Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

NEB introduces NEBNext Quick DNA Sample Prep Reagent Set 2, Master Mix Set 2

New England Biolabs has expanded its line of reagents for sample preparation with the introduction of NEBNext Quick DNA Sample Prep Reagent Set 2 and Master Mix Set 2, both suitable for library construction for Roche's 454 GS FLX Titanium and GS Junior instruments. These new products provide all the necessary enzymes and buffers for fast fragment library preparation.

From New England Biolabs 14 Jul 2010

Researchers investigate oral cancer, periodontal disease relationship

Today during the 88th General Session & Exhibition of the International Association for Dental Research, in Barcelona, Spain, presenting author J. Meyle, Justus Liebig University, Giessen, Germany, will present an abstract titled "P. gingivalis Infection and Immune Evasion of Oral Carcinomas."

14 Jul 2010

GWAS suggests genetic variant with increased oncogene expression for cancer study

The study, published July 13th in Genome Research, showcases a new protocol for studying the activity of cancer-risk variants suggested by GWAS studies. The results also underscore the dramatic consequences of small genetic changes even in the vast stretches of DNA, known as "gene deserts," that do not code for proteins.

13 Jul 2010

Subtle mutation affecting epigenome may lead to inherited form of mental retardation: Researchers

A subtle mutation affecting the epigenome –- a set of dynamic factors that influence gene activity -- may lead to an inherited form of mental retardation that affects boys, find researchers at Children's Hospital Boston. The disorder, which also involves cleft lip or cleft palate, appears to hinge on an enzyme working in a biological pathway that may offer several potential drug targets.

12 Jul 2010

Promising study may lead to potential new therapeutics for women facing triple-negative breast cancer

Using a small molecule decoy, investigators funded by the Samuel Waxman Cancer Research Foundation have managed to block protein interactions and induce epigenetic reprogramming in human and mouse breast cancer cells, essentially changing the gene expression of breast cancer cells to behave in a more normal manner.

9 Jul 2010

Musashi 2 protein predicts progression of AML and CML, identify researchers

Researchers at Whitehead Institute and Children's Hospital Boston have identified a protein, called Musashi 2, that is predictive of prognosis in acute myeloid leukemia and chronic myeloid leukemia patients.

9 Jul 2010

Research findings may help scientists understand how muscle and heart diseases develop

Researchers from Mount Sinai School of Medicine have identified a previously unknown mechanism by which cells direct gene expression, the process by which information from a gene is used to direct the physical and behavioral development of individuals. The research, which may help scientists gain insight into how muscle and heart diseases develop, is published in the July 8th issue of Nature.

9 Jul 2010

WaferGen Biosystems announces closing of $7.2M registered direct offering

WaferGen Biosystems, Inc., a leading developer of state-of-the-art genomic analysis systems, today announced the closing of a $7.2 million registered direct offering. The amount raised includes $1 million from the Chairman and CEO, Alnoor Shivji, and approximately $500,000 in the aggregate from four other members of the board of directors of WaferGen.

9 Jul 2010

MicroRNA-212 plays key role in determining vulnerability to cocaine addiction: Study

Scientists from The Scripps Research Institute have found that a particular type of genetic material plays a key role in determining vulnerability to cocaine addiction and may offer an entirely new direction for the development of anti-addiction therapies. In animal studies, the scientists found that a molecule called microRNA-212 was increased in the brains of test animals that had extended access to cocaine.

8 Jul 2010

Silence strengthens RNAi IP portfolio with issuance of key patent in structural modification technology

Silence Therapeutics plc announces the issuance of United States patent 7,750,144, titled Methods and Compositions for Enhancing Efficacy and Specificity of RNA Silencing, by the United States Patent and Trademark Office (USPTO). The issued patent generally claims methods of producing double stranded (RNAi) agents having decreased off-target silencing activity through certain structural modifications. The ability to minimize the off-target effects of RNAi therapeutics is critical for controlling unwanted cellular activity and/or potential safety concerns.

8 Jul 2010

Slow rate of living and reduced energy metabolism is sufficient to increase longevity: Study

Don't put down the red wine and vitamins just yet, but if you're taking antioxidants because you hope to live longer, consider this: a new study published in the June 2010 issue of the journal GENETICS casts doubt on the theory that oxidative stress to our tissues shortens lifespan. That's because researchers from McGill University in Canada have identified mutations in 10 different genes of worms (genes believed to have counterparts in humans) that extend their lifespan without reducing the level of oxidative stress the worms suffer.

