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Researchers identify ion channel switches that regulate dopamine release in the brain

Researchers have identified two ion channel switches that regulate the release of dopamine in the brain, a first step that might one day lead to therapeutics for a wide range of diseases and disorders that currently have few solutions.

11 Aug 2023

Glucokinase activators induce hepatic lipid accumulation in mice with high-fat diet

The researchers demonstrated that glucokinase activation was effective in lowering blood glucose in mice with high-fat diet-induced obesity, while it potentially raised the risk of increasing hepatic lipid accumulation that triggered the PERK-UPR pathway.

11 Aug 2023

Study identifies 135 genes associated with human skin color

The skin, hair and eye color of more than eight billion humans is determined by the light-absorbing pigment known as melanin.

11 Aug 2023

Illustrating the safety of a new drug treatment designed for spinal cord injury

New orally available drug for spinal cord injury found to be safe and tolerable in healthy participants.

11 Aug 2023

A third dose boosted cross-protection against SARS-CoV-2 viral variants, finds study

Transplant recipients must take life-long immunosuppressive medications to prevent rejection, but these drugs can compromise the effectiveness of vaccines.

11 Aug 2023

Brain development linked to the emergence of autism spectrum disorder

Two distinct neurodevelopmental abnormalities that arise just weeks after the start of brain development have been associated with the emergence of autism spectrum disorder, according to a new Yale-led study in which researchers developed brain organoids from the stem cells of boys diagnosed with the disorder.

10 Aug 2023

Study explores the use of existing medicines to revolutionize cancer treatment

In a recent study published in the journal of Genes & Diseases, Research team led by Lu explores the potential for the use of FDA-approved hypertension and EMA-approved cough medicines to revolutionize cancer treatment.

10 Aug 2023

Diverse gut microbiome may help children survive stem cell transplant

Researchers in Italy have shown for the first time that among children who have undergone a donor stem cell transplant, the presence of diverse species of micro-organisms in the intestinal tract before the transplant resulted in significantly better overall patient survival and fewer complications.

10 Aug 2023

Machine learning can accurately predict subtypes of Parkinson's disease

Researchers at the Francis Crick Institute and UCL Queen Square Institute of Neurology, working with technology company Faculty AI, have shown that machine learning can accurately predict subtypes of Parkinson's disease using images of patient-derived stem cells.

10 Aug 2023

New gene-editing tool helps to study single-base mutations in cancer

A change in just one letter in the code that makes up a cancer-causing gene can significantly affect how aggressive a tumor is or how well a patient with cancer responds to a particular therapy.

10 Aug 2023

KFF Health News' 'What the Health?': On abortion rights, Ohio is the new Kansas

Ohio voters — in a rare August election — turned out in unexpectedly high numbers to defeat a ballot measure that would have made it harder to pass an abortion-rights constitutional amendment on the ballot in November.

10 Aug 2023

Tiny particles made from red blood cells may treat atherosclerosis and other diseases

Atherosclerosis is a disease in which fat, cholesterol, and other substances build up inside artery walls. This can lead to plaque formation, which can block arteries and cause heart attacks and strokes.

10 Aug 2023

Good Trials Prism: A new partnership to enhance clinical research in low resource settings

Four major clinical trial networks based in low resource settings are embarking on an exciting partnership with the Good Clinical Trials Collaborative to enhance clinical research in low resource settings.

10 Aug 2023

Experimental drug can reduce symptoms of inflammatory bowel disease in pre-clinical models

A new study of mice and lab-grown human colon "organoids" indicates that an experimental drug developed by Johns Hopkins Medicine researchers can substantially reduce symptoms of inflammatory bowel disease (IBD) in pre-clinical models.

10 Aug 2023

Scientists discover a therapeutic target for Alzheimer's disease

Scientists at Université Laval and the University of Lethbridge have succeeded in reversing certain cognitive manifestations associated with Alzheimer's disease in an animal model of the disease.

10 Aug 2023

New pathway for HIV to enter nucleus of healthy cells identified

A study published on August 10, 2023 in the journal Nature Communications has identified a new pathway that human immune deficiency virus (HIV) uses to enter the nucleus of a healthy cell, where it can then replicate and go on to invade other cells.

10 Aug 2023

Newly identified helicase might hold the key to a novel family of anti-COVID-19 drugs

Researchers used a multidisciplinary approach to investigate a nonstructural protein essential in SARS-CoV-2 replication.

10 Aug 2023

The role of estrogen in osteoarthritis and lower back pain

Researchers review existing evidence on the association between estrogen, osteoarthritis, and lower back pain.

10 Aug 2023

Exploring molecular mechanisms and genetic dysregulation in aging and age-associated diseases

Researchers review existing data on the molecular basis of senescence and neurodegeneration in age-related brain diseases.

10 Aug 2023

Revolutionizing type 2 diabetes treatment: personalized approach shows promise in matching patients with optimal glucose-lowering therapies

A personalized therapy selection algorithm for two diabetes type 2 (T2D) treatment drug classes.

10 Aug 2023

Drugs News and Research

Researchers identify ion channel switches that regulate dopamine release in the brain

Glucokinase activators induce hepatic lipid accumulation in mice with high-fat diet

Study identifies 135 genes associated with human skin color

Illustrating the safety of a new drug treatment designed for spinal cord injury

A third dose boosted cross-protection against SARS-CoV-2 viral variants, finds study

Brain development linked to the emergence of autism spectrum disorder

Study explores the use of existing medicines to revolutionize cancer treatment

Diverse gut microbiome may help children survive stem cell transplant

Machine learning can accurately predict subtypes of Parkinson's disease

New gene-editing tool helps to study single-base mutations in cancer

KFF Health News' 'What the Health?': On abortion rights, Ohio is the new Kansas

Tiny particles made from red blood cells may treat atherosclerosis and other diseases

Good Trials Prism: A new partnership to enhance clinical research in low resource settings

Experimental drug can reduce symptoms of inflammatory bowel disease in pre-clinical models

Scientists discover a therapeutic target for Alzheimer's disease

New pathway for HIV to enter nucleus of healthy cells identified

Newly identified helicase might hold the key to a novel family of anti-COVID-19 drugs

The role of estrogen in osteoarthritis and lower back pain

Exploring molecular mechanisms and genetic dysregulation in aging and age-associated diseases

Revolutionizing type 2 diabetes treatment: personalized approach shows promise in matching patients with optimal glucose-lowering therapies

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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