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New orthotopic model recapitulates more closely metastatic steps in Ewing sarcoma

The Sarcoma research group of Bellvitge Biomedical Research Institute, led by Dr. Òscar Martínez-Tirado, has developed a modified version of an orthotopic model that allows researchers to recreate more closely the metastatic steps in Ewing sarcoma (ES), the second most common bone tumor in children and adolescents.

30 Aug 2016

Large cardiopoietic regenerative therapy trial for patients with congestive heart failure reveals new insights

A therapy that uses bone-marrow stem cells to promote heart repair did not significantly improve the primary outcome over a sham procedure among patients with congestive heart failure.

29 Aug 2016

Blade implants in oral surgery still successful after 50 years

Journal of Oral Implantology – For nearly 50 years, the unique design of the blade implant and the ease of inserting it into a patient’s mouth have made it popular among oral surgeons. As the implant’s golden jubilee approaches, some of its original designers take a new look at a creation that has “passed the test of time.”

29 Aug 2016

Janssen seeks to extend DARZALEX license to benefit more multiple myeloma patients

Janssen-Cilag International NV has announced the submission of a Type II variation application to the European Medicines Agency (EMA), seeking to broaden the existing marketing authorisation for the immunotherapy DARZALEX® (daratumumab) to include treatment of adult patients with relapsed multiple myeloma who have received at least one prior therapy. The expanded indication is based on daratumumab in combination with lenalidomide (an immmunomodulatory agent) and dexamethasone, or bortezomib (a PI) and dexamethasone.

29 Aug 2016

Study results confirm safety and efficacy of INSIGHTEC’s Exablate Neuro system for the treatment of essential tremor

INSIGHTEC, the leader in MR-guided Focused Ultrasound (MRgFUS) therapy, has announced that the New England Journal of Medicine (NEJM) has published the results of a pivotal study of their Exablate Neuro system for the non-invasive treatment of essential tremor (ET). The study met its primary endpoint with patients treated with Exablate Neuro demonstrating a clinically significant 47% improvement in a composite tremor score at three months as compared to no change in the sham cohort.

29 Aug 2016

Researchers find new way for early prediction of leukemic relapse

Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified RNA-based biomarkers that distinguish between normal, aging hematopoietic stem cells and leukemia stem cells associated with secondary acute myeloid leukemia (sAML), a particularly problematic disease that typically afflicts older patients who have often already experienced a bout with cancer.

26 Aug 2016

New biomaterial allows scientists to study how stem cells sense stiffness of surrounding environment

A new biomaterial can be used to study how and when stem cells sense the mechanics of their surrounding environment, found a team led by Robert Mauck, PhD, the Mary Black Ralston Professor for Education and Research in Orthopaedic Surgery, in the Perelman School of Medicine at the University of Pennsylvania.

26 Aug 2016

Breakthrough in cancer cell screening advances personalised treatment of childhood leukaemia

Researchers at Newcastle University have been able to accurately predict how children whose cancer returns after treatment for leukaemia are likely to respond to further treatment.

26 Aug 2016

Research findings pave way to effective strategies for treatment of visceral leishmaniasis

A study shows that stimulating the production of interleukin-17A (IL-17A), one of the cytokines released by cells of the immune system, can be an effective strategy for the treatment of visceral leishmaniasis, considered one of the six most important parasitic diseases affecting humans.

25 Aug 2016

Protein complex could play key role in natural development of stem cells into healthy blood cells

A group of proteins best known for helping to activate all mammalian genes has been found to play a particularly commanding role in the natural development of specialized stem cells into healthy blood cells, a process known as hematopoiesis.

25 Aug 2016

Researchers discover novel pathway for immune recovery following bone-marrow transplantation

New research has shown how a cell surface molecule, Lymphotoxin β receptor, controls entry of T-cells into the thymus; and as such presents an opportunity to understanding why cancer patients who undergo bone-marrow transplant are slow to recover their immune system.

25 Aug 2016

New imaging technique may help detect amyloid-related heart failure

A type of heart failure caused by a build-up of amyloid can be accurately diagnosed and prognosticated with an imaging technique, eliminating the need for a biopsy, according to a multicenter study led by researchers at Columbia University Medical Center.

