Mutation News and Research

RSS

Experimental drug shows promise in reducing risk of Alzheimer's-related dementia

An experimental drug appears to reduce the risk of Alzheimer's-related dementia in people destined to develop the disease in their 30s, 40s or 50s, according to the results of a study led by the Knight Family Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU), which is based at Washington University School of Medicine in St. Louis.

19 Mar 2025

Scientists uncover hints of a potential new cause of stomach cancer

For the first time, scientists have systematically analyzed somatic mutations in stomach lining tissue to unpick mutational processes, some of which can lead to cancer.

19 Mar 2025

Study reveals how B cells safeguard high-affinity antibodies

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating in hopes of generating the most effective antibodies.

19 Mar 2025

Research findings solve the paradox of how the immune system balances speed and precision

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted to keep different pathogens in check.

19 Mar 2025

Earliest stages and possible new cause of stomach cancer revealed

For the first time, scientists have systematically analyzed somatic mutations in stomach lining tissue to unpick mutational processes, some of which can lead to cancer.

19 Mar 2025

Researchers challenge the genetic paradigm of cancer

It's time for researchers to reconsider the current paradigm of cancer as a genetic disease, argued Sui Huang from the Institute for Systems Biology, USA, and colleagues in a new essay published March 18th in the open-access journal PLOS Biology.

19 Mar 2025

Testing a novel approach to restore normal heart function in Myotonic Dystrophy Type 1

Myotonic Dystrophy Type 1 (DM1) is the most common adult-onset form of muscular dystrophy and a condition that severely affects multiple organs including skeletal muscle, heart, brain and the gastrointestinal tract.

18 Mar 2025

New discovery unravels mystery behind overactive immune responses

Autoimmune diseases, which are estimated to affect more than 15 million people in the U.S., occur when the body responds to immune-system false alarms, and infection-fighting first responders are sent out to attack threats that aren't there.

18 Mar 2025

ASCOLT trial explores aspirin’s role in preventing colorectal cancer recurrence

A large-scale, international, multicentre, phase 3 clinical trial of aspirin for the secondary prevention of colorectal cancer has concluded.

17 Mar 2025

Congenital heart defects may be linked to increased cancer risk in babies and mothers

Being born with a heart defect may be associated with an increased cancer risk for babies and their moms, according to new research published today in the American Heart Association's flagship journal Circulation.

17 Mar 2025

Breakthrough peptide inhibitor effective against multiple SARS-CoV-2 variants

SARS-CoV-2, the virus responsible for COVID-19, infects cells by binding its spike protein to angiotensin-converting enzyme 2 (ACE2) receptors.

14 Mar 2025

Combination of RAS inhibition and immunotherapy provides breakthrough for pancreatic cancer

Adding immunotherapy to a new type of inhibitor that targets multiple forms of the cancer-causing gene mutation KRAS kept pancreatic cancer at bay in preclinical models for significantly longer than the same targeted therapy by itself, according to researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine's Abramson Cancer Center.

14 Mar 2025

WEHI team makes major strides in the fight against Parkinson's disease

WEHI researchers have made a huge leap forward in the fight against Parkinson's disease, solving a decades-long mystery that paves the way for development of new drugs to treat the condition.

14 Mar 2025

Already approved drug avapritinib shows promise in treating high-grade gliomas

High-grade glioma, an aggressive form of pediatric and adult brain cancer, is challenging to treat given the tumor location, incidence of recurrence and difficulty for drugs to cross the blood-brain barrier.

13 Mar 2025

Updates on influenza vaccine strain recommended by WHO (2025-2026 northern hemisphere)

To maintain vaccine efficacy, WHO regularly updates influenza vaccine strains based on global epidemiological, virological, and serological analyses.

From Sino Biological Inc. 12 Mar 2025

Regulating cell acidity could transform autoimmune disease treatments

What if treating autoimmune diseases was as simple as regulating the acidity levels of parts of patients' cells? Genetic screening may have unlocked a path for treating the severe inflammation associated with many immune diseases by regulating one protein's role in helping another protein control cell acidity, according to new research published in Cell by a team from the Perelman School of Medicine at the University of Pennsylvania.

11 Mar 2025

Study investigates genetic mutations linked to occupational exposures

Occupational and environmental exposures can put specific groups of people at higher risk of cancer, including firefighters. A new study by investigators at Mass General Brigham examines a cancer rarely studied in firefighters: gliomas-a type of tumor that forms in the brain or spinal cord.

11 Mar 2025

Ovarian cancer mutations across populations show similarities and unique differences

An extensive tumor genomic analysis of individuals with ovarian cancer, led by researchers from Huntsman Cancer Institute at the University of Utah (the U) and Emory University, revealed that Black women have nearly identical mutations to other previously studied populations.

10 Mar 2025

Breakthrough drug combination targets KRAS mutation in lung cancer

A breakthrough in lung cancer treatment may be on the horizon. Scientists at VCU Massey Comprehensive Cancer Center have uncovered a powerful combination therapy leveraging sotorasib-an FDA-approved drug in the market-and an experimental drug called FGTI-2734, which could make precision medicine more effective for patients with a highly resistant form of lung cancer.

10 Mar 2025

Research poses a new explanation for how cancer-fighting drugs attack and destroy tumor cells

Research by UMass Chan Medical School scientists Sharon Cantor, PhD, and Jenna M. Whalen, PhD, poses a new explanation for how cancer-fighting drugs attack and destroy BRCA1 and BRCA2 tumor cells.

7 Mar 2025

Mutation News and Research

Experimental drug shows promise in reducing risk of Alzheimer's-related dementia

Scientists uncover hints of a potential new cause of stomach cancer

Study reveals how B cells safeguard high-affinity antibodies

Research findings solve the paradox of how the immune system balances speed and precision

Earliest stages and possible new cause of stomach cancer revealed

Researchers challenge the genetic paradigm of cancer

Testing a novel approach to restore normal heart function in Myotonic Dystrophy Type 1

New discovery unravels mystery behind overactive immune responses

ASCOLT trial explores aspirin’s role in preventing colorectal cancer recurrence

Congenital heart defects may be linked to increased cancer risk in babies and mothers

Breakthrough peptide inhibitor effective against multiple SARS-CoV-2 variants

Combination of RAS inhibition and immunotherapy provides breakthrough for pancreatic cancer

WEHI team makes major strides in the fight against Parkinson's disease

Already approved drug avapritinib shows promise in treating high-grade gliomas

Updates on influenza vaccine strain recommended by WHO (2025-2026 northern hemisphere)

Regulating cell acidity could transform autoimmune disease treatments

Study investigates genetic mutations linked to occupational exposures

Ovarian cancer mutations across populations show similarities and unique differences

Breakthrough drug combination targets KRAS mutation in lung cancer

Research poses a new explanation for how cancer-fighting drugs attack and destroy tumor cells

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

Latest News