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Surgery to correct congenital heart disease linked to increased risk of adult hypertension

In a medical records study covering thousands of children, a U.S.-Canadian team led by researchers at Johns Hopkins Medicine concludes that while surgery to correct congenital heart disease (CHD) within 10 years after birth may restore young hearts to healthy function, it also may be associated with an increased risk of hypertension -- high blood pressure -- within a few months or years after surgery.

8 Apr 2021

Novel diarylamides show promise as orally active diuretics to treat hyponatremia

Urea transporters (UT) play a vital role in the mechanism of urine concentration and are recognized as novel targets for the development of salt-sparing diuretics. Thus, UT inhibitors are promising for development as novel diuretics.

8 Apr 2021

Research offers an efficient approach to mine the chemical diversity of endophytic fungi

Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus Penicillium dangeardii revealed 43 biosynthetic gene clusters, exhibited its strong ability to produce numbers of secondary metabolites.

8 Apr 2021

Full assembly of human chromosome 8 reveals novel genes, disease risks

The full assembly of human chromosome 8 is reported this week in Nature. While on the outside this chromosome looks typical, being neither short nor long or distinctive, its DNA content and arrangement are of interest in primate and human evolution, in several immune and developmental disorders, and in chromosome sequencing structure and function generally.

8 Apr 2021

Real-time imaging shines light on the coordination of neural stem cell activation

In all adult vertebrates, neural stem cells can be recruited to produce new neurons in the brain. However, little is known about these so-called "activation" processes.

8 Apr 2021

Study offers a promising blood test for depression, bipolar disorder

Worldwide, 1 in 4 people will suffer from a depressive episode in their lifetime. While current diagnosis and treatment approaches are largely trial and error, a breakthrough study by Indiana University School of Medicine researchers sheds new light on the biological basis of mood disorders, and offers a promising blood test aimed at a precision medicine approach to treatment.

8 Apr 2021

Moderate cycling during dialysis could improve the heart health of patients with kidney failure

Cycling at moderate intensity during dialysis could drastically improve the heart health of patients with kidney failure and result in significant savings for the NHS, according to new research by the University of Leicester supported by the charity Kidney Research UK and National Institute for Health Research Leicester Biomedical Research Centre.

8 Apr 2021

Nemours receives grant to examine behavioral health intervention for adolescents with Type 1 diabetes

Susana R. Patton, Ph.D., ABPP, CDCES Center Director of the Nemours Center for Healthcare Delivery Science in Florida, has secured a three-year, $900,000 NIH R01 grant entitled, "Coin2Dose: Behavioral economics to promote insulin bolus activity and improve HbA1c in teens." Dr. Patton is the recipient of three concurrent R01 grants.

8 Apr 2021

Phase 2 clinical trial launched in Thailand to evaluate IL-15 agonist as therapy to reduce HIV reservoir

The U.S. Military HIV Research Program (MHRP) at the Walter Reed Army Institute of Research last week launched a Phase 2 clinical trial in Thailand to evaluate an interleukin-15 (IL-15) superagonist, ImmunityBio's Anktiva (also called N-803), administered during acute HIV infection as an experimental therapy to target establishment of the HIV reservoir at a very early stage.

8 Apr 2021

Mutations to autism-associated gene cause a cascade of problems in developing mouse brains

Damage to the autism-associated gene Dyrk1a, sets off a cascade of problems in developing mouse brains, resulting in abnormal growth-factor signaling, undergrowth of neurons, smaller-than-average brain size, and, eventually, autism-like behaviors, a new study from Scripps Research, Florida, finds.

8 Apr 2021

Research News and Research

Surgery to correct congenital heart disease linked to increased risk of adult hypertension

Novel diarylamides show promise as orally active diuretics to treat hyponatremia

Research offers an efficient approach to mine the chemical diversity of endophytic fungi

Full assembly of human chromosome 8 reveals novel genes, disease risks

Real-time imaging shines light on the coordination of neural stem cell activation

Study offers a promising blood test for depression, bipolar disorder

Moderate cycling during dialysis could improve the heart health of patients with kidney failure

Nemours receives grant to examine behavioral health intervention for adolescents with Type 1 diabetes

Phase 2 clinical trial launched in Thailand to evaluate IL-15 agonist as therapy to reduce HIV reservoir

Mutations to autism-associated gene cause a cascade of problems in developing mouse brains

Holocaust survivors have lingering health impacts

Researchers discover unique regenerative property of cells in the early human embryo

Acrylamide-based novel DHODH inhibitors as potential treatment for rheumatoid arthritis

New tool helps measure communication development in youth with Down syndrome

Study links chronic sinus inflammation with alterations in brain activity

IRB Barcelona researchers find the Achilles heel of some lung tumors

Hispanic immigrants of working age more likely to die of COVID-19 than non-Hispanics

USC Stem Cell scientist receives $2.56 million NIH grant to explore 'synthetic' embryonic development

FDA announces new action plan for reducing dietary exposures to toxic elements for children

Novel mRNA delivery system produces a therapeutic protein that protects neurons from ischemia

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