Yeast News and Research

RSS

Picomolar inhibitors to SARS-CoV-2 proteins

Now, a new study published on the preprint server bioRxiv in August 2020 reports the development of mini-inhibitors based on computational design, that are suitable for such topical use.

4 Aug 2020

Study shows how amyloid fibrils in Alzheimer's dissociate with infrared laser irradiation

The agglomeration of proteins into structures called amyloid plaques is a common feature of many neurodegenerative diseases, including Alzheimer's.

4 Aug 2020

SARS-CoV-2 lured away and trapped by a new decoy version of ACE2

Researchers in the United States and Canada have engineered affinity-optimized “receptor traps” that prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from binding to and infecting cells.

3 Aug 2020

Study finds synthetic neutralizing/enhancing antibodies to SARS-CoV-2

A new study published on the preprint server bioRxiv in July 2020 reports the discovery of some antibody molecules that have powerful enhancing or neutralizing activity against the virus, in a library of synthetic antibodies. These hold the promise of being useful for the prevention or treatment of this illness.

30 Jul 2020

'Synthetic lethality' could be exploited for cancer therapy

A Ludwig Cancer Research study has identified a new instance in which the simultaneous mutation of two nonessential genes--neither of which is on its own vital to cell survival--can cause cancer cell death.

28 Jul 2020

Simultaneous mutation of two nonessential genes can cause cancer cell death

A Ludwig Cancer Research study has identified a new instance in which the simultaneous mutation of two nonessential genes - neither of which is on its own vital to cell survival - can cause cancer cell death.

28 Jul 2020

Exploiting 'synthetic lethality' to identify cancer targets

With advances in genome sequencing, cancer treatments have increasingly sought to leverage the idea of "synthetic lethality," exploiting cancer-specific genetic defects to identify targets that are uniquely essential to the survival of cancer cells.

28 Jul 2020

Leftover fermented barley may reduce animals’ stress, improve pork quality

Tastier pork comes from pigs that eat the barley left over after making the Japanese liquor shochu. A team of professional brewers and academic farmers state that nutrients in the leftover fermented barley may reduce the animals' stress, resulting in better tasting sirloin and fillets.

21 Jul 2020

Researchers unravel key mechanisms behind the mysteries of aging

Molecular biologists and bioengineers at the University of California San Diego have unraveled key mechanisms behind the mysteries of aging. They isolated two distinct paths that cells travel during aging and engineered a new way to genetically program these processes to extend lifespan.

16 Jul 2020

New discovery helps explain heart defects in Barth syndrome

The heart needs energy to pump blood. So, energy production defects in heart muscles result in a variety of cardiac diseases.

7 Jul 2020

UCLA scientists identify new function for histones

UCLA scientists have identified a new function for histones, the spool-shaped proteins that regulate gene expression and serve as anchors for strands of DNA to wrap around.

2 Jul 2020

New approach holds incredible potential for developing new therapeutics

Nearly every drug that is, or has ever been, used was derived from nature -- harnessing compounds created by organisms over eons to fight diseases. But decades ago, biochemists postulated that it might be possible to design a new drug from scratch by linking up amino acids in precise ways.

30 Jun 2020

Glitches in DNA replication have important implications for treating cancer

USC researchers peering deep inside a living cell have discovered something surprising: Its system for preventing genetic damage linked to diseases can fail so badly that the cell would be better off without it.

30 Jun 2020

Structured 'cut-and-paste' design enables streamlined development of SARS-CoV-2 molecular probes

A seminal study by US researchers, currently available on the bioRxiv* preprint server, demonstrates how structure-based design can be efficiently employed to develop molecular probes targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike and its domains, with possible future use in diagnostics, treatment and vaccine development.

24 Jun 2020

Improving cancer therapies by exploiting drug resistance in cancer

News-Medical talks to Professor David Thomas about his recent research identifying the mechanisms behind cancer cells developing resistance to drugs.

23 Jun 2020

New method for producing tsetse fly attractants using biotechnology

The tsetse fly occurs in large regions of sub-Saharan Africa. The flies feed on human and animal blood, transmitting trypanosoma in the process - small, single-cell organisms that use the flies as intermediate host and cause a dangerous inflammation of the lymph and nervous system in both animals and humans.

22 Jun 2020

Mutational targets of SARS-CoV-2 receptor-binding domain for vaccine-antiviral development

The COVID-19 pandemic has spread throughout the whole world within six months, causing millions of infections and hundreds of thousands of deaths. Yet there is no effective vaccine or antiviral to deal with it.

18 Jun 2020

Study: Vitamin D can reduce side effects associated with chemotherapy

As many cancer patients will confirm, the chemotherapy prescribed to kill the disease is often more debilitating than the cancer itself, with a range of horrendous side effects.

18 Jun 2020

Japanese health supplement could help tackle Covid-19 in people with comorbid conditions

A unique Beta 1,3-1,6 Glucan based Japanese health supplement, produced by black yeast, Aureobasidium Pullulans, could strategically help tackle Covid-19 in people with comorbid conditions like diabetes, kidney and heart diseases, as published in Frontiers in Immunology Journal recommending clinical studies, for validation.

18 Jun 2020

An improved tetravalent antibody blocks SARS-CoV-2 infection

A new study published on the preprint server bioRxiv* in June 2020 shows the potential of a new fusion molecule called a biparatopic protein to inhibit viral interaction with the host cell ACE2 receptor. This could lead to therapeutic applications.

17 Jun 2020