Efficacy News and Research

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New nanoparticle SARS-CoV-2 vaccine shows stronger, broader, and more durable protection

The first generation of COVID-19 vaccines have been highly effective, but also have limitations: their efficacy can wane without a booster shot, and they may be less effective against some variants.

2 Feb 2022

COVID-19 vaccines induce robust cellular immune response against SARS-CoV-2 Omicron

A team of scientists from the United States has recently demonstrated that current coronavirus disease 2019 (COVID-19) vaccines induce robust spike-specific T cell responses against the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

1 Feb 2022

Study finds that high-dose convalescent plasma does not improve outcomes for severe COVID-19

A randomized controlled trial assesses the efficacy and safety of high-dose convalescent plasma in the treatment of severe COVID-19.

1 Feb 2022

High levels of neutralizing antibodies against Omicron after BNT162b2 booster vaccination

Researchers analyze the neutralizing antibody levels against SARS-CoV-2 VOCs in individuals after receiving their second and third doses.

1 Feb 2022

C-Path and EJP RD collaborate to expand global rare disease research and drug development

Critical Path Institute (C-Path), an independent global nonprofit organization, and the European Joint Programme on Rare Diseases (EJP RD), an initiative that has received funding from the European Union's Horizon 2020 research and innovation programme, have announced a collaboration to advance technologies and methodologies that are fit for regulatory purposes to further global rare disease research and drug development.

1 Feb 2022

Neural stem cells plus HER2 inhibitor drug improve survival in mice with metastatic cancer

Neural stem cells (NSCs) engineered by Northwestern Medicine investigators used in combination with the HER2 inhibitor drug tucatinib improved survival in mice with HER2-positive breast cancer brain metastases, according to findings published in Proceedings of the National Academy of Sciences.

1 Feb 2022

Assessing the effects of booster vaccinations against SARS-CoV-2 Omicron variant

In a new study, researchers analyzed the effect of vaccine booster doses against the SARS-CoV-2 Omicron variant.

1 Feb 2022

Assessing the neutralizing ability of polyclonal antibody XAV-19 against SARS-CoV-2 Omicron variant

In a new study, a team of researchers assessed the neutralizing activity of XAV-19, a glyco-humanized polyclonal antibody derived from hyperimmunized animal hosts, against the SARS-CoV-2 Omicron variant.

1 Feb 2022

Study shows mRNA booster dose eliminates immune escape observed with SARS-CoV-2 Omicron

Researchers examined total and neutralizing antibodies to the spike protein of SARS-CoV-2, and neutralizing antibodies against Washington-1 (WA-1) and variants of concern (VOC) including Beta, Delta, and Omicron in a longitudinal cohort.

31 Jan 2022

Study highlights importance of immunizing and boosting PAD syndromes patients with SARS-CoV-2 mRNA vaccines

A new study posted to the medRxiv* preprint server has evaluated the effect of mRNA-based COVID-19 vaccination and boosting strategy on serum antibody responses in PAD patients against the original SARS-CoV-2 strain and circulating variants.

31 Jan 2022

Combined strategy suppresses the growth of deadly brain tumor

Short bursts of radiation therapy dramatically enhanced the efficiency of targeting glioblastomas with natural nanoparticle-based immunotherapy, thus suppressing growth of the deadly tumor, inducing anti-tumor immunity and prolonging survival in animal models, a research team at Massachusetts General Hospital has discovered.

31 Jan 2022

Yellow fever vaccine-vectored YF-S0 as a potent COVID-19 vaccine candidate

In a new study, a team of researchers developed YF-S0, an exceptionally potent COVID-19 vaccine candidate using live-attenuated yellow fever vaccine YF17D as a vector.

31 Jan 2022

Researchers assess outcomes of a self-care program for women with pelvic organ prolapse

University of Stirling researchers will explore the clinical and cost-effectiveness of an innovative self-management program designed to help improve the lives of women with pelvic organ prolapse.

31 Jan 2022

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

In a new study, a team of researchers discovered S-217622, a non-covalent SARS-CoV-2 3C-like protease (3CLpro) inhibitor clinical candidate for the treatment of COVID-19.

31 Jan 2022

Three exposures to SARS-CoV-2 spike protein can induce robust neutralizing antibodies against variants

In a new study, scientists revealed that three consecutive exposures SARS-CoV-2 spike protein through infection, vaccination, or both can induce strong neutralizing antibodies against a wide variety of viral variants, including omicron.

31 Jan 2022

How many lives would vaccine sharing have saved?

In a new study, researchers have been investigating different COVID-19 vaccine sharing simulations, and how they would affect affect global mortality.

31 Jan 2022

Protection provided to children through parental vaccination with the BNT162b2 vaccine

In a new study published in Science, scientists estimated the protection provided to children by means of parental vaccination with the BNT162b2 vaccine.

31 Jan 2022

Vaccine hypersensitivity in children

A new paper published in Pediatric Allergy and Immunity provides a useful overview of such reactions in relation to pediatric vaccines.

31 Jan 2022

A substrate envelope approach to examine drug resistance potential of SARS-CoV-2 Mpro

A team of scientists from the United States has recently defined the substrate envelop of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The study is currently available on the bioRxiv* preprint server while awaiting peer review.

31 Jan 2022

Children and adolescents respond as well or better than adults to mRNA-1273 COVID vaccination

A recent study assesses the neutralization efficacy of the mRNA-1273 vaccine against the SARS-CoV-2 Omicron variant in children, adolescents, and adults.

30 Jan 2022

Efficacy News and Research

New nanoparticle SARS-CoV-2 vaccine shows stronger, broader, and more durable protection

COVID-19 vaccines induce robust cellular immune response against SARS-CoV-2 Omicron

Study finds that high-dose convalescent plasma does not improve outcomes for severe COVID-19

High levels of neutralizing antibodies against Omicron after BNT162b2 booster vaccination

C-Path and EJP RD collaborate to expand global rare disease research and drug development

Neural stem cells plus HER2 inhibitor drug improve survival in mice with metastatic cancer

Assessing the effects of booster vaccinations against SARS-CoV-2 Omicron variant

Assessing the neutralizing ability of polyclonal antibody XAV-19 against SARS-CoV-2 Omicron variant

Study shows mRNA booster dose eliminates immune escape observed with SARS-CoV-2 Omicron

Study highlights importance of immunizing and boosting PAD syndromes patients with SARS-CoV-2 mRNA vaccines

Combined strategy suppresses the growth of deadly brain tumor

Yellow fever vaccine-vectored YF-S0 as a potent COVID-19 vaccine candidate

Researchers assess outcomes of a self-care program for women with pelvic organ prolapse

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

Three exposures to SARS-CoV-2 spike protein can induce robust neutralizing antibodies against variants

How many lives would vaccine sharing have saved?

Protection provided to children through parental vaccination with the BNT162b2 vaccine

Vaccine hypersensitivity in children

A substrate envelope approach to examine drug resistance potential of SARS-CoV-2 Mpro

Children and adolescents respond as well or better than adults to mRNA-1273 COVID vaccination

Industry Focus eBook - Cell biology (5th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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