Tissue Engineering News and Research

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Dramatic advances in the fields of biochemistry, cell and molecular biology, genetics, biomedical engineering and materials science have given rise to the remarkable new cross-disciplinary field of tissue engineering. Tissue engineering uses synthetic or naturally derived, engineered biomaterials to replace damaged or defective tissues, such as bone, skin, and even organs.

Study uncovers mechanism underlying nerve cell organization in the spinal cord of developing embryo

Scientists have uncovered how nerve cells in the spinal cord are organized in precise patterns during embryo development - a finding that could give insight into regenerative medicine.

29 Jun 2017

New technique reveals extracellular matrix structure of organs and tumors

A world of details revealed?Cells which are organized together to form tissues rely on the extracellular matrix as a foundation for attachment, to arrange themselves properly and to sense how to behave when their environment changes.

28 Jun 2017

DNA methylation can provide effective markers for major cancers, study reveals

In a new study, published online in the July 26 issue of PNAS, researchers at University of California San Diego School of Medicine, with colleagues in Xijing Hospital and Sun Yat-sen Cancer Center in China, report that DNA methylation can provide effective markers for at least four major cancers, not only correctly differentiating malignant tissues from normal, but also providing information on prognosis and survival.

28 Jun 2017

MSU researcher developing new miniature models to study heart disease and sickle cell anemia

A Mississippi State University researcher is developing new miniature models to better understand the factors that lead to heart disease and sickle cell anemia.

24 Jun 2017

Removal of senescent cells could delay onset of age-related pathologies

A recent study, led by an international team of researchers confirms that targeted removal of senescent cells (SnCs), accumulated in many vertebrate tissues as we age, contribute significantly in delaying the onset of age-related pathologies.

9 Jun 2017

Researchers receive federal funding to study consequences of West Nile and Zika virus infections

A Georgia State University researcher, in collaboration with researchers at the University of Pennsylvania and Florida State University, has received a five-year, $7.7 million federal grant to study the consequences of West Nile and Zika virus infections on the human central nervous system.

2 Jun 2017

Chemical stimuli by small molecule can improve production of cartilage cells

Cell-based therapies could offer a way to treat cartilage injuries before the ultimate damage of osteoarthritis on articular cartilage.

11 May 2017

UAB symposium highlights use of tissue engineering to repair broken hearts

The third annual Cardiovascular Tissue Engineering Symposium met at the University of Alabama at Birmingham last month, a gathering of noted physicians and scientists who share the goal of creating new tissues and new knowledge that can prevent or repair heart disease and heart attacks.

9 May 2017

Researchers develop new model to analyze mechanical properties of tissue engineered cartilage

Researchers have developed a new model to analyze tissue engineered cartilage that allows for the use of a single method to assess functional tissue mechanics in cartilage constructs at all stages of development from the laboratory through large animal testing.

4 May 2017

Hair-derived keratin biomaterials show promise to regenerate skeletal muscle tissue and function

The use of human hair-derived keratin biomaterials to regenerate skeletal muscle has shown promise in new research that documents significant increases in both new muscle tissue formation and muscle function among mouse models of volumetric muscle loss.

27 Apr 2017

Removing senescent cells from joints could reverse progression of osteoarthritis

In a preclinical study in mice and human cells, researchers report that selectively removing old or 'senescent' cells from joints could stop and even reverse the progression of osteoarthritis.

26 Apr 2017

Scientists aim to combat antibiotic-resistant infections by harnessing synthetic mucus

Researchers are pursuing an innovative and unexpected new avenue in the quest to fight antibiotic resistance: synthetic mucus. By studying and replicating mucus' natural ability to control pathogenic bacteria, the scientists hope to find new methods for combating infections.

26 Apr 2017

Researchers use gene-editing tool to restore visual function in mouse models of retinitis pigmentosa

Using the gene-editing tool CRISPR/Cas9, researchers at University of California San Diego School of Medicine and Shiley Eye Institute at UC San Diego Health, with colleagues in China, have reprogrammed mutated rod photoreceptors to become functioning cone photoreceptors, reversing cellular degeneration and restoring visual function in two mouse models of retinitis pigmentosa.

21 Apr 2017

Study establishes potential of BAT receptors as druggable targets for treatment of obesity, diabetes

According to research published online in The FASEB Journal, scientists have discovered a way to increase the amount of metabolism-boosting brown adipose tissue (BAT) ("good" fat) by employing two receptors on BAT cells as potential therapeutic targets.

17 Apr 2017

Researchers develop biomaterials from apple waste for regeneration of bone, cartilage tissues

Researchers from UPM and CSIC have employed waste from the agri-food industry to develop biomaterials that are able to act as matrices to regenerate bone and cartilage tissues, which is of great interest for the treatment of diseases related to aging.

30 Mar 2017

Researchers create tiny bioengineered blood vessel grafts for surgical repair of damaged tissues

Scientists have been working diligently to create engineered tissue implants to repair or replace damaged or diseased tissue and organs; but their success hinges on the ability to build a sturdy connection linking the implant's blood vessels and the patient's existing vasculature.

28 Mar 2017

WPI researchers grow beating human heart cells on spinach leaves

Researchers face a fundamental challenge as they seek to scale up human tissue regeneration from small lab samples to full-size tissues, bones, even whole organs to implant in people to treat disease or traumatic injuries: how to establish a vascular system that delivers blood deep into the developing tissue.

23 Mar 2017

Study shows safety of Schwann cell transplantation for treating subacute thoracic spinal cord injury

A Phase I clinical trial that targeted individuals with new onset paraplegia to evaluate the safety of transplanting their own potentially neuroprotective Schwann cells into a trauma-induced spinal cord lesion showed no evidence of adverse effects after 1 year.

22 Mar 2017

Scientists use parsley and other plants to create human stem cell scaffolds

Borrowing from nature is an age-old theme in science. Form and function go hand-in-hand in the natural world and the structures created by plants and animals are only rarely improved on by humans.

21 Mar 2017

Researchers develop new platform for culturing pluripotent stem cells

A team of researchers in Japan has developed a new platform for culturing human pluripotent stem cells that provides far more control of culture conditions than previous tools by using micro and nanotechnologies.

14 Mar 2017