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New test for heart disease

Building on years of research on the way that blood flows through the heart valves, researchers from the California Institute of Technology and Oregon Health Science University have devised a new index for cardiac health based on a simple ultrasound test.

18 Apr 2006

Placental growth factor may help body repair heart attack damage

Heart attack patients produce higher levels of a natural substance in the body that plays a role in the growth of new blood vessels and this over-expression of placental growth factor (PlGF) may help reduce damage to the heart muscle

17 Apr 2006

First evidence that circulating endothelial microparticles lead to heart valve disease

Under normal physiological conditions, low levels of microparticles are continually being shed into the blood from the endothelium - the cells that line the inside of blood vessels and some organs -and appear to cause no problems.

13 Apr 2006

Research explains why recipients of growth hormone therapy may develop colon polyps

The use of growth hormone therapy has been linked in some people to the development of colon polyps, a possible precursor to colorectal cancer - but medical researchers have debated the extent of a cancer risk.

11 Apr 2006

Protein loss linked to colon polyp risk from growth hormone

10 Apr 2006

Genome evolution in gibbons erased fat gene

Scientists from The University of Tokyo have discovered that gibbons, arboreal primates that inhabit the jungles of Southeast Asia, do not carry a major obesity gene that is present in the genomes of all other primates, including humans.

4 Apr 2006

HIV reveals another secret to its success

In HIV infection, a protein produced by infected cells penetrates immune B cells, preventing them from producing antibodies that could do the virus real harm.

20 Mar 2006

Salmonella research provides clues to antibiotic development

Pathogens are becoming increasingly resistant to antibiotics, causing problems for therapy. Doctors need to have antibiotics available that work in new kinds of ways.

19 Mar 2006

Inefficient cytotoxic T lymphocyte mediated killing of HIV-1 infected cells in vivo

HIV attacks the immune system by infecting and killing helper T lymphocytes (also called CD4 T cells), the white blood cells responsible for mobilizing the mediators of an immune response.

15 Mar 2006

New AF267B drug reverses key cognitive deficits, pathology in Alzheimer's

A new drug that enhances the activity of a key brain cell receptor involved in Alzheimer's disease (AD) reverses learning and memory deficits in mice engineered to have pathological hallmarks of the disease.

13 Mar 2006

New genome-wide map of miRNA-MRNA interactions

Researchers at New York University's Center for Comparative Functional Genomics and the University of California, Berkeley have used computational analyses to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans).

9 Mar 2006

Major biomarker candidates for Alzheimer's disease explored

Alzheimer's disease - specific biomarkers clearly are needed for the differential diagnosis of cognitive impairment in the elderly.

8 Mar 2006

Hydrogel scaffold materials used to create stable networks of blood vessels

Yale biomedical engineers have created an implantable system that can form and stabilize a functional network of fine blood vessels critical for supporting tissues in the body, according to a report in the Proceedings of the National Academy of Sciences.

1 Mar 2006

Researchers transplant insulin-producing neonatal porcine islet cells into monkeys

A team of researchers from the University of Alberta, the Yerkes National Primate Research Center of Emory University and the Emory Transplant Center has successfully transplanted insulin-producing neonatal porcine islet cells into monkeys, a procedure the researchers say represents a promising intermediate solution to the critical supply problem in clinical islet cell transplantation.

27 Feb 2006

PET and MR imaging reveals white matter degeneration in Huntington's

Using both brain function (PET) and anatomical structure (MR) imaging studies, Italian researchers - within the context of an Italian-British collaboration - discovered that degenerative and dysfunctional events occur in individuals many years before the onset of Huntington's disease - particularly in the brain's white matter - an area not previously considered primarily involved with the disease.

24 Feb 2006

Selective T cell stimulation could help improve treatment of autoimmune disease and cancer

The findings could also be significant for developing new ways to help patients with autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, or juvenile diabetes.

23 Feb 2006

Scientists map brain area that may help find human brain stem cells

A study led by a Johns Hopkins neurosurgeon has provided the first comprehensive map of a part of the adult human brain containing astrocytes, cells known to produce growth factors critical to the regeneration of damaged neural tissue and that potentially serve as brain stem cells.

17 Feb 2006

Rett disease progression altered by changing expression of gene

Scientists from the Whitehead Institute for Biomedical Research, Brandeis University and Massachusetts Institute of Technology report in the journal Neuron that increasing levels of brain derived neurotrophic factor (BDNF) alleviates symptoms in a mouse model of the childhood disorder Rett Syndrome.

13 Feb 2006

Changes in the tissue environment of the breast that occur after pregnancy promote the metastasis of breast tumor cells

Changes in the tissue environment of the breast that occur after pregnancy promote the metastasis of breast tumor cells. The paper by McDaniel et al., "Remodeling of the mammary microenvironment following lactation promotes breast tumor cell metastasis.

12 Feb 2006

Viragen reports on Multiferon anti-viral studies

Viragen, Inc today reported on the progression of anti-viral studies using Multiferon (multi-subtype, natural human alpha interferon) being conducted by the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID).

7 Feb 2006