Liver News and Research

RSS

Study elucidates mechanism behind development of steroid diabetes

Steroids are used for treating various diseases such as allergic disorders, but they occasionally cause adverse effects, such as steroid diabetes and other metabolic disturbances. Since steroids act throughout the body, how these adverse effects are caused and by which organ are not well understood.

28 Feb 2019

Researchers are developing and testing novel gene therapy to cure Crigler-Najjar syndrome

Crigler-Najjar syndrome affects about one in a million people at birth. Because of a defective gene, these individuals lack an essential enzyme in their liver to eliminate bilirubin, a toxic bile pigment that accumulates in all body tissues causing jaundice and potentially leading to irreversible and lethal neurological damage.

28 Feb 2019

Key to treat deadly cancers could lie deep within complex machinery of human cell

Buried deep within the dazzlingly intricate machinery of the human cell could lie a key to treating a range of deadly cancers, according to a team of scientists at Florida State University.

27 Feb 2019

Philips unveils unique mixed reality concept developed jointly with Microsoft at MWC Barcelona

At the MWC Barcelona, one of the largest mobile events in the world, Royal Philips, a global leader in health technology today unveiled a unique mixed reality concept developed together with Microsoft Corp. for the operating room of the future.

26 Feb 2019

Successful testing of multi-organ "human-on-a-chip" could replace animals as test subjects

The replacement of animals as test subjects is one step closer to reality with the successful testing of multi-organ "human-on-a-chip" models to recapitulate the 28-day experiments typically used in animals to evaluate the systemic toxicity of drug and cosmetic compounds.

22 Feb 2019

Vitamin D supplementation less effective in the presence of obesity, shows study

A new Journal of Bone and Mineral Research study confirms that vitamin D supplementation is less effective in the presence of obesity, and it uncovers a biological mechanism to explain this observation.

21 Feb 2019

Genetic defect linked to pediatric liver disease identified

Researchers from the University of Colorado Anschutz Medical Campus, in collaboration with several other institutions, have discovered a genetic defect linked to Biliary atresia, the most common pediatric cause of end-stage liver disease, and the leading indication for liver transplantation in children.

21 Feb 2019

Artificial intelligence technique can be used to identify alcohol misuse in trauma setting

A first-of-its kind study has demonstrated that an artificial intelligence technique can be used to identify trauma patients who misuse alcohol.

21 Feb 2019

Drug increases melanin production in some people with albinism

A small pilot clinical study at the National Eye Institute suggests that the drug nitisinone increases melanin production in some people with oculocutaneous albinism type 1B, a rare genetic disease that causes pale skin and hair and poor vision.

21 Feb 2019

Intense exercise, fasting and hormones can enhance waste-protein removal, study shows

The body's ability to adapt to changing conditions and shifting physiologic demands is essential to survival. To do so, each cell must be able to dispose of damaged or unnecessary proteins--a quality-control mechanism critical for cellular performance and for the health of the entire organism.

21 Feb 2019

Study quantifies hepatic and intestinal mRNA expression of Ugt isoforms in rats

In pharmaceutical companies, rats are used commonly in nonclinical studies to investigate the safety, efficacy, and pharmacokinetic profiles of drug candidates before they are entered into clinical studies. Most compounds administered via the oral route are metabolized in the liver and intestine, so the metabolism is a key determinant of pharmacokinetics.

20 Feb 2019

Researchers engineer stem cell with ‘suicide genes’ to induce cell death in all but beta cells

Researchers have been advancing methods to generate insulin-producing beta cells from pluripotent stem cells for the clinical treatment of type 1 diabetes.

20 Feb 2019

Rubicon level linked to inhibition of autophagic process

Autophagy is an important biological recycling mechanism that is used to maintain homeostasis within all types of animal tissue. Many studies have attempted to understand the relationship between the reduction of autophagy and progression of aging in animals; however, none have provided a clear explanation, until now.

20 Feb 2019

Common acid reflux drugs tied to elevated risk for kidney disease

Proton pump inhibitors, which include well-known brand names Prilosec, Nexium and Prevacid, are among the most commonly prescribed medications in the world. Approximately 10 percent of adults in the United States take these drugs for frequent heartburn, acid reflux and gastroesophageal reflux disease.

19 Feb 2019

Testosterone is not the only hormone needed for penis development

A new study has revealed that in addition to testosterone, the masculinization process involves a hormone called androsterone, which originates in other tissues.

15 Feb 2019

Large-scale clinical trial begins to study liver transplantation between people with HIV

The first large-scale clinical trial to study liver transplantation between people with HIV has begun at clinical centers across the United States. The HOPE in Action Multicenter Liver Study will determine the safety of this practice by evaluating liver recipients for potential transplant-related and HIV-related complications following surgery.

15 Feb 2019

Liver News and Research

Study elucidates mechanism behind development of steroid diabetes

Researchers are developing and testing novel gene therapy to cure Crigler-Najjar syndrome

Key to treat deadly cancers could lie deep within complex machinery of human cell

Philips unveils unique mixed reality concept developed jointly with Microsoft at MWC Barcelona

Successful testing of multi-organ "human-on-a-chip" could replace animals as test subjects

Vitamin D supplementation less effective in the presence of obesity, shows study

Genetic defect linked to pediatric liver disease identified

Artificial intelligence technique can be used to identify alcohol misuse in trauma setting

Drug increases melanin production in some people with albinism

Intense exercise, fasting and hormones can enhance waste-protein removal, study shows

Study quantifies hepatic and intestinal mRNA expression of Ugt isoforms in rats

Researchers engineer stem cell with ‘suicide genes’ to induce cell death in all but beta cells

Rubicon level linked to inhibition of autophagic process

Common acid reflux drugs tied to elevated risk for kidney disease

Testosterone is not the only hormone needed for penis development

Large-scale clinical trial begins to study liver transplantation between people with HIV

Platinum nanoparticles show selective toxicity against liver cancer cells

Use of liver grafts from older donors decreased despite better outcomes in recipients

Researchers develop powerful new approach to improve maturation of miniature kidneys

Study investigates the role of estrogen in controlling glucose homeostasis

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Latest News