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Multifunctional nanoparticle platforms for targeting and imaging cancer cells

There has been much recent interest in how nanotechnology will impact the field of medicine. Unfortunately, a number of promising nanostructured systems have turned out to be extremely toxic to humans, thus precluding their use in clinical applications and dashing hopes of an early success for the interdisciplinary field of nanobiotechnology.

21 Jun 2007

More effective treatment for malaria control during pregnancy in Africa

A review of previous studies indicates that two doses of a malaria preventive therapy during pregnancy provides substantial benefit to HIV-negative women in Africa, with more frequent dosing apparently necessary for HIV-positive women, according to an article in the June 20 issue of JAMA.

20 Jun 2007

New molecular mechanism discovered that may 'spontaneously' cause liver cancer

Adding more good news to last week's announcement that Nexavar (sorafenib) may be the first effective treatment for advanced liver cancer, researchers at the Lombardi Comprehensive Cancer Center at Georgetown University have uncovered a new molecular mechanism that may 'spontaneously' cause liver cancer.

20 Jun 2007

Researchers identify potential role for retinoic acid in autoimmune and inflammatory diseases

An important finding, which could eventually lead to a new therapeutic approach for treating autoimmune and inflammatory diseases such as rheumatoid arthritis, colitis, psoriasis and others, was announced by researchers at the La Jolla Institute for Allergy & Immunology (LIAI).

17 Jun 2007

Breakdown of myelin may be the cause of Huntington's disease

Last month, Dr. George Bartzokis, director of the UCLA Memory Disorders and Alzheimer's Disease Clinic, suggested in the journal Alzheimer's & Dementia that the breakdown of a type of myelin that develops late in life promotes the buildup of toxic amyloid plaques long associated with Alzheimer's disease.

16 Jun 2007

In vivo imaging of siRNA delivery and silencing in tumors

Using magnetic nanoparticles labeled with dye molecules, a team of investigators at the Massachusetts General Hospital has developed a delivery vehicle capable of transporting antitumor small interfering RNA (siRNA) molecules into cells.

14 Jun 2007

Nanoparticle-enabled peptide delivery triggers tumor regression

Cells possess a variety of ways of dealing with mutations that can cause them to grow uncontrollably and eventually form a tumor. The tumor suppressor gene p53 plays a critical role in these cancer prevention processes, largely by triggering a form a cell death known as apoptosis.

14 Jun 2007

Nanoprobes with near-infrared persistent luminescence for in vivo imaging

In a new take on use of luminescent nanoparticles as cancer imaging probes, a team of investigators from several research institutes in Paris, France, has developed new metal-containing nanoparticles that emit light for several hours after they are initially excited.

14 Jun 2007

Researchers create first 3-D optical images of human breast cancer in patients based on tissue fluorescence

Fluorescence diffuse optical tomography, or FDOT, relies on the presence of fluorophore molecules in tissue that re-radiate fluorescent light after illumination by excitation light of a different color.

14 Jun 2007

Myelin and Huntington's disease

14 Jun 2007

New contributor to aggressive cancers

Mutations in the cell adhesion molecule known as integrin alpha 7 (integrin 7) lead to unchecked tumor cell proliferation and a significantly higher incidence in cancer spread, or metastasis, in several cancer cell lines, report researchers at the University of Pittsburgh School of Medicine in a study published in the Journal of the National Cancer Institute.

8 Jun 2007

Researchers observe brain cell development in real time

For the first time anywhere, a researcher at the Hebrew University of Jerusalem has succeeded in observing in vivo the generation of neurons in the brain of a mammal.

28 May 2007

Discovery of fungi that uses radioactivity as an energy source

Scientists have long assumed that fungi exist mainly to decompose matter into chemicals that other organisms can then use.

24 May 2007

Targeted nanoparticles offer promising techniques for cancer treatment

Researchers in the laboratory of Mark E. Davis at the California Institute of Technology have been using small interfering RNA (siRNA), sometimes known as silencing RNA, to "silence" specific genes that are implicated in certain malignancies.

22 May 2007

Nanomedicine opens the way for nerve cell regeneration

The ability to regenerate nerve cells in the body could reduce the effects of trauma and disease in a dramatic way.

22 May 2007

Nanocomposite labeled cancer cells can be targeted and destroyed using lasers

A nanocomposite particle can be constructed so that it has a mix of properties that would not otherwise happen in nature.

22 May 2007

Glucose plays a key role in enabling healthy beta cells

A key aspect of how embryos create the cells which secrete insulin is revealed in a new study published in the Journal of Biological Chemistry.

18 May 2007

Danube Pharmaceuticals starts trial of DNB-001 in patients with ocular hypertension

Danube Pharmaceuticals, Inc. has announced the initiation of a multi-center, randomized, double-blind, placebo controlled Phase II study with DNB-001 in 60 patients with ocular hypertension (elevated intraocular pressure).

18 May 2007

Biomoda files for patent protection for porphyrin molecule

Biomoda, Inc. is expanding its patent portfolio with an additional patent pending for the use of its patented porphyrin molecule as part of a sophisticated cancer drug delivery system.

18 May 2007

Antibody-based therapies effective at controlling malaria

Passive immunization through the development of fully human antibodies specific to Plasmodium falciparum may be effective at controlling the disease, report researchers led by Dr. Richard S.

18 May 2007