genes in Huntington’s disease

A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and triggering downstream pathologies and motor impairment, shedding light on disease mechanisms and potential new ways to develop therapies.

11 Feb 2025

Gut microbes influence how well cancer patients respond to immunotherapy

Researchers discovered that gut microbiota-derived hexa-acylated LPS enhances the effectiveness of anti-PD-1 cancer immunotherapy, while penta-acylated LPS may suppress immune responses.

11 Feb 2025

PDZK1's role in estrogen-induced cholestasis unveiled

Announcing a new publication for Acta Materia Medica journal. Estrogens have been reported to cause dysfunction in biliary transport systems, thereby inducing cholestasis. Multidrug resistance-associated protein 2 (MRP2) is a transporter responsible for independent bile flow.

11 Feb 2025