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Elevated hormone flags liver disease in mice with serious genomic disorder

Researchers have discovered that a hormone, fibroblast growth factor 21 (FGF21), is extremely elevated in mice with liver disease that mimics the same condition in patients with methylmalonic acidemia (MMA), a serious genomic disorder.

6 Dec 2018

Scientists reveal how DNA damage leads to cancer and hereditary diseases

Scientists revealed how DNA damage influences mutations. Turned out that its contribution to mutagenesis was underestimated and many of the inheritance mutations are caused not by errors in DNA doubling, but by damage to this fragile molecule.

5 Dec 2018

Researcher discovers key differences in protein production between healthy cells and tumors

The human body is made up of more than 200 types of cell, from bone and brain to liver and lung. Each cell type is determined by the particular combination of proteins it produces.

4 Dec 2018

Researchers find two connective tissue cells to be linked to worse prognosis of breast cancer

In certain forms of cancer, connective tissue forms around and within the tumor. One previously unproven theory is that there are several different types of connective tissue cells with different functions, which affect the development of the tumor in different ways.

4 Dec 2018

Study examines whether taking multiple medications for heart failure can limit abilities in older adults

As we age, we tend to develop a number of chronic health conditions and concerns. Often, managing health problems can mean that older adults may take many different medications. When older adults take five or more medicines (a scenario health experts call "polypharmacy", it can increase the risk of harmful side effects.

3 Dec 2018

Genetic relic of the 'Black Death' may provide clues for treating fatal liver scarring

A gene mutation that is believed to have safeguarded some people in 14th century Europe from the bubonic plague today may be protecting HIV patients co-infected with hepatitis C from potentially fatal liver scarring, says a University of Cincinnati College of Medicine physician-scientist.

3 Dec 2018

Using nanocarrier-delivered microRNA to target sepsis

One in three patients who die in the U.S. dies of sepsis, according to the Centers for Disease Control and Prevention. It is one of the leading causes of death in intensive care units and, with an estimated price tag of $20 billion in 2011, the most expensive condition that hospitals treat.

3 Dec 2018

IU scientists find toxic flame retardants in children's car seats

In a new study, Indiana University scientists found toxic flame retardants in newly manufactured children's car seats, sparking concerns about children's health. Of the 18 children's car seats tested, 15 contained new or traditional hazardous flame retardant chemicals.

3 Dec 2018

Liver immune cells contain inert HIV and are unlikely to reproduce infection, study reveals

In a proof-of-principle study, researchers at Johns Hopkins revealed that certain immune system cells found in the human liver, called liver macrophages, contain only inert HIV and aren't likely to reproduce infection on their own in HIV-infected people on long-term antiretroviral therapy.

30 Nov 2018

FDA approves new drug for treatment of rare autoimmune disorder

The U.S. Food and Drug Administration today approved Firdapse (amifampridine) tablets for the treatment of Lambert-Eaton myasthenic syndrome (LEMS) in adults.

29 Nov 2018

Researchers discover pathway for enhancing the self-repair efforts of injured kidneys

A team of researchers led by Jonathan Stamler, MD, of Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, has discovered a pathway for enhancing the self-repair efforts of injured kidneys.

29 Nov 2018

First biosimilar approved by FDA for treatment of adult patients with non-Hodgkin’s lymphoma

The U.S. Food and Drug Administration today approved Truxima (rituximab-abbs) as the first biosimilar to Rituxan (rituximab) for the treatment of adult patients with CD20-positive, B-cell non-Hodgkin's lymphoma (NHL) to be used as a single agent or in combination with chemotherapy.

29 Nov 2018

Lifestyle intervention can benefit obese children despite common gene variants

Children who are genetically predisposed to overweight, due to common gene variants, can still lose weight by changing their diet and exercise habits.

29 Nov 2018

New method could improve outcome of leukemia patients receiving stem-cell transplants

Stem-cell transplantation is an effective form of therapy to fight leukemia. In many cases, however, the transferred immune cells of the donor also attack the recipients' healthy tissue - often with fatal consequences.

28 Nov 2018

Researchers map cells in the early human placenta to shed light on pregnancy complications

To treat and prevent pregnancy-related disorders, researchers must understand not only what can go wrong, but when. Complications, such as preeclampsia and pre-term birth, often occur in the second or third trimester, and most research to date has focused on those later stages of pregnancy. But the biological events that lead to these problems could start much earlier.

28 Nov 2018

Research reveals how a small molecule helps remove excess cholesterol

Scientists have determined the structure of the activated form of an enzyme that helps to return excess cholesterol to the liver, a study in eLife reports.

27 Nov 2018

Higher rates of alcohol use found among Hispanic Americans who are more 'Americanized'

Higher rates of alcohol use and drinking consequences are found among Hispanic American adolescents and adults who are more "Americanized," according to a new study authored by Southern Methodist University professor Priscilla Lui and her colleague, Byron Zamboanga, at Smith College.

27 Nov 2018

Using Pre-Clinical Imaging to Detect Cancer

In this interview, Émilie Beaulieu Ouellet, Application Scientist for life science imaging at Photon Etc talks to New-Medical about their range of preclinical infrared imagers and how they can allow cancer detection.

From Photon etc. 27 Nov 2018

Study: Intermittent fasting not superior to conventional calorie restriction diets

Intermittent fasting helps lose weight and promotes health. However, it is not superior to conventional calorie restriction diets, scientists from the German Cancer Research Center and Heidelberg University Hospital have found out in a study called HELENA - the largest investigation on intermittent fasting to date.

27 Nov 2018

Researchers find link between inflammatory markers and tumor aggressiveness

Researchers at University Putra Malaysia found a relationship between some markers of inflammation in the body and the aggressiveness of certain malignant tumors.

27 Nov 2018

Liver News and Research

Elevated hormone flags liver disease in mice with serious genomic disorder

Scientists reveal how DNA damage leads to cancer and hereditary diseases

Researcher discovers key differences in protein production between healthy cells and tumors

Researchers find two connective tissue cells to be linked to worse prognosis of breast cancer

Study examines whether taking multiple medications for heart failure can limit abilities in older adults

Genetic relic of the 'Black Death' may provide clues for treating fatal liver scarring

Using nanocarrier-delivered microRNA to target sepsis

IU scientists find toxic flame retardants in children's car seats

Liver immune cells contain inert HIV and are unlikely to reproduce infection, study reveals

FDA approves new drug for treatment of rare autoimmune disorder

Researchers discover pathway for enhancing the self-repair efforts of injured kidneys

First biosimilar approved by FDA for treatment of adult patients with non-Hodgkin’s lymphoma

Lifestyle intervention can benefit obese children despite common gene variants

New method could improve outcome of leukemia patients receiving stem-cell transplants

Researchers map cells in the early human placenta to shed light on pregnancy complications

Research reveals how a small molecule helps remove excess cholesterol

Higher rates of alcohol use found among Hispanic Americans who are more 'Americanized'

Using Pre-Clinical Imaging to Detect Cancer

Study: Intermittent fasting not superior to conventional calorie restriction diets

Researchers find link between inflammatory markers and tumor aggressiveness

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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