Polymerase Chain Reaction News and Research

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Polymerase chain reaction (PCR) is a revolutionary laboratory technique that enables the replication of a specific DNA sequence. Using PCR, millions of copies of a target DNA can be easily synthesized within a short period of time.

Bombali ebolavirus has been detected among bats in Mozambique

Researchers reported on the detection of Bombali virus (BOMV, of the ebolavirus genus) ribonucleic acid (RNA) among three free-tailed Mops condylurus (Molossidae) bat species in Mozambique.

18 Nov 2022

What is the immune protection generated by SARS-CoV-2 Delta and Omicron BA.1 and BA.2 against Omicron BA.4 and BA.5?

Researchers evaluated immune protection conferred by previous SARS-CoV-2 Delta variant and Omicron BA.1/BA.2 subvariant infections and updated vaccines against Omicron BA.4/5 infections and associated hospitalizations.

17 Nov 2022

What is the prevalence of contraindications to Paxlovid among hospitalized COVID-19 patients?

Researchers examined the prevalence of contraindications to nirmatrelvir-ritonavir (Paxlovid) in hospitalized coronavirus disease 2019 (COVID-19) patients.

17 Nov 2022

Comparing post–COVID-19 symptoms two years after SARS-CoV-2 infection

Researchers compared the presence of post–coronavirus disease 2019 (COVID-19) symptoms among hospitalized and non-hospitalized patients in Spain.

17 Nov 2022

Study concludes monkeypox virus is readily detected by qPCR using three clinically validated assays

Researchers validated monkeypox virus (MPXV) quantitative polymerase chain reaction (qPCR) assays.

17 Nov 2022

SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

Researchers characterized the expression of IFN-1 and IFN-2, ISGs, and NF-κB in the upper respiratory tracts of patients with mild and severe COVID-19, to understand innate immune responses to SARS-CoV-2 infections.

17 Nov 2022

Omicron BA.2 causes more symptoms and a greater disruption to daily life

In a recent study published in the Nature Communications journal, researchers monitored the changing symptom profiles associated with different severe acute respiratory syndrome CoV-2 (SARS-CoV-2) variants, especially Omicron subvariants BA.1 and BA.2.

16 Nov 2022

Could self-collected swabs play a role in the diagnosis and control of monkeypox?

In a recent study published in the journal Clinical Infectious Diseases, researchers evaluated the accuracy of patient-collected samples in diagnosing monkeypox virus infections.

16 Nov 2022

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

In a recent study published in the journal npj Vaccines, researchers in China designed, produced, and evaluated the neutralization efficacy of a recombinant coronavirus disease 2019 (COVID-19) vaccine containing four hot-spot substitution mutations based on a prefusion-stabilized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) trimer.

15 Nov 2022

Long-COVID symptoms worsened by stressful events

A recent study published in the Journal of Neurological Sciences reported that life stressors impact post-acute symptoms and long-term outcomes after hospitalization for coronavirus disease 2019 (COVID-19).

15 Nov 2022

Black, Hispanic MSM disproportionately affected by monkeypox

A recent study published in the Morbidity and Mortality Weekly Report described the epidemiologic characteristics of the monkeypox (MPX) outbreak in the United States (US).

15 Nov 2022

SARS-CoV-2 transmission among asymptomatic cases is lower

In a recent study published in the BMC Medicine journal, researchers at the Norwegian Institute of Public Health explored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission among asymptomatic cases.

15 Nov 2022

Research sheds light on cardiac pathology mechanisms of COVID-19

Researchers compared cardiac autopsy samples from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive cases with age-matched samples from influenza hemagglutinin 1 neuraminidase 1 (H1N1) cases, non-influenza lymphocytic myocarditis cases, and heart tissue with no inflammation to understand the mechanisms underlying the pathology of the cardiac complications during coronavirus disease 2019 (COVID-19).

15 Nov 2022

Five important things to know about polio

Public Health authorities have warned health care workers to be on the alert for polio, yet most physicians will not be familiar with presentation of this highly infectious, life-threatening disease.

15 Nov 2022

Do SSRIs lower the risk of long COVID?

Researchers conducted a retrospective study to determine whether SSRIs with immunomodulatory and antiplatelet properties can decrease the risk of post-acute sequelae of COVID-19 (PASC).

15 Nov 2022

Short-term outcomes in pregnant patients with COVID-19 who received nirmatrelvir–ritonavir treatment

Researchers investigated the short-term outcomes of treating pregnant patients exhibiting mild to moderate symptoms of COVID-19 with Paxlovid, which is a combination of the antivirals nirmatrelvir and ritonavir.

15 Nov 2022

Study points to a pathogenic role for compromised anti-SARS-CoV-2 responses in cerebrospinal fluid

Researchers used a high throughput systems serology method to compare serum and CSF samples from SARS-CoV-2 infected individuals with and without long COVID symptoms to determine changes in the SARS-CoV-2 humoral immune responses.

15 Nov 2022

What is the post-COVID-19-associated morbidity in German children, adolescents, and adults?

Researchers investigated coronavirus disease 2019 (COVID-19)-associated morbidity in children, adolescents, and adults using healthcare data covering ~46% of the German population.

14 Nov 2022

Study suggests the rapid expansion of naïve T cells can provide a fast and effective immune response to SARS-CoV-2 and other viral infections

Researchers investigated the early T cell responses during SARS-CoV-2 infections to understand the mechanisms of rapid clonal expansion that characterize the T cell responses to acute infections and vaccinations.

14 Nov 2022

SARS-CoV-2 detected in white-tailed deer in Canada

Researchers investigated the detection of SARS-CoV-2 in white-tailed deer.

14 Nov 2022

Polymerase Chain Reaction News and Research

Further Reading

Bombali ebolavirus has been detected among bats in Mozambique

What is the immune protection generated by SARS-CoV-2 Delta and Omicron BA.1 and BA.2 against Omicron BA.4 and BA.5?

What is the prevalence of contraindications to Paxlovid among hospitalized COVID-19 patients?

Comparing post–COVID-19 symptoms two years after SARS-CoV-2 infection

Study concludes monkeypox virus is readily detected by qPCR using three clinically validated assays

SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

Omicron BA.2 causes more symptoms and a greater disruption to daily life

Could self-collected swabs play a role in the diagnosis and control of monkeypox?

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

Long-COVID symptoms worsened by stressful events

Black, Hispanic MSM disproportionately affected by monkeypox

SARS-CoV-2 transmission among asymptomatic cases is lower

Research sheds light on cardiac pathology mechanisms of COVID-19

Five important things to know about polio

Do SSRIs lower the risk of long COVID?

Short-term outcomes in pregnant patients with COVID-19 who received nirmatrelvir–ritonavir treatment

Study points to a pathogenic role for compromised anti-SARS-CoV-2 responses in cerebrospinal fluid

What is the post-COVID-19-associated morbidity in German children, adolescents, and adults?

Study suggests the rapid expansion of naïve T cells can provide a fast and effective immune response to SARS-CoV-2 and other viral infections

SARS-CoV-2 detected in white-tailed deer in Canada

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