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Using zebrafish to discover and identify new drugs to treat spinal cord lesions

A research team led by Leonor Saúde, Principal Investigator at Instituto de Medicina Molecular, in partnership with the company Technophage, SA, has designed a simple and efficient platform that uses zebrafish to discover and identify new drugs to treat spinal cord lesions.

22 Jul 2019

New organic molecule could become potent weapon in the fight against antibiotic resistance

An organic molecule composed of simple sugars could become a potent weapon in the fight against rising antibiotic resistance, according to EU-funded researchers who have developed a novel, targeted drug-delivery technique to treat deadly tuberculosis and other lethal pathogens.

21 Jul 2019

Disruption of immune cell behavior may spur heart disease, heart failure

On an ice hockey team, the players all start off with identical uniforms, skates and a stick. But if you take one of them, add padding, a glove, and a mask; and switch the stick to one with a larger blade, then you get a goalie.

From Johns Hopkins Medicine 19 Jul 2019

How genetic differences in Epstein-Barr virus strains alter the way it behaves

Researchers at the University of Sussex have identified how differences in the genetic sequence of the two main strains of the cancer-associated Epstein-Barr virus can alter the way the virus behaves when it infects white blood cells.

19 Jul 2019

Receptor in the uterus can detect sperm molecule, aids in sperm survival

Why does it take 200 million sperms to fertilize a single egg? The single sperm that reached the finished line has successfully survived multiple checkpoints within the female reproductive tract, dubbed as pre-fertilization events. Now, a new study shows that the uterus contains receptors that facilitate sperm survival.

19 Jul 2019

Researchers develop a more precise version of CRISPR-Cas9 gene-editing system

A gene defect in humans causes progressive hearing loss in humans, resulting in deafness by their mid-20s. The same genetic mutation causes deafness in the Beethoven-mouse model.

18 Jul 2019

Study defines how diarrhea-causing rotavirus initially interacts with the host

Research by the Department of Microbiology of the University of Valencia, the Institute of Biomedicine of Valencia and the Institute of Agrochemistry and Food Technology of the CSIC has defined the initial interaction of human rotavirus P [8] (the main cause of gastroenteritis) with the recipients of the intestine.

18 Jul 2019

Novel insight into microRNA function can be crucial for the development of gene therapy

Scientists at the University of Eastern Finland and the University of Oxford have shown that small RNA molecules occurring naturally in cells, i.e. microRNAs, are also abundant in cell nuclei.

18 Jul 2019

New drug-delivery system disguises chemotherapeutics as fat to outsmart tumors

A stealthy new drug-delivery system disguises chemotherapeutics as fat in order to outsmart, penetrate and destroy tumors.

18 Jul 2019

Rare inherited enzyme disorder offers new clues about fibrotic conditions

What can a family of rare inherited disorders teach scientists about more common health problems like fibrosis? Plenty, based on research led by St. Jude Children's Research Hospital scientists that appears today in the journal Science Advances.

17 Jul 2019

Antioxidant precursor molecule could improve dopamine levels in Parkinson's patients

N-acetylcysteine (NAC) is a naturally occurring molecule that replenishes one of the body's antioxidants and now shows potential benefit as part of a standard course of treatment for patients with Parkinson's disease, according to a study published in the journal, Clinical Pharmacology & Therapeutics.

16 Jul 2019

Human pancreas on a chip could help identify possible cause of CF-Related Diabetes

Scientists created human pancreas on a chip that allowed them to identify the possible cause of a frequent and deadly complication of cystic fibrosis (CF) called CF-Related Diabetes, or CFRD.

16 Jul 2019

New 'molecular scaffolding' could help restore sight loss caused by glaucoma

Fight for Sight is funding scientists at the University of Cambridge to research how a new ‘molecular scaffolding’ could help restore vital nerve connections between the eye and the brain, potentially recovering the sight loss caused by glaucoma and other conditions, and even paving the way for future eye transplants.

16 Jul 2019

New chemBIOS platform for drug development

In spite of increasing demand, the number of newly developed drugs decreased continuously in the past decades.

15 Jul 2019

New insights into molecular motors could help treat neurological disorders

Nerve cells form the basis of the nervous system in animals, as they transfer information between the various sensory and effector organs of the body and the brain and spinal cord. However, this function relies heavily on the transport of several proteins and other molecules between various parts of the cell.

15 Jul 2019

Reprogramming cells to control HIV infection

Cells from the rare individuals who naturally control HIV infection have been the focus of investigation for nearly 15 years with the aim of elucidating their specific features.

14 Jul 2019

How cell-free DNA can be targeted to prevent spread of tumors

Cell-free DNA (cfDNA) is DNA found in trace amounts in blood, which has escaped degradation by enzymes.

12 Jul 2019

Alternate cell growth pathway could open door to new treatments for metastatic cancers

While researchers have a basic understanding of how primary cancer cells grow, less is known about metastasis, the deadly process by which cancers spread.

12 Jul 2019

Tomocube HT microscope enables label-free quantification of cellular lipid content

In a breakthrough for research fields as diverse as diabetes, atherosclerosis and biofuels, the mass, concentration, volume, and surface area of individual lipid droplets have been measured in live, unstained cells for the first time using a Tomocube Holotomography microscope.

From Tomocube Inc. 12 Jul 2019

Scientists study immune molecules inside mycetoma grains

Mycetoma is a common neglected disease caused by either fungi or bacteria which organize themselves into grains—areas of inflammation surrounded by a collagen capsule.

From PLOS ONE 12 Jul 2019