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NHS hospitals may prioritize meeting 18-week target over clinical need, analysis shows

There's strong evidence of a 'threshold effect' in English hospitals' efforts to comply with the 18-week referral to treatment standard, concludes a long term data analysis of performance against the target, published online in the journal BMJ Quality & Safety.

5 Sep 2023

Targeting the ORAI1 calcium channel could provide new approach to treating oral cancer

An essential protein that acts as a gatekeeper for calcium entering cells promotes the growth of oral cancer and generates pain, according to a new study published in Science Signaling led by researchers at NYU College of Dentistry.

5 Sep 2023

Experts call for changes to how drugs are tested and labeled for people with obesity

A new opinion piece published in Health Affairs Forefront raises questions around current approaches to assess drug safety and effectiveness in people with obesity.

5 Sep 2023

New blood test pinpoints Parkinson's disease through mitochondrial DNA damage

Researchers have developed a new blood test that measures mitochondrial DNA damage as a potential marker for Parkinson's disease (PD). The study shows the test could aid in diagnosing PD and assessing responses to LRRK2 kinase inhibitors, which may help in reducing mitochondrial damage in PD patients.

4 Sep 2023

Gut microbes play a starring role in insulin resistance, opening doors for new diabetes treatments

The study reveals a strong association between gut microbial carbohydrate metabolism and insulin resistance, pointing to gut microbes as a key player in metabolic syndrome and type 2 diabetes. Targeting these microbial activities could offer a new therapeutic pathway for improving insulin resistance and overall metabolic health.

4 Sep 2023

Study highlights risks of high-dose naloxone in opioid overdose response

Whether regular distribution of two intranasal or intramuscular administrations of low-dose naloxone was effective and adequate in reversing opioid overdoses.

4 Sep 2023

New cancer therapy shows promise in mouse models, slows or reverses tumor growth

A new cancer therapy developed by Purdue University researchers attacks tumors by tricking cancer cells into absorbing a snippet of RNA that naturally blocks cell division.

4 Sep 2023

Silencing two genes can make cancer cells receptive to chemotherapy

Scientists from Queen Mary University of London have discovered two new genes that cause head and neck cancer patients to be resistant to chemotherapy, and that silencing either gene can make cancer cells previously unresponsive to chemotherapy subsequently respond to it.

4 Sep 2023

Marijuana users have elevated levels of cadmium and lead in their blood and urine

Recent study reveals marijuana users have elevated levels of harmful metals like cadmium and lead in their blood and urine. The findings raise questions about the long-term health impacts and the need for stronger regulation on contaminants in cannabis products.

3 Sep 2023

Oral diabetes drug semaglutide fights obesity in mice: A game-changer for human treatment?

The study reveals that oral semaglutide, a medication primarily used for type 2 diabetes, effectively reduces body weight and blood glucose levels in diet-induced obese mice. The findings suggest that this drug could be a promising treatment for obesity and offer a suitable animal model for future research.

3 Sep 2023

Study finds ways to improve medication adherence in breast cancer survivors

For roughly 80% of breast cancer survivors, treatment doesn't end with surgery, radiation and chemotherapy. Instead, for the next five to 10 years, doctors recommend that they take medication to block sex hormones, which can fuel tumor growth and spark recurrence.

1 Sep 2023

Scientists discover new role for liver tPA in regulating cholesterol levels

Despite advances in treatment for high cholesterol, heart disease remains the leading cause of death in the U.S. Scientists at the Medical College of Wisconsin (MCW) are investigating the role of a form of cholesterol called very-low-density lipoprotein – and their findings may lead to new treatment options in the future.

1 Sep 2023

Integrating HIV and addiction treatment improves outcomes for people who inject drugs in Russia

New research from Boston Medical Center found that providing pragmatic support, specifically rapid access to antiretroviral therapy, pharmacotherapy for opioid use disorder, and strengths-based case management, improved treatment outcomes for people with HIV who inject drugs in St. Petersburg, Russia.

1 Sep 2023

International consortium to study link between RSV infection and chronic respiratory tract diseases

UMC Utrecht will lead an international consortium that will try to answer a key question that's in the mind of many pediatricians, infectiologists, pulmonologists and other health professionals: "Why are children that had an RSV infection in early childhood at increased risk of developing asthma later in life?"

1 Sep 2023

Weighted lottery helps ensure equitable allocation of scarce COVID-19 medication

A program designed to ensure fairness and that people living in the most disadvantaged U.S. neighborhoods would be offered a scarce, potentially life-saving medication proved feasible in a large health system.

1 Sep 2023

Heart protective effect of red blood cells is enhanced by nitrate-rich vegetable diet

Red blood cells exposed to oxygen deficiency protect against myocardial infarction, according to a new KI study published in the Journal of Clinical Investigations.

1 Sep 2023

Statins may protect IBD patients from colorectal cancer, study finds

Cholesterol-lowering statins might protect patients with ulcerative colitis from developing and dying from colorectal cancer.

1 Sep 2023

Amgen to discuss application for LUMAKRAS® (sotorasib) for the treatment of KRAS G12C-positive NSCLC at FDA advisory committee meeting

Amgen today announced the U.S. Food and Drug Administration (FDA) Oncologic Drugs Advisory Committee (ODAC) will review data supporting the supplemental New Drug Application (sNDA) for the full approval of LUMAKRAS® (sotorasib) for adults with previously treated locally advanced or metastatic KRAS G12C-mutated non-small cell lung cancer (NSCLC) at a meeting on Oct. 5, 2023.

From AMGEN 1 Sep 2023

IBS researchers discover new insights into the regulation of fat metabolism

This is a significant development that brings hope to the one billion individuals with obesity worldwide. Researchers led by Director C. Justin LEE from the Center for Cognition and Sociality (CCS) within the Institute for Basic Science (IBS) have discovered new insights into the regulation of fat metabolism.

31 Aug 2023

Unique openings in specific ion channels could lead to development of selective drugs

Ion channels are attractive drug targets due to their importance in health and disease, but finding ways to target a specific ion channel selectively is a major challenge.

31 Aug 2023

Drugs News and Research

NHS hospitals may prioritize meeting 18-week target over clinical need, analysis shows

Targeting the ORAI1 calcium channel could provide new approach to treating oral cancer

Experts call for changes to how drugs are tested and labeled for people with obesity

New blood test pinpoints Parkinson's disease through mitochondrial DNA damage

Gut microbes play a starring role in insulin resistance, opening doors for new diabetes treatments

Study highlights risks of high-dose naloxone in opioid overdose response

New cancer therapy shows promise in mouse models, slows or reverses tumor growth

Silencing two genes can make cancer cells receptive to chemotherapy

Marijuana users have elevated levels of cadmium and lead in their blood and urine

Oral diabetes drug semaglutide fights obesity in mice: A game-changer for human treatment?

Study finds ways to improve medication adherence in breast cancer survivors

Scientists discover new role for liver tPA in regulating cholesterol levels

Integrating HIV and addiction treatment improves outcomes for people who inject drugs in Russia

International consortium to study link between RSV infection and chronic respiratory tract diseases

Weighted lottery helps ensure equitable allocation of scarce COVID-19 medication

Heart protective effect of red blood cells is enhanced by nitrate-rich vegetable diet

Statins may protect IBD patients from colorectal cancer, study finds

Amgen to discuss application for LUMAKRAS® (sotorasib) for the treatment of KRAS G12C-positive NSCLC at FDA advisory committee meeting

IBS researchers discover new insights into the regulation of fat metabolism

Unique openings in specific ion channels could lead to development of selective drugs

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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