Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Researchers discover potential target for cancer-fighting drugs

As tumors grow, their centers are squeezed of oxygen. And so tumors must flip specific genetic switches to survive in these hypoxic environments.

10 Jun 2013

Human Argonautes directly cuts messenger RNA

Human Argonautes (hAgo), are key proteins involved in a process known as RNA interference. RNAi, as it is often called, is a mechanism that cells use to regulate gene expression.

7 Jun 2013

Changes in normal glycan behavior lead to fatal lysosomal disease, say researchers

From the neurons that enable thought to the keratinocytes that make toenails grow-a complex canopy of sugar molecules, commonly known as glycans, envelop every living cell in the human body.

6 Jun 2013

Scientists suggest that Oprl1 receptor is altered in mice with PTSD-like symptoms

When injected into mice immediately following a traumatic event, a new drug prevents the animals from developing memory problems and increased anxiety that are indicative of post-traumatic stress disorder.

6 Jun 2013

Study suggests modulation of "enhancer-directed RNAs" can alter gene expression in living cells

In a pair of distinct but complementary papers, researchers at the University of California, San Diego School of Medicine and colleagues illuminate the functional importance of a relatively new class of RNA molecules.

5 Jun 2013

EORTC BOS 2 trial to test efficacy of adding bevacizumab to peri-operative FOLFOX 4 chemotherapy

Colorectal cancer (CRC) is the second most frequent cause of cancer-related mortality in both Europe and the United States. Treatment for patients with resectable hepatic metastases from colorectal cancer consists of surgery combined with chemotherapy, but recurrence is observed in two thirds of these patients.

5 Jun 2013

Better understanding of breast milk variability, strategies for optimizing neonatal diet

The composition of breast milk varies from mother to mother, and genetic factors may affect the levels of protective components in breast milk that could influence a newborn's outcomes.

5 Jun 2013

Diaxonhit, XDx agree to market and perform AlloMap Molecular Expression Testing in Europe

Diaxonhit, the leading French provider of specialty diagnostic solutions, and XDx, Inc., a U.S. molecular diagnostics company focused on non-invasive tests for transplantation and autoimmune disease, announced today that they have entered into a memorandum of agreement for the exclusive license to market and perform AlloMap Molecular Expression Testing (AlloMap) in Europe.

4 Jun 2013

Gene expression test measures risk of metastases in breast cancer patients

In Austria every year approx. 1,500 postmenopausal patients, that is, after the climacteric period, are affected by stage II breast cancer. This means that in these women tumour cells have already been found in the lymph nodes and that the risk of metastases appearing in the future course of the illness is significantly increased.

4 Jun 2013

Study brings researchers one step closer to personalized colorectal cancer treatment

MET protein levels correlate strongly with epithelial-mesenchymal transition phenotype, a treatment-resistant type of colorectal cancer and may be used as a surrogate biomarker, according to new research from The University of Texas MD Anderson Cancer Center.

4 Jun 2013

Researchers identify a new mechanism that appears to suppress tumor growth

Researchers at the University of California, San Diego School of Medicine, with colleagues at the University of Rochester Medical Center, have identified a new mechanism that appears to suppress tumor growth, opening the possibility of developing a new class of anti-cancer drugs.

4 Jun 2013

Scientists pinpoint genetic traits of cells that give rise to gliomas

A multi-institutional team of researchers have pinpointed the genetic traits of the cells that give rise to gliomas - the most common form of malignant brain cancer. The findings, which appear in the journal Cell Reports, provide scientists with rich new potential set of targets to treat the disease.

4 Jun 2013

Study investigates gene expression signature to predict response to bevacizumab

A new test may help identify newly diagnosed glioblastoma patients more likely to benefit from bevacizumab (Avastin-), according to new research from The University of Texas MD Anderson Cancer Center.

3 Jun 2013

Mount Sinai researchers present landmark studies at ASCO meeting

Icahn School of Medicine at Mount Sinai researchers will present several landmark studies at the 2013 American Society of Clinical Oncology meeting May 31-June 4, 2013 in Chicago, including data on the likelihood of spousal human papillomavirus oral infection, new gene signatures in melanoma, and issues with high readmission rates after cancer surgery.

3 Jun 2013

Findings could potentially lead to new drug therapy for Cushing disease

Cushing disease is a life-threatening disorder most commonly triggered by tumors, often benign, in the pituitary glands, resulting in excess production of adrenocorticotrophic hormone.

1 Jun 2013

Calyx of Held: The largest synapse could shed light on neuropsychiatric disorders

Humans and most mammals can determine the spatial origin of sounds with remarkable acuity. We use this ability all the time -- crossing the street; locating an invisible ringing cell phone in a cluttered bedroom.

27 May 2013

Potential new treatment approaches for liver diseases

By discovering the new mechanism by which estrogen suppresses lipid synthesis in the liver, UC Irvine endocrinologists have revealed a potential new approach toward treating certain liver diseases.

24 May 2013

EGFR gums up cell's miRNA-processing machinery under oxygen starvation conditions

Even while being dragged to its destruction inside a cell, a cancer-promoting growth factor receptor fires away, sending signals that thwart the development of tumor-suppressing microRNAs before it's dissolved, researchers reported in an early online publication at Nature.

24 May 2013

iBio announces production of vaccine candidate for new H7N9 influenza virus

iBio, Inc. today announced the production of a vaccine candidate for the newly emerged H7N9 influenza virus by an independent third party laboratory using the iBioLaunch platform.

22 May 2013

Video demonstrating a SPE microplate method for reproducible isolation of high quality RNA released by INTEGRA

INTEGRA has released a new video demonstrating a solid phase extraction (SPE) microplate method for reproducible, high throughput isolation of high-quality DNA-free total RNA.

From INTEGRA Biosciences 22 May 2013

Gene Expression News and Research

Further Reading

Researchers discover potential target for cancer-fighting drugs

Human Argonautes directly cuts messenger RNA

Changes in normal glycan behavior lead to fatal lysosomal disease, say researchers

Scientists suggest that Oprl1 receptor is altered in mice with PTSD-like symptoms

Study suggests modulation of "enhancer-directed RNAs" can alter gene expression in living cells

EORTC BOS 2 trial to test efficacy of adding bevacizumab to peri-operative FOLFOX 4 chemotherapy

Better understanding of breast milk variability, strategies for optimizing neonatal diet

Diaxonhit, XDx agree to market and perform AlloMap Molecular Expression Testing in Europe

Gene expression test measures risk of metastases in breast cancer patients

Study brings researchers one step closer to personalized colorectal cancer treatment

Researchers identify a new mechanism that appears to suppress tumor growth

Scientists pinpoint genetic traits of cells that give rise to gliomas

Study investigates gene expression signature to predict response to bevacizumab

Mount Sinai researchers present landmark studies at ASCO meeting

Findings could potentially lead to new drug therapy for Cushing disease

Calyx of Held: The largest synapse could shed light on neuropsychiatric disorders

Potential new treatment approaches for liver diseases

EGFR gums up cell's miRNA-processing machinery under oxygen starvation conditions

iBio announces production of vaccine candidate for new H7N9 influenza virus

Video demonstrating a SPE microplate method for reproducible isolation of high quality RNA released by INTEGRA

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