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Study reveals multiple characteristics of HIV-1-producing cells in vivo

For eradication of HIV-1 infection, it is important to elucidate the detailed features and heterogeneity of HIV-1-infected cells in vivo.

29 Jul 2020

Deep learning algorithm can identify genetic alterations from routine histological images of tumors

Researchers at the University of Chicago Medicine Comprehensive Cancer Center, working with colleagues in Europe, created a deep learning algorithm that can infer molecular alterations directly from routine histology images across multiple common tumor types.

28 Jul 2020

'Synthetic lethality' could be exploited for cancer therapy

A Ludwig Cancer Research study has identified a new instance in which the simultaneous mutation of two nonessential genes--neither of which is on its own vital to cell survival--can cause cancer cell death.

28 Jul 2020

Evolutionary origins of SARS-CoV-2 identified

By reconstructing the evolutionary history of SARS-CoV-2, the virus that is responsible for the COVID-19 pandemic, an international research team of Chinese, European and U.S. scientists has discovered that the lineage that gave rise to the virus has been circulating in bats for decades and likely includes other viruses with the ability to infect humans.

28 Jul 2020

Human genome may explain the neonatal origins of chronic immune and inflammatory diseases

A study published in the journal Nature Communications has pinpointed a number of areas of the human genome that may help explain the neonatal origins of chronic immune and inflammatory diseases of later life, including type 1 diabetes, rheumatoid arthritis and coeliac disease.

28 Jul 2020

Simultaneous mutation of two nonessential genes can cause cancer cell death

A Ludwig Cancer Research study has identified a new instance in which the simultaneous mutation of two nonessential genes - neither of which is on its own vital to cell survival - can cause cancer cell death.

28 Jul 2020

Exploiting 'synthetic lethality' to identify cancer targets

With advances in genome sequencing, cancer treatments have increasingly sought to leverage the idea of "synthetic lethality," exploiting cancer-specific genetic defects to identify targets that are uniquely essential to the survival of cancer cells.

28 Jul 2020

New strategy may help guard beta cells, slow the onset of type 1 diabetes

Type 1 diabetes occurs when a person's own immune system destroys insulin-producing beta cells in the pancreas. In recent years, scientists have learned how to grow large volumes of replacement beta cells, but the researchers are still trying out many options to protect these cells against the immune attack.

27 Jul 2020

EBV viral genome alters the host epigenetic landscape to drive stomach cancer

The Epstein-Barr virus (EBV), one of the most common human viruses, is associated with about 8-10 per cent of stomach -- or gastric -- cancers, the third leading cause of cancer death globally.

27 Jul 2020

Study reveals manifold applications of cytokine transcriptional response modules in COVID-19

In a recent bioRxiv* study, UK researchers used interleukin modules to investigate the pathology of coronavirus disease (COVID-19).

27 Jul 2020

Researchers discover new method to treat herpes viruses

Researchers at Lund University in Sweden have discovered a new method to treat human herpes viruses. The new broad-spectrum method targets physical properties in the genome of the virus rather than viral proteins, which have previously been targeted.

24 Jul 2020

Neurotransmitter-derived lipidoids help carry drugs across the blood-brain barrier in mice

Biomedical engineers at the Tufts University School of Engineering have developed tiny lipid-based nanoparticles that incorporate neurotranmitters to help carry drugs, large molecules, and even gene editing proteins across the blood-brain barrier and into the brain in mice.

24 Jul 2020

Olympus and Cytosurge collaborate to deliver a complete single-cell and CRISPR genetic manipulation solution in the Americas

Olympus, a leading manufacturer of high-end research microscopes, and Cytosurge, a precision manufacturer of cell manipulation technologies, have entered a co-marketing agreement to become a complete system provider to the scientific community’s growing need for next-generation single-cell and CRISPR genetic manipulation solutions.

From Evident Corporation - Life Sciences 24 Jul 2020

New genome-editing technologies can help understand disease-associated genetic mutations

New genome-editing technologies developed by researchers in J. Keith Joung's laboratory at the Massachusetts General Hospital (MGH) have the potential to help understand disease-associated genetic mutations that are based on C-to-G (cytosine to guanine) single base changes.

24 Jul 2020

Epigenomic modifications play key role in the development of lung tumors

As cancer cells evolve, many of their genes become overactive while others are turned down. These genetic changes can help tumors grow out of control and become more aggressive, adapt to changing conditions, and eventually lead the tumor to metastasize and spread elsewhere in the body.

23 Jul 2020

New strategy allows long-term, non-invasive tracking of cardiomyocytes

A new platform reported on today in STEM CELLS Translational Medicine (SCTM) will enable long-term tracking of cardiomyocytes produced from induced pluripotent stem cells (iPSCs) after implantation into the heart.

23 Jul 2020

Study shows interferons do not induce the expression of SARS-CoV-2 cell entry receptor

In a new bioRxiv study, authors identified a isoform of ACE2 (designated as deltaACE2 or dACE2) receptor, shown to be induced in various human cell types.

23 Jul 2020

Amyloid plaques may act as trigger for Alzheimer's disease

The brains of people living with Alzheimer's are riddled with plaques: protein aggregates consisting mainly of amyloid-beta.

23 Jul 2020

Ashion Analytics and Elevation Oncology form innovative cancer treatment partnership

Ashion Analytics LLC today announced a partnership with Elevation Oncology, a clinical stage biopharmaceutical company, focused on the matching of patients with tumors harboring an NRG1 gene fusion identified using Ashion's proprietary GEM ExTra test with CRESTONE, a registration-directed Phase 2 study sponsored by Elevation Oncology.

23 Jul 2020

Vesigen Therapeutics to develop and commercialize novel drug-delivery technologies

Harvard University's Office of Technology Development (OTD) and the Harvard T.H. Chan School of Public Health today announced the launch of Vesigen Therapeutics, a startup company that aims to overcome the challenge of delivering next-generation therapeutics, such as gene-editing complexes, RNA molecules, and other large proteins, to intracellular targets in specific tissues of interest.

23 Jul 2020

Genome News and Research

Study reveals multiple characteristics of HIV-1-producing cells in vivo

Deep learning algorithm can identify genetic alterations from routine histological images of tumors

'Synthetic lethality' could be exploited for cancer therapy

Evolutionary origins of SARS-CoV-2 identified

Human genome may explain the neonatal origins of chronic immune and inflammatory diseases

Simultaneous mutation of two nonessential genes can cause cancer cell death

Exploiting 'synthetic lethality' to identify cancer targets

New strategy may help guard beta cells, slow the onset of type 1 diabetes

EBV viral genome alters the host epigenetic landscape to drive stomach cancer

Study reveals manifold applications of cytokine transcriptional response modules in COVID-19

Researchers discover new method to treat herpes viruses

Neurotransmitter-derived lipidoids help carry drugs across the blood-brain barrier in mice

Olympus and Cytosurge collaborate to deliver a complete single-cell and CRISPR genetic manipulation solution in the Americas

New genome-editing technologies can help understand disease-associated genetic mutations

Epigenomic modifications play key role in the development of lung tumors

New strategy allows long-term, non-invasive tracking of cardiomyocytes

Study shows interferons do not induce the expression of SARS-CoV-2 cell entry receptor

Amyloid plaques may act as trigger for Alzheimer's disease

Ashion Analytics and Elevation Oncology form innovative cancer treatment partnership

Vesigen Therapeutics to develop and commercialize novel drug-delivery technologies

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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