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Combating leukemia cells by disrupting their energy maintenance mechanism

Acute myeloid leukemia, which affects blood and bone marrow cells, is a particularly dangerous form of cancer. More than half of patients under the age of 60 die.

17 Feb 2022

Nitazoxanide shows promise for COVID-19 treatment in animal model

In a recent study posted to the bioRxiv* pre-print server, researchers demonstrated that Nitazoxanide (NTZ), an oral drug, broadly inhibits replication of several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in preclinical models of infection.

13 Feb 2022

Single-cell sequencing provides detailed insight into early SARS-CoV-2 infection in the lungs

What is going on at the single-cell level in the first days of SARS-CoV-2 infection in the lungs?

9 Feb 2022

Innate immune specificity is driven by the nervous system, study suggests

Research led by Washington State University scientists supports a novel theory that the innate immune system people are born with can respond differently to specific pathogens.

9 Feb 2022

Gut microbiome modulation induces behavioral, cognitive changes in Alzheimer's disease model

New research in mice for the first time draws a definitive causal connection between changes in the gut microbiome to behavioral and cognitive changes in an animal model of Alzheimer's disease.

8 Feb 2022

Researchers develop 3D human spinal cord implants for treating paralyzed patients

For the first time in the world, researchers from Sagol Center for Regenerative Biotechnology at Tel Aviv University have engineered 3D human spinal cord tissues and implanted them in lab model with long-term chronic paralysis.

7 Feb 2022

Research shows minks mimic severe COVID-19 symptoms, including ARDS

Minks may be a suitable animal model for testing severe COVID-19 infections, finds a recent bioRxiv* preprint study. While mice and ferrets are used in preclinical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is currently no model specific to severe disease.

30 Jan 2022

Photobiomodulation may accelerate the healing of skin damage from radiation therapy

Light therapy may accelerate the healing of skin damage from radiation therapy by up to 50%, according to a recent University at Buffalo-led study.

27 Jan 2022

Early-stage alveolar epithelial cell necrosis linked to COVID-19-induced acute respiratory distress syndrome

A new study analyzed whether alveolar epithelial cell necrosis at an early stage SARS-CoV-2 infection and subsequent releases of damage-associated molecular patterns could aggravate COVID-19-associated acute respiratory distress syndrome.

27 Jan 2022

Study suggests synthetic SARS-CoV-2 S glycoprotein coated lipid vesicles are an effective vaccine candidate

In a new study, a team of researchers developed a vaccine candidate with the SARS-CoV-2 spike (S) glycoprotein coated onto lipid vesicles which resembles virus-like particles.

26 Jan 2022

Study shows monoclonal antibody and antiviral therapy are useful in preventing the severity of SARS-CoV-2 Omicron infection

In a new study, researchers assessed the efficacy of the FDA-approved therapeutic mAbs, as well as to small-molecule antiviral agents against the SARS-CoV-2 Omicron variant in Syrian hamsters.

21 Jan 2022

Research provides new insights on memory loss in Alzheimer's disease

Members of the "Synaptic Dysfunction and Disease" group at the Institute of Biomedicine of Seville, led by researchers Francisco Gómez Scholl and Amalia Martínez Mir, recently published the results of their research into Alzheimer's disease.

18 Jan 2022

Study reveals a causal link between deficiency in Parkinson’s disease gene and reduced immunoaging

A Parkinson’s disease gene turns out to provide the key to modify diseases related to immunoaging.

18 Jan 2022

Study reveals a causal link between deficiency in Parkinson’s disease gene and reduced immunoaging

A Parkinson’s disease gene turns out to provide the key to modify diseases related to immunoaging.

18 Jan 2022

Researchers report isolation of potently neutralizing antibodies against highly transmissible SARS-CoV-2 variants

A recent preprint discusses using a combinatorial phage-display library approach to COVIID-19 antibodies.

18 Jan 2022

An alternative mouse model of SARS-CoV-2 infection

Recently, a study has shown the possibility of repurposing hACE2 transgenic mice, primarily raised to study SARS-CoV, to support SARS-CoV-2 infection and pathogenesis.

17 Jan 2022

UC researchers to examine how stress hormones affect cell degeneration in Parkinson's patients

Stress can have a negative effect on anyone's health but presents particular challenges for people with Parkinson's disease.

13 Jan 2022

Metabolic vulnerabilities in malignant cells may lead to new breast cancer therapies

Metabolic differences could explain why some metastatic breast cancer cells rapidly generate tumors after migrating from primary tumors to the brain, while others linger for months or years before forming these secondary tumors, UT Southwestern scientists report in a new study.

12 Jan 2022

MAPK4 may play a key role in triple-negative breast cancer

Scientific evidence supporting the involvement of the enzyme MAPK4 in cancer growth and resistance to certain therapies has been growing quickly.

12 Jan 2022

Manipulating voltage patterns in tumor cells reduces breast cancer metastasis in animal models

In normal cells, electrical voltage patterns provide a blueprint for orderly growth. But with cancer, the opposite happens.

11 Jan 2022

Animal Model News and Research

Combating leukemia cells by disrupting their energy maintenance mechanism

Nitazoxanide shows promise for COVID-19 treatment in animal model

Single-cell sequencing provides detailed insight into early SARS-CoV-2 infection in the lungs

Innate immune specificity is driven by the nervous system, study suggests

Gut microbiome modulation induces behavioral, cognitive changes in Alzheimer's disease model

Researchers develop 3D human spinal cord implants for treating paralyzed patients

Research shows minks mimic severe COVID-19 symptoms, including ARDS

Photobiomodulation may accelerate the healing of skin damage from radiation therapy

Early-stage alveolar epithelial cell necrosis linked to COVID-19-induced acute respiratory distress syndrome

Study suggests synthetic SARS-CoV-2 S glycoprotein coated lipid vesicles are an effective vaccine candidate

Study shows monoclonal antibody and antiviral therapy are useful in preventing the severity of SARS-CoV-2 Omicron infection

Research provides new insights on memory loss in Alzheimer's disease

Study reveals a causal link between deficiency in Parkinson’s disease gene and reduced immunoaging

Study reveals a causal link between deficiency in Parkinson’s disease gene and reduced immunoaging

Researchers report isolation of potently neutralizing antibodies against highly transmissible SARS-CoV-2 variants

An alternative mouse model of SARS-CoV-2 infection

UC researchers to examine how stress hormones affect cell degeneration in Parkinson's patients

Metabolic vulnerabilities in malignant cells may lead to new breast cancer therapies

MAPK4 may play a key role in triple-negative breast cancer

Manipulating voltage patterns in tumor cells reduces breast cancer metastasis in animal models

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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