Proteomics News and Research

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The term 'proteome' was first coined in 1994, and refers to all the proteins in a cell, tissue, or organism. Proteomics refers to the study of the proteome. Because proteins are involved in almost all biological activities, the proteome is a rich source of biological information.

Why is it Important to Democratize Proteomics Data?

In this interview, we speak to Steve Kosteski from IsoPlexis about the importance of single-cell proteomics within the life sciences sector.

From Society for Laboratory Automation and Screening (SLAS) 23 Feb 2022

Novel approach pinpoints genetic variants involved in congenital heart disease

Nearly 1 percent of all children are born with congenital heart disease - a range of potentially life-threatening problems with the structure and function of their hearts. For most children, the precise causes of these frightening defects are unknown.

18 Feb 2022

Role of quantitative, multiplexed, targeted proteomics in determining variant-specific SARS-CoV-2 antibody response

Researchers developed a ‘bait and capture’ system which was further followed by a multiplexed and targeted proteomic liquid chromatography-tandem mass spectrometry analyses for the comparison of immune correlates in response to vaccination, natural infection, as well as protection against SARS-CoV-2 variants.

18 Feb 2022

New METPlatform allows researchers to test drugs for possible use in brain metastases

It is estimated that about a quarter of cancer patients are at risk of brain metastases, a rate that is increasing especially among those who suffer relapses after having undergone different cancer treatments.

17 Feb 2022

Hundreds of new proteins that could play a role in cystic fibrosis discovered

Researchers at the University of Toronto have identified hundreds of new proteins that could play a role in cystic fibrosis, and which may shed light on why some patients respond better than others to current therapies.

14 Feb 2022

Researchers identify autoantibody targets in COVID-19 patients

In a new study, researchers have been investigating auto-immune responses to natural human antigens in COVID-19 patients.

14 Feb 2022

First unbiased proteome scale study expands the number of known transcriptional activators

Also known as transcriptional activators for their ability to induce transcription of genes into RNA messages, these proteins are essential for the cells to function properly. Yet little is known about these proteins, and it wasn't clear how many activators there might be in human cells – until now.

11 Feb 2022

New method decodes the role of DDX41 protein in preventing double-strand breaks in DNA

There are many different ways in which the genetic material DNA can be damaged, resulting in the development of diseases such as cancer. Certain forms of DNA damage are associated with so-called R-loops.

8 Feb 2022

New cloud-based data resource helps researchers to identify subtypes of ALS

A new cloud-based data resource co-developed by scientists at Cedars-Sinai provides the research community with a comprehensive set of tools to help identify new subtypes of amyotrophic lateral sclerosis (ALS), a fatal neurological disorder.

4 Feb 2022

Three different autism risk genes found to have similar effects on brain development

Autism spectrum disorder has been associated with hundreds of different genes, but how these distinct genetic mutations converge on a similar pathology in patients has remained a mystery.

2 Feb 2022

Study uncovers a class of microbial enzymes that drive ulcerative colitis

Ulcerative colitis, a subtype of inflammatory bowel disease, is a chronic ailment of the colon affecting nearly one million individuals in the United States. It is thought to be linked to disruptions in the gut microbiome - the bacteria and other microbes that live inside us - but no existing treatments actually target these microorganisms.

2 Feb 2022

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

The Damon Runyon Cancer Research Foundation has announced its newest cohort of Damon Runyon Fellows, 13 outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

29 Jan 2022

Structural proteomics approaches can help in the treatment of neurodegenerative diseases

Two researchers from Skoltech and McGill University have published a review of the promising research field known as structural proteomics in the influential journal Chemical Reviews.

27 Jan 2022

Blood proteoforms may help predict liver transplant rejection

Northwestern University scientists have discovered families of proteins in the body that could potentially predict which patients may reject a new organ transplant, helping inform decisions about care.

27 Jan 2022

Endosomal sorting of neuropilin-1 in SARS-CoV-2 infectivity

A study recently identified Neurolipin-1 or NRP1, a host factor for SARS-CoV-2 infection, as a cargo retrograde-transported by the ESCPE-1.

26 Jan 2022

The Role of Glycans in the Cell and Glycans Imaging Method

In this interview, News-Medical talks to a pioneer of glycan imaging, Richard Drake about glycans, their role in maintaining cellular homeostasis, glycopeptide analysis, and method development for glycan imaging.

From Bruker Daltonics 26 Jan 2022

Researchers find ELF5 gene a leading candidate behind severe COVID-19

Are there any risk factors that predispose patients to severe COVID-19 outcomes? A recent study published in the medRxiv* preprint server sheds light on this popular question. Using a combination of population genetics to single-cell RNA sequencing, European researchers identified the respiratory epithelial cell-specific ELF5 gene as a potential mediator for severe COVID-19 cases.

24 Jan 2022

Researchers uncover new findings about the role of tau in neurodegenerative disease

Utilizing cutting-edge proteomics, researchers at the Buck Institute and elsewhere have mapped the "tau interactome" uncovering new findings about the role of tau in neurodegenerative disease. Publishing in Cell, scientists found that mutant tau impacts the function of mitochondria in human neurons.

20 Jan 2022

Machine learning model uses blood plasma proteins to predict survival for COVID-19 patients

A single blood sample from a critically ill COVID-19 patient can be analyzed by a machine learning model which uses blood plasma proteins to predict survival, weeks before the outcome, according to a new study published this week in the open-access journal PLOS Digital Health by Florian Kurth and Markus Ralser of the Charité – Universitätsmedizin Berlin, Germany, and colleagues.

19 Jan 2022

Paradigm4 joins the Tetra Partner Network to leverage Tetra Data into high-performing analytical computing applications for pharmaceutical customers

TetraScience, the R&D Data Cloud company, announced today that Paradigm4, an integrated scientific data analytics company, has joined the Tetra Partner Network so that pharmaceutical customers can accelerate research decision-making using Tetra Data as a foundation for analytical computing.

From TetraScience, Inc. 18 Jan 2022

Proteomics News and Research

Further Reading

Why is it Important to Democratize Proteomics Data?

Novel approach pinpoints genetic variants involved in congenital heart disease

Role of quantitative, multiplexed, targeted proteomics in determining variant-specific SARS-CoV-2 antibody response

New METPlatform allows researchers to test drugs for possible use in brain metastases

Hundreds of new proteins that could play a role in cystic fibrosis discovered

Researchers identify autoantibody targets in COVID-19 patients

First unbiased proteome scale study expands the number of known transcriptional activators

New method decodes the role of DDX41 protein in preventing double-strand breaks in DNA

New cloud-based data resource helps researchers to identify subtypes of ALS

Three different autism risk genes found to have similar effects on brain development

Study uncovers a class of microbial enzymes that drive ulcerative colitis

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

Structural proteomics approaches can help in the treatment of neurodegenerative diseases

Blood proteoforms may help predict liver transplant rejection

Endosomal sorting of neuropilin-1 in SARS-CoV-2 infectivity

The Role of Glycans in the Cell and Glycans Imaging Method

Researchers find ELF5 gene a leading candidate behind severe COVID-19

Researchers uncover new findings about the role of tau in neurodegenerative disease

Machine learning model uses blood plasma proteins to predict survival for COVID-19 patients

Paradigm4 joins the Tetra Partner Network to leverage Tetra Data into high-performing analytical computing applications for pharmaceutical customers

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