24 Aug 2016

Assigning barcode to stem cells makes it possible to monitor large blood cell populations

By assigning a barcode to stem cells, researchers at Lund University in Sweden have made it possible to monitor large blood cell populations as well as individual blood cells, and study the changes over time.

24 Aug 2016

Tendon transfer for quadriplegics greatly underused, article reveals

A surgery for quadriplegics called tendon transfer can significantly improve hand and elbow function, but the procedure is greatly underused, according to an article in the journal Hand Clinics by Loyola Medicine hand surgeon Michael S. Bednar, MD, FAAOS.

24 Aug 2016

Researchers investigate link between diet, obesity-linked Type 2 diabetes, and spinal disc degeneration

Can a diet high in processed fat and sugar and Type 2 diabetes cause degeneration of intervertebral discs in the spine? If so, what is happening, and can it be prevented? As part of an ongoing collaboration between Rensselaer Polytechnic Institute and the Icahn School of Medicine at Mount Sinai - a partnership that draws upon the expertise of both schools to address significant health problems - researchers hope to answer those questions by investigating the link between diet, obesity-linked Type 2 diabetes, and intervertebral disc degeneration.

23 Aug 2016

TMDU researchers inject gelatin-based gel carrying protein/peptide drugs to trigger bone augmentation

The part of the jawbone containing tooth sockets is known as alveolar bone, and its loss over time or following dental disease may ultimately result in tooth loss.

23 Aug 2016

Research finding opens door to new treatment options for inflammatory rheumatism

Enthesitis, inflammation of tendons where they attach to the bone, is a common medical problem which underlies various forms of inflammatory rheumatism.

23 Aug 2016

Soluble corn fiber can help build and retain calcium in bone during adolescence and post-menopause

Supplementing with soluble corn fiber at two critical times in a woman's life - adolescence and post-menopause - can help build and retain calcium in bone, according to new research from Purdue University.

23 Aug 2016

$Study looks at ways to reduce prescription drugs linked to fracture risk among older adults$

Study looks at ways to reduce prescription drugs linked to fracture risk among older adults

Fragility fractures -- those that occur at standing height -- are a significant source of sickness and death among the elderly population in the United States. They are also associated with annual direct costs of over $16 billion.

23 Aug 2016

Penn researchers uncover strategy to reverse effects of dyskeratosis congenita

Dyskeratosis congenita, or DC, is a rare, inherited disease for which there are limited treatment options and no cure.

18 Aug 2016

Bone News and Research

New orthotopic model recapitulates more closely metastatic steps in Ewing sarcoma

Large cardiopoietic regenerative therapy trial for patients with congestive heart failure reveals new insights

Blade implants in oral surgery still successful after 50 years

Janssen seeks to extend DARZALEX license to benefit more multiple myeloma patients

Study results confirm safety and efficacy of INSIGHTEC’s Exablate Neuro system for the treatment of essential tremor

Researchers find new way for early prediction of leukemic relapse

New biomaterial allows scientists to study how stem cells sense stiffness of surrounding environment

Breakthrough in cancer cell screening advances personalised treatment of childhood leukaemia

Research findings pave way to effective strategies for treatment of visceral leishmaniasis

Protein complex could play key role in natural development of stem cells into healthy blood cells

Researchers discover novel pathway for immune recovery following bone-marrow transplantation

New imaging technique may help detect amyloid-related heart failure

Assigning barcode to stem cells makes it possible to monitor large blood cell populations

Tendon transfer for quadriplegics greatly underused, article reveals

Researchers investigate link between diet, obesity-linked Type 2 diabetes, and spinal disc degeneration

TMDU researchers inject gelatin-based gel carrying protein/peptide drugs to trigger bone augmentation

Research finding opens door to new treatment options for inflammatory rheumatism

Soluble corn fiber can help build and retain calcium in bone during adolescence and post-menopause

Study looks at ways to reduce prescription drugs linked to fracture risk among older adults

Penn researchers uncover strategy to reverse effects of dyskeratosis congenita

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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