Protein C News and Research

RSS

GABA transfer between skin cells promotes melanoma initiation

The transfer of a neurotransmitter from one type of skin cell to another (melanocytes to keratinocytes) altered electrical activity and promoted melanoma initiation in preclinical models, according to results published in Cancer Discovery, a journal of the American Association for Cancer Research.

9 Aug 2023

Hmga1 protein could be an important therapeutic target for osteoporosis

New research published in The FASEB Journal indicates that increasing the expression of a particular gene may help to prevent bone loss associated with postmenopausal osteoporosis.

9 Aug 2023

Mice lacking TMCO3 gene have shortened bones

Through next-generation sequencing, investigators have identified a mutation in the TMCO3 gene in two sisters with short stature.

9 Aug 2023

Deep-learning technology could help scientists to develop personalized immunotherapies and vaccines

Deep-learning technology developed by a team of Johns Hopkins engineers and cancer researchers can accurately predict cancer-related protein fragments that may trigger an immune system response.

9 Aug 2023

Mass spectrometry-based secretome approach reveals key players in astroglial barrier function

In neuroinflammation, immune cells such as leukocytes cross the blood-brain barrier. One key to this is the gelatinases matrix metalloproteinase (MMP)-2 and -9. Until now, the substrates of these enzymes involved in the process were unknown.

9 Aug 2023

Ebola virus forms "viral factories" to replicate inside host cells

New research in the journal Nature Communications gives scientists an important window into how Ebola virus replicates inside host cells.

9 Aug 2023

Researchers develop antibody drugs from tobacco plants for cancer treatment

For the first time in Thailand, lecturers at Chulalongkorn University's Faculty of Pharmaceutical Sciences have successfully developed antibody from tobacco plants with inhibitory effects on the growth of cancer cells in laboratory animals.

9 Aug 2023

Are mushrooms an effective early dietary intervention for Alzheimer’s Disease?

In a study published in the journal Foods, researchers reviewed available literature on the potential anti-Alzheimer's disease properties of mushrooms.

9 Aug 2023

What are some recent advancements in proteomics-driven pancreatic oncology research?

The application of proteomics-driven biomarkers for early detection, diagnosis, and treatment of pancreatic cancer.

9 Aug 2023

The impact of epigenetic features on breast cancer treatment and outcomes

The impact of epigenetic features on breast cancer treatment and outcomes.

9 Aug 2023

The effectiveness of antimicrobial mouthwashes in reducing viral load in saliva of COVID-19 patients

Researchers assess the effectiveness of three types of mouthwash in reducing the viral load of SARS-CoV-2 in the saliva of infected individuals.

9 Aug 2023

High-level BPA exposure may affect male fertility

Scientists discuss the effect of bisphenol A on human male fertility.

9 Aug 2023

Lyme disease bacteria adapt to animal hosts at the variant level, study finds

A study looks at the mechanisms behind genetic variation in the bacteria that cause Lyme disease. Lyme disease is the most common vector-transmitted disease in the United States, with around 476,000 human cases annually.

8 Aug 2023

Inflammation slows down the development of malaria parasites in bloodstream

Research led by the Peter Doherty Institute for Infection and Immunity (Doherty Institute) and the Kirby Institute found that inflammation in the body can slow down the development of malaria parasites in the bloodstream – a discovery that may constitute a potential new strategy for preventing or limiting severe disease.

8 Aug 2023

NLRP3 inflammasome plays a role in podocyte aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, "Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span."

8 Aug 2023

Nationwide Children's Hospital pioneers new gene therapy for Duchenne muscular dystrophy

In a landmark moment for the Abigail Wexner Research Institute at Nationwide Children's, a 5-year-old from Bellefontaine, Ohio, received the first dose of a recently approved gene therapy for Duchenne muscular dystrophy at Nationwide Children's Hospital, where the therapy was invented and initially tested.

8 Aug 2023

RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

Published online ahead of print in the journal Oncogene , a study led by Josep Villanueva, an Investigator at the Vall d'Hebron Institute of Oncology (VHIO), shows that the receptor for advanced glycation end-product (RAGE) plays a key role in cellular mechanisms of plasticity in mesenchymal triple-negative breast cancer (TNBC) that transform epithelial cells into mesenchymal cells as potent drivers of cancer cell proliferation and tumor invasion.

8 Aug 2023