Nitric Oxide News and Research

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UNSW-developed nanoparticle could improve effectiveness of chemotherapy for neuroblastoma

In a world-first, researchers from the Australian Centre for Nanomedicine at the University of New South Wales (UNSW) in Sydney have developed a nanoparticle that could improve the effectiveness of chemotherapy for neuroblastoma by a factor of five.

21 Nov 2012

Tug of war between Hsp70 and 90 determines how much the body makes of superoxide

Two proteins are in a tug of war that determines how much the body makes of superoxide, a highly reactive and potentially destructive product of oxygen that's dramatically elevated in cardiovascular disease, researchers report.

16 Nov 2012

Taste receptor governs respiratory infection susceptibility

The bitter taste receptor TAS2R38 may play a role in innate defense, say researchers, who have found that variations in the TAS2R38 gene may regulate susceptibility to respiratory infection.

12 Nov 2012

HCT 1026 may help stem debilitating effects of muscular dystrophy

Cedars-Sinai Heart Institute researchers have found that an experimental compound may help stem the debilitating effects of muscular dystrophy by restoring normal blood flow to muscles affected by the genetic disorder.

9 Nov 2012

Urban outdoor aerobic training may have negative health effects

Training outside in an urban environment may not be as beneficial for a person’s health as they might hope, suggests research.

5 Nov 2012

Downregulated protein could be revascularization target in critical limb ischemia

Levels of calcium-sensor protein, S100A1, are downregulated in patients with critical limb ischemia, say researchers who believe the protein could be a potential therapeutic target to promote revascularization.

12 Oct 2012

S100A1 protein critical for endothelial cell function in ischemic angiogenesis

Restoring diminished levels of a protein shown to prevent and reverse heart failure damage could also have therapeutic applications for patients with critical limb ischemia (CLI), suggests a new preclinical study published online October 9 in Circulation Research from researchers at the Center for Translational Medicine at Thomas Jefferson University.

11 Oct 2012

People with SIRT1 genetic variation more likely to develop vibration-induced white finger disease

Vibration-induced white finger disease (VWF) is caused by continued use of vibrating hand held machinery (high frequency vibration >50 Hz), and affects tens of thousands of people. New research published in BioMed Central's open access journal Clinical Epigenetics finds that people with a genetic polymorphism (A2191G) in sirtuin1 (SIRT1), a protein involved in the regulation of endothelial NOS (eNOS), are more likely to suffer from vibration-induced white finger disease.

1 Oct 2012

Article reveals biochemical chain of events involved in penile erection

For two decades, scientists have known the biochemical factors that trigger penile erection, but not what's needed to maintain one. Now an article by Johns Hopkins researchers, scheduled to be published this week by the Proceedings of the National Academy of Sciences (PNAS), uncovers the biochemical chain of events involved in that process.

27 Sep 2012

Researchers to probe causes, treatments of toxic reactions in blood plasma

In the largest undertaking of its kind, scientists at four leading U.S. research institutions are embarking upon a five-year National Institutes of Health (NIH)-funded study to make blood transfusions safer and more effective by uncovering the exact causes of hemoglobin toxicity.

18 Sep 2012

vasopharm's explorative phase IIa NOSTRA trial in TBI meets clinical endpoints for safety

vasopharm GmbH, a pharmaceutical company dedicated to the discovery and development of novel therapeutics for the treatment of cerebro- and cardiovascular diseases, today announces that the explorative phase IIa NOSTRA trial in Traumatic Brain Injury Patients met all clinical endpoints for safety and in addition demonstrated strong evidence of clinical benefit in patients.

17 Sep 2012

Pancreatic trigs trigger diabetes

Researchers have found that pancreatic triglycerides provide a novel biomarker for pancreatic β-cell dysfunction that can be used to identify individuals at risk for Type 2 diabetes, particularly among people of Hispanic origin.

14 Sep 2012

Alcohol douses the blood pressure benefit of red wine

Alcohol-free red wine Is more effective at lowering blood pressure than traditional red wine or gin, a study shows.

13 Sep 2012

Daily low-dose inhaled corticosteroids do not benefit asthmatics

For two decades, asthma treatment for millions of people with a milder form of the disease has consisted of daily inhaled steroid medicine to reduce inflammation. Now, a new study has found that asthmatics who take the low-dose medication as a daily routine do no better than those who turn to their inhalers only when they have symptoms.

12 Sep 2012

Oxyphenbutazone can kill drug resistant TB

An off-patent anti-inflammatory drug that costs around two cents for a daily dose in developing countries has been found by researchers at Weill Cornell Medical College to kill both replicating and non-replicating drug resistant tuberculosis in the laboratory -- a feat few currently approved TB drugs can do, and resistance to those is spreading.

11 Sep 2012

Phthalates may be asthma trigger

Research suggests that exposure to two phthalates may be a trigger for asthma-related airway inflammation.

7 Sep 2012

Exposure to phthalates increases risk of asthma-related airway inflammation in children

Children exposed to diethyl phthalate (DEP) and butylbenzyl phthalate (BBzP)-phthalate chemicals commonly found in personal care and plastic products-have elevated risk of asthma-related airway inflammation, according to researchers at Columbia Center for Children's Environmental Health (CCCEH) at the Mailman School of Public Health.

6 Sep 2012

Tunes and T-shirts for cardiac rehabilitation

Two studies presented at the European Society of Cardiology Congress in Munich, Germany, showed how researchers are developing innovative approaches to help patients get the most out of cardiac rehabilitation.

31 Aug 2012

Tunes and T-shirts for cardiac rehabilitation

29 Aug 2012

Trudeau Institute study holds promise for improved prevention and treatment of bacterial infections

New research from the laboratory of Dr. Andrea Cooper at the Trudeau Institute, just published in the European Journal of Immunology, holds promise for the improved prevention and treatment of bacterial infections and the life-threatening complications of chronic inflammation that can result from them.

29 Aug 2012

Nitric Oxide News and Research

UNSW-developed nanoparticle could improve effectiveness of chemotherapy for neuroblastoma

Tug of war between Hsp70 and 90 determines how much the body makes of superoxide

Taste receptor governs respiratory infection susceptibility

HCT 1026 may help stem debilitating effects of muscular dystrophy

Urban outdoor aerobic training may have negative health effects

Downregulated protein could be revascularization target in critical limb ischemia

S100A1 protein critical for endothelial cell function in ischemic angiogenesis

People with SIRT1 genetic variation more likely to develop vibration-induced white finger disease

Article reveals biochemical chain of events involved in penile erection

Researchers to probe causes, treatments of toxic reactions in blood plasma

vasopharm's explorative phase IIa NOSTRA trial in TBI meets clinical endpoints for safety

Pancreatic trigs trigger diabetes

Alcohol douses the blood pressure benefit of red wine

Daily low-dose inhaled corticosteroids do not benefit asthmatics

Oxyphenbutazone can kill drug resistant TB

Phthalates may be asthma trigger

Exposure to phthalates increases risk of asthma-related airway inflammation in children

Tunes and T-shirts for cardiac rehabilitation

Tunes and T-shirts for cardiac rehabilitation

Trudeau Institute study holds promise for improved prevention and treatment of bacterial infections

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