Insulin News and Research

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Insulin is a hormone that is needed to convert glucose, starches and other food into energy needed for daily life. Insulin allows cells to use glucose for fuel and is secreted by beta cells in the islets of Langerhans. The release of insulin from the pancreas is stimulated by increased blood glucose, vagal nerve stimulation, and other factors. Insulin is obtained from various animals and available in a variety of preparations. Commercial insulin preparations differ in a number of ways, including differences in the animal species from which they are obtained; their purity, concentration, and solubility; and the time of onset and duration of their biologic action. An oral hypoglycemic agent is not a form of insulin therapy.

Two new studies strongly support link between insulin resistance and Alzheimer's

An emerging body of research suggests that Alzheimer's disease may be linked to insulin resistance, constituting a third type of diabetes. This model is based on several observations including an increased risk of developing Alzheimer's disease for diabetic patients, and reduced insulin levels in the brain tissue of Alzheimer's disease patients. Though intriguing, the existing evidence does not reveal if defective insulin signaling is causative of Alzheimer's or how insulin resistance impacts cognitive function.

21 Mar 2012

Obesity gene mutation identified in mice

A new study has found why a mutation in a particular gene can lead to obesity. Mouse experiments suggested the body's message to “stop eating” was blocked if the animals had the mutation. The study, published in Nature Medicine, said the brain's response to appetite hormones was being disrupted.

20 Mar 2012

UAB to present at annual American College of Cardiology Scientific Sessions

The University of Alabama at Birmingham has a number of presentations and experts available to comment on news being presented at the annual American College of Cardiology Scientific Sessions that begin Saturday, March 23, 2012, in Chicago.

20 Mar 2012

FDA approves key testing phase for artificial pancreas

A University of Virginia-developed artificial pancreas that could potentially automate care for millions of Type 1 diabetes patients has received U.S. Food and Drug Administration (FDA) approval for a key testing phase.

19 Mar 2012

Study reveals how Bdnf gene mutation contributes to severe obesity

Researchers at Georgetown University Medical Center have revealed how a mutation in a single gene is responsible for the inability of neurons to effectively pass along appetite suppressing signals from the body to the right place in the brain. What results is obesity caused by a voracious appetite.

19 Mar 2012

HGF/C-MET signaling pathway plays a key role in gestational diabetes development

Researchers at the University of Pittsburgh School of Medicine have identified a cell-signaling pathway that plays a key role in increasing insulin secretion during pregnancy and, when blocked, leads to the development of gestational diabetes.

17 Mar 2012

Deadly link between higher BMI and colorectal cancer

The American College of Gastroenterology (ACG) and the Campaign to End Obesity (CEO) are joining forces to highlight the potentially deadly link between higher Body Mass Index (BMI) and colorectal cancer.

16 Mar 2012

Low-carb, reduced glycemic load and portion-controlled diets effective for obese children

A new study of three diets with obese children shows that all diets are effective in managing weight but that a reduced glycemic load diet - one that accounts for how many carbs are in the food and how much each gram of carbohydrate raises blood glucose levels - may be most promising.

15 Mar 2012

Consumption of dietary trans fatty acids associated with irritability, aggression

Might the "Twinkie defense" have a scientific foundation after all? Researchers at the University of California, San Diego School of Medicine have shown - by each of a range of measures, in men and women of all ages, in Caucasians and minorities - that consumption of dietary trans fatty acids (dTFAs) is associated with irritability and aggression.

14 Mar 2012

Insulin and nutrition keep blood stem cells from differentiating into mature blood cells

UCLA stem cell researchers have shown that insulin and nutrition keep blood stem cells from differentiating into mature blood cells in Drosophila, the common fruit fly, a finding that has implications for studying inflammatory response and blood development in response to dietary changes in humans.

12 Mar 2012

Gastrointestinal progenitor cells could be coaxed into making insulin

A study by Columbia researchers suggests that cells in the patient's intestine could be coaxed into making insulin, circumventing the need for a stem cell transplant. Until now, stem cell transplants have been seen by many researchers as the ideal way to replace cells lost in type I diabetes and to free patients from insulin injections.

12 Mar 2012

Researchers produce extensive catalog of genes expressed in human islets

A new JDRF-funded study shows that many of the genes known to play a role in type 1 diabetes (T1D) are expressed in pancreatic beta cells, suggesting that the cell responsible for producing insulin may be playing a part in its own destruction to lead to T1D.

12 Mar 2012

Conference highlights studies on metabolism, aging and monarch butterfly migration

The Genetics Society of America's 53rd Annual Drosophila Research Conference, March 7-11 at the Sheraton Chicago Hotel & Towers, will showcase diverse efforts to understand basic biological processes through the easy-to-study fruit fly, Drosophila melanogaster, and other insects.

12 Mar 2012

MEDVAMC initiates Aeterna Zentaris' AEZS-130 Phase 2A trial in cancer cachexia

Aeterna Zentaris Inc. today announced that the Michael E. DeBakey Veterans Affairs Medical Center, in Houston, Texas, has initiated a Phase 2A trial assessing the safety and efficacy of repeated doses of the Company's ghrelin agonist, AEZS-130 (macimorelin), in patients with cancer cachexia.

9 Mar 2012

FDA clears Abbott's FreeStyle InsuLinx Blood Glucose Monitoring System

Abbott today announced that it has received U.S. Food and Drug Administration (FDA) clearance for the FreeStyle InsuLinx Blood Glucose Monitoring System, the first from Abbott to include a touch-screen interface, automated logbook and several personalization features designed to improve the diabetes management experience for patients.

8 Mar 2012

XMetA can control blood glucose levels in patients with diabetes

XOMA Corporation announced that its study of XMetA, the company's fully-human allosteric monoclonal antibody to the insulin receptor, is available online and will be published in the May issue of the American Diabetes Association's journal Diabetes.

8 Mar 2012

Metformin drug appears to prevent growth of atherosclerosis in patients with HIV

Treatment with the common diabetes drug metformin appears to prevent progression of coronary atherosclerosis in patients infected with HIV.

8 Mar 2012

Study suggests how and why high fat diets are linked to colon cancer

Epidemiologists have long warned that, in addition to causing obesity, eating too much fat and sugar puts a person at greater risk for colon cancer. Now, researchers at Temple University have established a link that may explain why.

8 Mar 2012

Lilly, Boehringer Ingelheim announce availability of Jentadueto tablets

Boehringer Ingelheim Pharmaceuticals, Inc. and Eli Lilly and Company today announced Jentadueto (linagliptin/metformin hydrochloride) tablets are now available by prescription in many leading chain and independent pharmacies across the U.S.

8 Mar 2012

U of A study looks at Bim molecule to understand autoimmune diseases

Understanding why immune cells, called T-cells, attack the body is vital in the war against autoimmune diseases like diabetes. University of Alberta researcher Troy Baldwin is a step closer to understanding why the body's T-cells sometimes attack healthy cells causing autoimmune diseases.

7 Mar 2012