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Researchers develop a stable nano-carrier for medications

Medications often have unwanted side-effects. One reason is that they reach not only the unhealthy cells for which they are intended, but also reach and have an impact on healthy cells.

25 Sep 2020

Study identifies potential drug target for dangerous E. coli infections

Escherichia coli, known as E. coli, are bacteria which many people associate with causing mild food poisoning, but some types of E. coli can be fatal.

25 Sep 2020

Alzheimer’s disease-associated protective genetic variant enhances key functions of immune cells

A new study conducted by researchers at the University of Eastern Finland found that the PLCG2-P522R genetic variant, which protects against Alzheimer's disease, enhances several key functions of immune cells. The results obtained in the study highlight the importance of immune cells as a target of future development of new therapies for Alzheimer's disease.

25 Sep 2020

Study sheds new light on the role of Y chromosome genes

New light is being shed on a little-known role of Y chromosome genes, specific to males, that could explain why men suffer differently than women from various diseases, including Covid-19.

25 Sep 2020

D614G mutation now the dominant variant in the global COVID-19 pandemic

Now, a new study published on the preprint server medRxiv in September 2020 shows that a significant variant characterized by the D614G mutation has higher infectivity, which may account for its rapid rise to the dominant position in all regions where it has emerged.

25 Sep 2020

New studies report specific mechanisms of impaired type I interferon signaling in COVID-19 patients

Two new studies report specific mechanisms of impaired type I interferon (IFN) signaling in some hospitalized patients suffering from severe cases of COVID-19, suggesting that screens for these defects could help identify patients at the highest risk of life-threatening complications from SARS-CoV-2 infection.

25 Sep 2020

Scientists to use CRISPR gene-editing technology for Phase 1 vaccine trials in humans

Scientists are planning for Phase 1 human trials of a vaccine they developed by using CRISPR gene-editing technology to mutate the parasite that causes leishmaniasis, a skin disease common in tropical regions of the world and gaining ground in the United States

25 Sep 2020

Individuals with severe forms of COVID-19 disease can have compromised type I interferon responses

Individuals with severe forms of COVID-19 disease can present with compromised type I interferon (IFN) responses based on their genetics, according to results published in two papers today in the journal Science.

25 Sep 2020

New tool enables big data analysis without specialized expertise in bioinformatics

A new data analysis tool developed by researchers at The University of Texas MD Anderson Cancer Center incorporates a user-friendly, natural-language interface to allow biomedical researchers without specialized expertise in bioinformatics or programming languages to conduct intuitive analysis of large datasets.

25 Sep 2020

Human-to-cat transmission of SARS-CoV-2 confirmed

Cat-to-cat transmission of SARS-CoV-2 has been experimentally proven, but little is known about the significance of this novel virus as a feline pathogen or its reverse zoonotic potential. The establishment of new animal reservoirs of SARS-CoV-2 could pose serious problems for human health in the future.

24 Sep 2020

Genetic variation not linked with differences in COVID-19 morbidity and mortality

A comprehensive search of genetic variation databases has revealed no significant differences across populations and ethnic groups in seven genes associated with viral entry of SARS-CoV-2.

24 Sep 2020

Prevalence of SARS-CoV-2 with D614G mutation in a second wave infection in Houston

A recent study reveals that the genetic variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detected in the initial phase of coronavirus disease 2019 (COVID-19) pandemic differ from the variants detected in a massive second wave of infection in Houston, Texas. The study is currently available on the medRxiv preprint server.

24 Sep 2020

Cellular and molecular map of the human heart could guide personalized medicine

Scientists have created a cellular and molecular map of the healthy human heart, to understand how this vital organ functions, and to shed light on what goes wrong in cardiovascular disease.

24 Sep 2020

Molecular analysis of COVID-19's second wave shows mutant viruses linked to rapid spread

Molecular analysis of COVID-19's powerful second wave in Houston – from May 12 to July 7 – shows a mutated virus strain linked to higher transmission and infection rates than the coronavirus strains that caused Houston's first wave.

24 Sep 2020

Elegant, efficient way to find recombinant SARS-CoV-2 viruses from >85,000 genomes

The low divergence of near-identical genomes that are sequenced in short periods presents a statistical challenge that is not addressed by methods available currently. In a recent bioRxiv** paper, Ales Varabyou et al. from John Hopkins University present an efficient method designed to detect recombination and reassortment events between clades of viral genomes – a new algorithm called ‘Bolotie’.

23 Sep 2020

Bat and pangolin coronavirus structure sheds light on SARS-CoV-2 evolution

Researchers at Tsinghua University, Beijing, have conducted a study providing possible new insights into the evolution and cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

23 Sep 2020

OXGENE launches a scalable, plasmid-free manufacturing system for AAV

OXGENE™, a biotechnology company designing and developing scalable gene therapy technologies, has today announced the launch of its scalable, plasmid-free manufacturing system for AAV.

From OXGENE 23 Sep 2020

Bioinformatics analysis reveals genes and pathways shared in COVID-19 disease and comorbidities

Using bioinformatics approaches, researchers have identified genes and pathways shared among patients with comorbidities and having severe COVID-19. The research is published on the preprint server bioRxiv in September 2020.

23 Sep 2020

Molecular dynamic simulations reveal detailed spike-ACE2 interactions

The current COVID-19 pandemic has spread throughout the world. Caused by a single-stranded RNA betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is closely related to but much more infectious than the earlier highly pathogenic betacoronaviruses SARS and MERS-CoV, has impacted social, economic, and physical health to an unimaginable extent.

23 Sep 2020

Confirmed early re-infection with SARS-CoV-2

As scientists strive to develop commercially viable and effective antivirals and vaccines to counter the growing COVID-19 pandemic, there is considerable uncertainty about how long and how durable the immunity induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is. A new paper recently published in the journal Clinical Infectious Disease in September 2020 reports a confirmed case of re-infection with this virus following recovery.

22 Sep 2020

Genome News and Research

Researchers develop a stable nano-carrier for medications

Study identifies potential drug target for dangerous E. coli infections

Alzheimer’s disease-associated protective genetic variant enhances key functions of immune cells

Study sheds new light on the role of Y chromosome genes

D614G mutation now the dominant variant in the global COVID-19 pandemic

New studies report specific mechanisms of impaired type I interferon signaling in COVID-19 patients

Scientists to use CRISPR gene-editing technology for Phase 1 vaccine trials in humans

Individuals with severe forms of COVID-19 disease can have compromised type I interferon responses

New tool enables big data analysis without specialized expertise in bioinformatics

Human-to-cat transmission of SARS-CoV-2 confirmed

Genetic variation not linked with differences in COVID-19 morbidity and mortality

Prevalence of SARS-CoV-2 with D614G mutation in a second wave infection in Houston

Cellular and molecular map of the human heart could guide personalized medicine

Molecular analysis of COVID-19's second wave shows mutant viruses linked to rapid spread

Elegant, efficient way to find recombinant SARS-CoV-2 viruses from >85,000 genomes

Bat and pangolin coronavirus structure sheds light on SARS-CoV-2 evolution

OXGENE launches a scalable, plasmid-free manufacturing system for AAV

Bioinformatics analysis reveals genes and pathways shared in COVID-19 disease and comorbidities

Molecular dynamic simulations reveal detailed spike-ACE2 interactions

Confirmed early re-infection with SARS-CoV-2

Genetics & Genomics - Second Edition eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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