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Study reveals unique molecular mechanisms of stomach’s acid pump

Nagoya University researchers and colleagues have improved understanding of the molecular mechanisms of a key protein that makes the stomach acidic. Their findings, published in the journal Nature Communications, could lead to better drugs for stomach ulcers and shed light on the functions of similar proteins across the human body.

15 Oct 2021

Study reveals the zoonotic potential of the rat Sialodacryoadenitis virus

A new review aimed to describe the current state of knowledge on Sialodacryoadenitis virus, along with its characteristics and potential zoonotic threat.

13 Oct 2021

New study finds SARS-CoV-2 causes retinal infection

Can coronavirus disease 2019 (COVID-19) affect the eye? New research suggests the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can enter the eye and infect photoreceptor and retinal ganglion cells. In addition, SARS-CoV-2 infection increases the expression of several inflammatory genes, including the cytokine interleukin 33 (IL33), which is linked to COVID-19 disease and retinal degeneration.

13 Oct 2021

New method to diagnose anosmia

In a recent study, researchers discuss a new method of tracking the Nav1.7 channel to reduce the reliance on more invasive diagnostic measures.

13 Oct 2021

Planar cell polarity pathway found to be responsible for the formation and maintenance of synapses

Within the brain and other parts of the nervous system, synapses are key junctional points in between neurons (the nerve cells) where critical signals are transmitted. More specifically, the "glutamatergic" synapses are the prime "excitatory" synapse junctions that neurons use to activate each other and are known to have broad diversity in size and shape.

7 Oct 2021

Researchers develop nanoparticles delivering STING agonists for intravenous cancer immunotherapy

Cancer immunotherapy seeks to turn "cold" tumors into "hot" tumors––those that respond to immunotherapy––by awakening and enlisting the body's own immune system.

30 Sep 2021

SARS-CoV-2 viroporin activity impacts viral infectivity and pathogenicity

A team of researchers studied the two main viroporins of SARS-CoV-2, namely Orf3a and Envelope (E) protein, from a structural viewpoint.

29 Sep 2021

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Oncotarget published "Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells" which reported that to ascertain phenotypical differences between these two distinct culture conditions, these authors carried out a comparative proteomic analysis of a membrane fraction obtained from 3D- and 2D-cultured NSCLC model cell line NCI-H23.

29 Sep 2021

Radiation therapy for ventricular tachycardia may revert heart muscle cells to a younger state

Radiation therapy for ventricular tachycardia — a life-threatening irregular heart rhythm — appears to work by reverting heart muscle cells to a younger state, reducing the irregular rhythms, according to a new study from Washington University School of Medicine in St. Louis.

24 Sep 2021

Scientists characterize new genetic variants that cause nonsyndromic neurodevelopmental disorder

Northwestern Medicine scientists have characterized several variants of the gene GRIK2 that cause nonsyndromic neurodevelopmental disorder (NDD), according to a study published in the American Journal of Human Genetics.

23 Sep 2021

DNA sensor can detect infectious viruses in minutes

A new sensor can detect not only whether a virus is present, but whether it's infectious – an important distinction for containing viral spread.

23 Sep 2021

Engineers optimize nuclear magnetic resonance tools through molecular dynamics simulations

Gadolinium-based contrast agents, the gold standard in magnetic resonance imaging(MRI) to determine the health of a patient, can be improved, according to Rice University engineers who are refining models they first used to enhance oil and gas recovery.

21 Sep 2021

New slow-release system mimics nature to provide long-lasting local anesthesia

Site 1 sodium channel blockers such as tetrodotoxin and saxitoxin are small-molecule drugs with powerful local anesthetic properties.

14 Sep 2021

First pharmacological treatment option for patients with a severe form of epilepsy

Epilepsy comes in a variety of forms. Those affected by a genetically de- termined variety have severe epileptic seizures as early as the first year of life.

1 Sep 2021

Walking can power an implantable stimulator device to speed up tendon healing

Researchers at CÚRAM, the SFI Research Centre for Medical Devices based at NUI Galway, have shown how the simple act of walking can power an implantable stimulator device to speed up treatment of musculoskeletal diseases.

31 Aug 2021

Finding the genetic cause of childhood epilepsy helps improve treatment and care

Epilepsy is one of the most common chronic neurological diseases, affecting more than 50 million people worldwide. Although it is believed that a large proportion of childhood-onset epilepsies are caused by genetic changes, it remains unknown precisely how many of these patients suffer from a genetic disorder and how often the treatment can be targeted to their specific genetic alteration.

31 Aug 2021

Migraine-inducing peptides may protect against diabetes by influencing insulin production

People who get migraines are less likely to develop type 2 diabetes, while some people who develop diabetes become less prone to migraines.

26 Aug 2021

Researchers identify a cluster of small molecules that contribute to coffee's mouthfeel

Coffee drinkers intuitively recognize the pleasure of swallowing a smooth, rich brew versus a watery one.

24 Aug 2021

Study uses computational modeling of coronavirus spike proteins to examine dynamics responsible for immunogenicity and immune escape

A new study published on the bioRxiv* preprint server focused on the development of dynamic computational models for a large subset of S proteins of SARS-CoV, MERS-CoV, and SARS-CoV-2.

23 Aug 2021

New analytical method visualizes cell functions in vasculature-on-a-chip

A microphysiological system (MPS), also known as an organ-on-a-chip, is a 3D organ construct using human cells that help reveal how organs respond to drugs and environmental stimuli.

20 Aug 2021

Ion News and Research

Study reveals unique molecular mechanisms of stomach’s acid pump

Study reveals the zoonotic potential of the rat Sialodacryoadenitis virus

New study finds SARS-CoV-2 causes retinal infection

New method to diagnose anosmia

Planar cell polarity pathway found to be responsible for the formation and maintenance of synapses

Researchers develop nanoparticles delivering STING agonists for intravenous cancer immunotherapy

SARS-CoV-2 viroporin activity impacts viral infectivity and pathogenicity

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Radiation therapy for ventricular tachycardia may revert heart muscle cells to a younger state

Scientists characterize new genetic variants that cause nonsyndromic neurodevelopmental disorder

DNA sensor can detect infectious viruses in minutes

Engineers optimize nuclear magnetic resonance tools through molecular dynamics simulations

New slow-release system mimics nature to provide long-lasting local anesthesia

First pharmacological treatment option for patients with a severe form of epilepsy

Walking can power an implantable stimulator device to speed up tendon healing

Finding the genetic cause of childhood epilepsy helps improve treatment and care

Migraine-inducing peptides may protect against diabetes by influencing insulin production

Researchers identify a cluster of small molecules that contribute to coffee's mouthfeel

Study uses computational modeling of coronavirus spike proteins to examine dynamics responsible for immunogenicity and immune escape

New analytical method visualizes cell functions in vasculature-on-a-chip

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