Cartilage News and Research

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Cartilage is a stiff yet flexible connective tissue found in many areas in the bodies of humans and other animals, including the joints between bones, the rib cage, the ear, the nose, the elbow, the knee, the ankle, the bronchial tubes and the intervertebral discs.

Inner workings of cells probed by new Kleindiek nanomanipulator at UNSW

The mechanism of how cells work is key to understanding how tumours metastasize as well as tissue regeneration and other bodily functions. The process of mechanotransduction, or how a cell converts a physical stimuli into an electrical response is fundamental to these understandings.

From AXT Pty Ltd 30 Oct 2017

Juvenile idiopathic arthritis affects more than 300,000 children in the U.S.

When most people think of arthritis, they picture the knobby knuckles, inflamed joints or aching back of an older person. But more than 300,000 children in the U.S. suffer from chronic juvenile idiopathic arthritis (JIA), which has more to do with joint inflammation than wear and tear on cartilage and bone.

12 Oct 2017

Simple biomechanical test can help analyze tissue implant quality

The quality of the tissue-implant interface is key to the success of implant integration. High-output benchtop screening can help developers in assessing the complex interplay between biomaterials and the body to better prepare for clinical trials, highlights a review in the journal Science and Technology of Advanced Materials.

10 Oct 2017

New insights into rare-among-rare genetic bone disorder

I have been writing about conditions that cause out-of-place bone formation for over 10 years – since the discovery of the gene in 2006 for the rare bone disorder, FOP (fibrodysplasia ossificans progressive). But it was while interviewing geneticist Eileen Shore, PhD last spring about another bone disorder, progressive osseous heteroplasia, or POH, that it really hit me how much more rare POH is compared to FOP.

10 Oct 2017

Researchers test benefit of 'smart' shoe insole for patients with knee osteoarthritis

Osteoarthritis, in the simplest sense, is wear and tear of the cartilage (connecting tissue) of the joints, which results in bones rubbing together, causing pain and stiffness. While other factors, such as genetics, can affect the progression of osteoarthritis, the less strain a person puts on his or her joints, the less likely the cartilage is to deteriorate.

4 Oct 2017

Treating cartilage grafts with bone marrow concentrate before joint replacement speeds recovery

Biologic joint restoration using donor tissue instead of traditional metal and plastic may be an option for active patients with joint defects. Although recovery from a biologic joint repair is typically longer than traditional replacement, successful biologic restoration allows patients to return to full activity. However, in some cases, the transplanted bone does not heal correctly.

25 Sep 2017

UAB researchers detail underlying mechanism leading to age-associated osteoporosis

A major health problem in older people is age-associated osteoporosis -- the thinning of bone and the loss of bone density that increases the risk of fractures. Often this is accompanied by an increase in fat cells in the bone marrow.

22 Sep 2017

Tissue engineering methods could prove useful to create cartilage implants

Different surface topographies and materials provide interesting ways to study cell behaviour and potentially provide novel solutions for treating joint defects. Tissue engineering methods that simulate native cartilage could prove useful to create cartilage implants in the laboratory, according to a doctoral dissertation from Umeå University.

22 Sep 2017

Researcher develops bone marrow models to study hematological and musculoskeletal diseases

For her research on the development of hematological and musculoskeletal disorders, Dr. Cornelia Lee-Thedieck, scientist at Karlsruhe Institute of Technology, is awarded an ERC Starting Grant: The European Research Council decided to fund her project "bloodANDbone" with EUR 1.5 million for five years. At KIT's Institute of Functional Interfaces, Lee-Thedieck develops models of the human bone marrow to study the regeneration of blood and bone by stem cells and how this regeneration is disturbed in diseases like leukemia or bone metastases.

6 Sep 2017

CSHLP releases new book on Tissue Engineering and Regenerative Medicine

Cold Spring Harbor Laboratory Press announced the release of Tissue Engineering and Regenerative Medicine, available on its website in hardcover, paperback, and ebook formats.

6 Sep 2017

NYIT professor awarded multi-year NIH grant for bone-healing research

NYIT has been awarded $442,000 to pursue research into a gene critical in the formation and healing of bones.

5 Sep 2017

Research may lead to first-ever pharmacological treatment for rare genetic bone disease

Scientists at Children's Hospital of Philadelphia report that a drug candidate that blocks abnormal protein signals may lead to the first pharmacologic treatment for hereditary multiple exostoses (HME), a rare pediatric genetic disease.

29 Aug 2017

Traditional Chinese herb may hold key to new osteoporosis therapy for preventing bone loss

An herb widely used in traditional Chinese medicine might hold the key to a new osteoporosis therapy that could prevent bone loss without causing side effects.

29 Aug 2017

Cartilage degeneration algorithm could facilitate clinical decision-making in treatment of osteoarthritis

A novel cartilage degeneration algorithm can predict the progression of osteoarthritis in individual patients, according to new research from the University of Eastern Finland. The new algorithm could greatly facilitate clinical decision-making in the treatment of osteoarthritis.

29 Aug 2017

New review explores evolving treatments and future therapies for osteoarthritis pain

A new review by David A. Walsh and Joanne Stocks in the September 2017 issue of SLAS Discovery (formerly the Journal of Biomolecular Screening) explores evolving treatments and future therapies for osteoarthritis (OA) pain.

26 Aug 2017

Rutgers University leadership creates great strides in breakthrough scientific research

Less than a decade ago, the U.S. Department of Defense established the Armed Forces Institute of Regenerative Medicine I with a multimillion dollar grant to focus research centered on regenerative medicine for the treatment of battlefield injuries and selected Rutgers University-New Brunswick to lead the civilian research program.

26 Aug 2017

Cartilage News and Research

Further Reading

Inner workings of cells probed by new Kleindiek nanomanipulator at UNSW

Juvenile idiopathic arthritis affects more than 300,000 children in the U.S.

Simple biomechanical test can help analyze tissue implant quality

New insights into rare-among-rare genetic bone disorder

Researchers test benefit of 'smart' shoe insole for patients with knee osteoarthritis

Treating cartilage grafts with bone marrow concentrate before joint replacement speeds recovery

UAB researchers detail underlying mechanism leading to age-associated osteoporosis

Tissue engineering methods could prove useful to create cartilage implants

Researcher develops bone marrow models to study hematological and musculoskeletal diseases

CSHLP releases new book on Tissue Engineering and Regenerative Medicine

NYIT professor awarded multi-year NIH grant for bone-healing research

Research may lead to first-ever pharmacological treatment for rare genetic bone disease

Traditional Chinese herb may hold key to new osteoporosis therapy for preventing bone loss

Cartilage degeneration algorithm could facilitate clinical decision-making in treatment of osteoarthritis

New review explores evolving treatments and future therapies for osteoarthritis pain

Rutgers University leadership creates great strides in breakthrough scientific research

Researchers pursuing new approach to treating arthritis

Gravity, mechanical loading play critical role during cartilage development, study shows

Scientists develop new technique for 3D printing of living tissues

Researchers uncover immunological mechanism involved in resolution of inflammations

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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