Efficacy News and Research

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Novel nanocapsules offer solution for improving the efficacy of chemodynamic oncotherapy

In a paper published on Small recently, a collaborated research team led by Prof. WANG Hui from High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences reported the synthesis of hollow cuprous carbon (HCONC) by one-step hydrothermal method as well as their applications in efficient chemodynamic therapy.

14 Mar 2022

Study evaluates efficacy of isotretinoin in improving COVID-19 outcomes

Researchers evaluated the effectiveness of isotretinoin (13-cis retinoic acid) in improving COVID-19 outcomes.

14 Mar 2022

Protection against SARS-CoV-2 Omicron variant by hetero-bivalent nanobodies

A new study investigated the broad-spectrum protection provided by hetero-bivalent nanobodies against SARS-CoV-2 variants of concern, such as Omicron.

14 Mar 2022

Current evidence that vitamin D is effective against COVID-19 neurological sequelae

Researchers analyze the available scientific evidence supporting vitamin D as a neuroprotective agent against the neurological sequelae of COVID-19.

14 Mar 2022

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Researchers demonstrate enhanced loss-of-function editing of CRISPR/Cas9 in human cells.

14 Mar 2022

In silico screening of natural ACE2 inhibitors

Researchers identify potential ACE2 inhibitors through a virtual screening protocol.

14 Mar 2022

Neutralizing activity of therapeutic antibodies against clinical strains of BA.1 and BA.2 sub-lineages of the Omicron variant

Researchers conducted an in vitro analysis to assess the efficacy of monoclonal antibodies against the SARS-CoV-2 Omicron BA.2 and BA.1 variants.

14 Mar 2022

The impact of PLEX on the survival of patients with severe COVID-19 and the effect on the cytokine release syndrome

Researchers evaluated the survival benefit conferred by PLEX in patients with severe COVID-19 and cytokine-storm syndrome.

14 Mar 2022

New approach to send ‘friendly’ nano-particles into the body shows promising results

A new approach to send ‘friendly’ nano-particles into a patient’s blood stream has shown promising results by modifying the surface of these potential drug, vaccine or cancer treatment delivery objects to encourage the best result.

14 Mar 2022

Tumor cells’ 'ferroaddiction' can be exploited to deliver powerful anticancer drugs

Researchers at the University of California, San Francisco, have discovered that cells carrying the most common mutation found in human cancer accumulate large amounts of ferrous iron and that this "ferroaddiction" can be exploited to specifically deliver powerful anticancer drugs without harming normal, healthy cells.

11 Mar 2022

Canadian scientist discusses about how society could better prepare for future pandemics

Aled Edwards is of two minds about medicine's response to COVID-19. On one hand, he notes, we had life-saving vaccines and therapies less than a year after the discovery of SARS-CoV-2. On the other, more than six million, and possibly as many as 18 million people have died, and global access to advances that can prevent and treat severe disease remains highly inequitable.

11 Mar 2022

Lower, more frequent doses of nanomedicines may provide additional benefits for cancer patients

Tiny structures called nanoparticles can be used to carry substances to certain parts of the body - for example, to deliver a chemotherapy drug to a tumor.

11 Mar 2022

Meta-analysis finds intensified anticoagulation had no effect on short term mortality among hospitalized COVID-19 patients

A recent systematic review and meta-analysis evaluated the safety and efficacy of intensified anticoagulation therapy in COVID-19 patients.

11 Mar 2022

Updated results from ongoing study on the effect of a BNT162b2 booster dose on anti-SARS-CoV-2 antibodies

Researchers assessed the increase in Pfizer/BioNTech BNT162b2 vaccine efficacy on administering a homologous booster dose.

11 Mar 2022

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Researchers evaluated the efficacy of viral spike domain 2-specific human monoclonal antibodies delivered intranasally, against all beta coronaviruses in hamsters and mice.

11 Mar 2022

Aminoglycoside antibiotic geneticin shows selective antiviral effect against SARS-CoV-2

Researchers elucidated antiviral activities of aminoglycoside geneticin against seven SARS-CoV-2 variants using different cell lines and respiratory tissues.

11 Mar 2022

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Researchers discovered and optimized cysteine-reactive pyrazoline-based covalent inhibitors for several coronaviruses' Mpro, including SARS-CoV-2.

11 Mar 2022

Cellular therapy offers promise for patients with Duchenne muscular dystrophy, trial shows

A clinical trial at UC Davis Health and six other sites showed that a cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy (DMD), a rare genetic disorder causing muscle loss and physical impairments in young people.

10 Mar 2022

Using metal oxide nanoparticles as 'radiosensitizers' for gentler cancer treatment

Radiation therapy is one of the cornerstones of cancer therapy. However, some types of tumor respond little or hardly at all to radiation. If it were possible to make tumor cells more sensitive, treatment would be more effective and gentler.

10 Mar 2022

Study examines the safety, efficacy of old 'forgotten' antibiotic for treating resistant bacterial infections

The results make it possible to expand the treatment options for infections for which few alternatives exist, while at the same time helping to avoid increasing resistance to the usual drugs.

10 Mar 2022

Efficacy News and Research

Novel nanocapsules offer solution for improving the efficacy of chemodynamic oncotherapy

Study evaluates efficacy of isotretinoin in improving COVID-19 outcomes

Protection against SARS-CoV-2 Omicron variant by hetero-bivalent nanobodies

Current evidence that vitamin D is effective against COVID-19 neurological sequelae

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

In silico screening of natural ACE2 inhibitors

Neutralizing activity of therapeutic antibodies against clinical strains of BA.1 and BA.2 sub-lineages of the Omicron variant

The impact of PLEX on the survival of patients with severe COVID-19 and the effect on the cytokine release syndrome

New approach to send ‘friendly’ nano-particles into the body shows promising results

Tumor cells’ 'ferroaddiction' can be exploited to deliver powerful anticancer drugs

Canadian scientist discusses about how society could better prepare for future pandemics

Lower, more frequent doses of nanomedicines may provide additional benefits for cancer patients

Meta-analysis finds intensified anticoagulation had no effect on short term mortality among hospitalized COVID-19 patients

Updated results from ongoing study on the effect of a BNT162b2 booster dose on anti-SARS-CoV-2 antibodies

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Aminoglycoside antibiotic geneticin shows selective antiviral effect against SARS-CoV-2

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Cellular therapy offers promise for patients with Duchenne muscular dystrophy, trial shows

Using metal oxide nanoparticles as 'radiosensitizers' for gentler cancer treatment

Study examines the safety, efficacy of old 'forgotten' antibiotic for treating resistant bacterial infections

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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