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Culture techniques can significantly affect cell growth and function

When it comes to growing cells in a lab, technique matters. A new Brown University study shows that nerve cells grown in three-dimensional cultures use 1,766 genes differently compared to nerve cells grown in standard two-dimensional petri dishes.

17 May 2007

Health effects of polyphenols

Polyphenols, dietary substances from vegetables, fruits and green tea, bring about a change in the energy metabolism.

15 May 2007

Researchers design cell culture test for assessing a compound's genetic toxicity - cheaper than animal tests

In the daunting marathon that leads to successful drugs, promising drug candidates must pass toxicity tests before entering clinical trials.

15 May 2007

Breakthrough on cytomegalovirus transmission

Researchers at the La Jolla Institute for Allergy & Immunology have shown that cytomegalovirus (CMV) in the salivary glands can be reduced , and in some cases eliminated , through the use of antibodies to enhance the disease-fighting power of the immune system.

11 May 2007

Insulin therapy shown to treat early experimental diabetic retinopathy

Researchers presented study results that indicate that subconjunctivally delivered insulin ameliorates degenerative and inflammatory responses in diabetic rat retinas.

11 May 2007

Cell-derived scaffold reproduction of cartilage tissue

A new study examines the use of tissue-engineered scaffolding made of cartilage cells, which have a limited ability to heal naturally, to replace defective cartilage tissue.

10 May 2007

Plant chemical harmine fights diabetes in mice

After screening hundreds of compounds for their effects on fat development, researchers have discovered that an ingredient found in some plants fights diabetes in mice without some of the side effects attributed to other antidiabetes drugs.

9 May 2007

Little-known cell networks vital to circadian rhythm

Circadian rhythm is the basic 24-hour cycle that involves various behaviors, including sleeping and eating, in all living organisms.

4 May 2007

Cancer Research Technology licenses therapeutic antibodies to Peptech

Cancer Research Technology Limited (CRT), the oncology-focused development and commercialisation company, today announces it has licensed rights to a panel of cancer therapeutic antibodies to Peptech Limited.

2 May 2007

Caution against over-aggressive use of erythropoiesis-stimulating agents for cancer-related anemia

Echoing recent FDA warnings, a research group from Northern Ireland cautions against over-aggressive use of a group of drugs called "erythropoiesis-stimulating agents" (ESAs) to treat anemia in some cancer patients, according to a commentary in the April issue of The Oncologist, published by AlphaMed Press.

1 May 2007

Unicellular microRNA discovery

In the May 15th issue of Genes & Development, an international collaboration of researchers, led by Dr. Yijun Qi (National Institute of Biological Sciences, China), report on their discovery of microRNAs in the unicellular green alga, Chlamydomonas reinhardtii.

30 Apr 2007

New system for restoring damaged or lost knee cartilage tissue

Knee osteoarthritis affects 30 million people worldwide, causing pain and joint stiffness and in severe cases restricted mobility.

24 Apr 2007

Viventia Biotech announces results of Proxinium antibody in combinaton with chemotherapy and radiation

Viventia Biotech has announced results of in vitro cytotoxicity and in vivo pharmacokinetic studies conducted to evaluate the potential for combining its phase III anti-cancer antibody therapeutic, Proxinium, with first-line standard of care therapy for squamous cell carcinoma of the head & neck (SCCHN).

19 Apr 2007

Lexicon-Genentech reveals potential therapeutic targets

Lexicon Genetics Incorporated has announced that data was presented highlighting potential therapeutic targets related to its collaboration with Genentech, Inc. at the Society for Biomolecular Sciences 13th Annual Conference & Exhibition in Montreal, Canada.

19 Apr 2007

Oncolytics Biotech researchers demonstrate reovirus/gemcitabine

Oncolytics Biotech announced that a poster by Dr. Maureen E. Lane et al. of Cornell University, New York , entitled "In Vivo Synergy between Oncolytic Reovirus and Gemcitabine in Ras-Mutated Human HCT116 Xenografts" was presented at the American Association for Cancer Research (AACR) Annual Meeting in Los Angeles, CA.

18 Apr 2007