7 Jul 2010

Phase Ia clinical trial of SYL040012 for treating elevated intraocular pressure, glaucoma completed

Sylentis, a biopharmaceutical subsidiary of Grupo Zeltia and a pioneer in the research and development of new drugs based on gene silencing (interference RNA, RNAi), has completed Phase Ia of its first clinical trial with SYL040012 in the form of ophthalmic drops to treat elevated intraocular pressure and glaucoma.

7 Jul 2010

Preclinical efficacy data of Sangamo's ZFN based human stem cell therapy for HIV published

Sangamo BioSciences, Inc. announced the publication of data demonstrating the preclinical efficacy of a human stem cell therapy for human immunodeficiency virus (HIV) based on its proprietary zinc finger DNA-binding protein nuclease (ZFN) technology.

6 Jul 2010

Mount Sinai Hospital researchers discover new insights into genesis of stem cells

Mount Sinai Hospital researchers including Drs. Andras Nagy and Jeff Wrana have discovered new insights into the genesis of stem cells, which will improve the efficiency of stem cell creation for use in tissue regeneration and in the development of new drugs.

3 Jul 2010

WaferGen Biosystems to raise $7 million in registered direct offering

WaferGen Biosystems, Inc., a leading developer of state-of-the-art genomic analysis systems, today announced that it has received commitments from certain investors to purchase approximately $7 million of previously unissued securities in a registered direct offering. The investors include the Chairman and CEO, Alnoor Shivji, who has agreed to purchase $1 million of securities in the registered direct offering.

2 Jul 2010

Babies born after IVM fertility treatment more likely to be born larger than normal

A review of studies of babies born after in vitro maturation (IVM) fertility treatment has suggested that they are more likely to be born larger than normal and to have more difficult births requiring more obstetric interventions such as caesareans.

1 Jul 2010

Data published in Cancer Research demonstrates proof of concept for Mirna's tumor suppressor miRNAs

Mirna Therapeutics announced today publication of new results in the journal Cancer Research demonstrating proof of concept that the systemic delivery of tumor suppressor microRNAs (miRNA) inhibits tumor growth by restoring the proper regulatory pathways required for cell cycle arrest and apoptosis.

30 Jun 2010

Serotonin promotes beta cell expansion during pregnancy, offers possible cure for type 1 diabetes

Researchers funded by JDRF have discovered that the hormone, serotonin, may be involved in the increase of insulin-producing beta cells during pregnancy.

29 Jun 2010

Mammalian embryo use different strategies to suppress retroviral infection: Study

Some viruses insert themselves into the host's DNA during infection in a process called retroviral integration, causing several diseases, including AIDS and cancer, notes a Texas A&M researcher who specializes in fetal diseases.

29 Jun 2010

Signature Dx obtains worldwide license to Affymetrix microarray technology for development of CRC tests

Affymetrix, Inc. and Signature Diagnostics AG today announced that they have signed a Powered by Affymetrix™ (PbA) agreement. Under the agreement, Signature Dx obtains a worldwide license to use Affymetrix® microarray technology to develop and commercialize diagnostic and prognostic colorectal cancer (CRC) tests.

29 Jun 2010

Gene Expression News and Research

Further Reading

NEB introduces NEBNext Quick DNA Sample Prep Reagent Set 2, Master Mix Set 2

Researchers investigate oral cancer, periodontal disease relationship

GWAS suggests genetic variant with increased oncogene expression for cancer study

Subtle mutation affecting epigenome may lead to inherited form of mental retardation: Researchers

Promising study may lead to potential new therapeutics for women facing triple-negative breast cancer

Musashi 2 protein predicts progression of AML and CML, identify researchers

Research findings may help scientists understand how muscle and heart diseases develop

WaferGen Biosystems announces closing of $7.2M registered direct offering

MicroRNA-212 plays key role in determining vulnerability to cocaine addiction: Study

Silence strengthens RNAi IP portfolio with issuance of key patent in structural modification technology

Slow rate of living and reduced energy metabolism is sufficient to increase longevity: Study

Phase Ia clinical trial of SYL040012 for treating elevated intraocular pressure, glaucoma completed

Preclinical efficacy data of Sangamo's ZFN based human stem cell therapy for HIV published

Mount Sinai Hospital researchers discover new insights into genesis of stem cells

WaferGen Biosystems to raise $7 million in registered direct offering

Babies born after IVM fertility treatment more likely to be born larger than normal

Data published in Cancer Research demonstrates proof of concept for Mirna's tumor suppressor miRNAs

Serotonin promotes beta cell expansion during pregnancy, offers possible cure for type 1 diabetes

Mammalian embryo use different strategies to suppress retroviral infection: Study

Signature Dx obtains worldwide license to Affymetrix microarray technology for development of CRC tests

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