Insulin News and Research

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Insulin is a hormone that is needed to convert glucose, starches and other food into energy needed for daily life. Insulin allows cells to use glucose for fuel and is secreted by beta cells in the islets of Langerhans. The release of insulin from the pancreas is stimulated by increased blood glucose, vagal nerve stimulation, and other factors. Insulin is obtained from various animals and available in a variety of preparations. Commercial insulin preparations differ in a number of ways, including differences in the animal species from which they are obtained; their purity, concentration, and solubility; and the time of onset and duration of their biologic action. An oral hypoglycemic agent is not a form of insulin therapy.

First U.S. outpatient trial of UVA-developed artificial pancreas

The University of Virginia School of Medicine has launched the first U.S. outpatient trial of a UVA-developed artificial pancreas that could make it easier for type 1 diabetes patients to manage their condition.

14 May 2012

mTOR protein plays a key role in development of diabetes

The signaling protein mTOR is a key regulator that controls cell growth. Dysfunction of mTOR increases not only the likelihood of developing cancer but also diabetes. In the current issue of the journal Cell Metabolism, Mike Hall and his team from the Biozentrum of the University of Basel describe how inhibition of mTOR signaling can impair carbohydrate metabolism and potentially lead to diabetes.

14 May 2012

Phase II trial to examine effects of resveratrol on individuals with mild to moderate dementia

A national, phase II clinical trial examining the effects of resveratrol on individuals with mild to moderate dementia due to Alzheimer's disease has begun as more than two dozen academic institutions recruit volunteers in the coming months. R. Scott Turner, M.D., Ph.D., director of Georgetown University Medical Center's Memory Disorders Program, is the lead investigator for the national study.

14 May 2012

Lot of fat and few carbohydrates could have better effect on blood sugar levels, lipids in diabetics

People with Type 2 diabetes are usually advised to keep a low-fat diet. Now, a study at Linköping University shows that food with a lot of fat and few carbohydrates could have a better effect on blood sugar levels and blood lipids.

11 May 2012

New combination therapy offers potential lifetime cure for advanced type 1 diabetes

City of Hope researchers developed a combination therapy to treat late-stage type 1 diabetes that appears to offer a potential lifetime cure for the disease without toxic side effects. The laboratory study is published in the May 9 edition of Science Translational Medicine.

11 May 2012

Hygieia’s DIGS automatically adjusts insulin dosage in patients with diabetes

Newly published results from a clinical study of the Diabetes Insulin Guidance System (DIGS-), under development by Hygieia, Inc., demonstrate DIGS' potential to improve blood glucose control for insulin-using patients with type 2 or type 1 diabetes. DIGS automatically adjusted insulin dosage based on each individual's reported blood glucose results.

10 May 2012

Obese women more likely to have children with lower cognitive function

Women who are obese before they become pregnant are at higher risk of having children with lower cognitive function - as measured by math and reading tests taken between ages 5 to 7 years - than are mothers with a healthy prepregnancy weight, new research suggests.

9 May 2012

Positive results from PROLOR Biotech's hGH-CTP Phase II trial for growth hormone deficiency

PROLOR Biotech, Inc. today reported top-line results from a Phase II four-month treatment extension study of hGH-CTP, its long-acting version of human growth hormone, in growth hormone deficient adults.

7 May 2012

Researchers discover how diabetes affects specific brain area leading to memory loss

Badly controlled diabetes are known to affect the brain causing memory and learning problems and even an increased incidence of dementia, although how this occurs is not clear.

7 May 2012

Cordoning off of lipids of the liver helps manage insulin resistance in the body

A Penn research team, led by Mitchell Lazar, MD, PhD, director of the Institute for Diabetes, Obesity, and Metabolism at the Perelman School of Medicine, University of Pennsylvania, reports in Nature Medicine that mice in which an enzyme called histone deacetylase 3 (HDAC3) was deleted had massively fatty livers, but lower blood sugar, and were thus protected from glucose intolerance and insulin resistance, the hallmark of diabetes.

7 May 2012

Dilp8 provides an important signal to slow body growth and delay insect development

Two independent groups of researchers have identified a hormone that is responsible for keeping the growth and development of insects on track. The results, which are reported in the journal Science, suggest that Dilp8 provides an important signal to slow body growth and delay insect development.

5 May 2012

Low levels of testosterone in men could increase risk of diabetes

Low levels of testosterone in men could increase their risk of developing diabetes, a study suggests.

5 May 2012

Flavan-3-ols, SoyLife can improve biomarkers of CVD risk in postmenopausal type 2 diabetic patients

A new, one-year, double-blind controlled clinical study shows that cacao-flavonoids and soy isoflavones can significantly improve biomarkers of CVD risk in postmenopausal women with type 2 diabetes.

5 May 2012

Isis commences ISIS-APOCIIIRx Phase 2 study in hypertriglyceridemia

Isis Pharmaceuticals, Inc. announced the initiation of a Phase 2 study evaluating ISIS-APOCIIIRx in patients with hypertriglyceridemia.

5 May 2012

Growing role of body image drugs

In the current issue of Psychotherapy and Psychosomatics Kanayama et al. analyse the growing role of body image drugs.

4 May 2012

Jogging may add years to life: Study

According to a new study from Denmark, jogging regularly may help a person live longer. The findings show that women who regularly jogged lived 5.6 years longer than women who didn't, and men who jogged lived 6.2 years longer than those who didn't.

4 May 2012

Regular jogging increases life expectancy

Undertaking regular jogging increases the life expectancy of men by 6.2 years and women by 5.6 years, reveals the latest data from the Copenhagen City Heart study presented at the EuroPRevent2012 meeting.

4 May 2012

Lexicon to receive funding for LX4211 Phase 2 trial in type 1 diabetes

Lexicon Pharmaceuticals, Inc. announced today that an independent, non-profit organization will provide funding to support the Phase 2 development of LX4211 in type 1 diabetes.

4 May 2012

IGF-axis proteins may have a role in development of type 2 diabetes

Researchers at Albert Einstein College of Medicine of Yeshiva University in collaboration with Nurses' Health Study investigators have shown that levels of certain related proteins found in blood are associated with a greatly reduced risk for developing type 2 diabetes up to a decade or more later. The findings, published today in the online edition of Diabetes, could open a new front in the war against diabetes.

4 May 2012

High fructose intake may increase risk of NFALD in obese people

Obese people who consume increased amounts of fructose, a type of sugar that is found in particular in soft drinks and fruit juices, are at risk for nonalcoholic fatty liver disease (NFALD) and more its more severe forms, fatty inflammation and scarring.

3 May 2012

Insulin News and Research

Further Reading

First U.S. outpatient trial of UVA-developed artificial pancreas

mTOR protein plays a key role in development of diabetes

Phase II trial to examine effects of resveratrol on individuals with mild to moderate dementia

Lot of fat and few carbohydrates could have better effect on blood sugar levels, lipids in diabetics

New combination therapy offers potential lifetime cure for advanced type 1 diabetes

Hygieia’s DIGS automatically adjusts insulin dosage in patients with diabetes

Obese women more likely to have children with lower cognitive function

Positive results from PROLOR Biotech's hGH-CTP Phase II trial for growth hormone deficiency

Researchers discover how diabetes affects specific brain area leading to memory loss

Cordoning off of lipids of the liver helps manage insulin resistance in the body

Dilp8 provides an important signal to slow body growth and delay insect development

Low levels of testosterone in men could increase risk of diabetes

Flavan-3-ols, SoyLife can improve biomarkers of CVD risk in postmenopausal type 2 diabetic patients

Isis commences ISIS-APOCIIIRx Phase 2 study in hypertriglyceridemia

Growing role of body image drugs

Jogging may add years to life: Study

Regular jogging increases life expectancy

Lexicon to receive funding for LX4211 Phase 2 trial in type 1 diabetes

IGF-axis proteins may have a role in development of type 2 diabetes

High fructose intake may increase risk of NFALD in obese people

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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