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Scientists identify on/off obesity-induced switch to slow cancer progression

Having established that excessive fat tissue can fuel the growth of certain cancers, researchers have turned their attention to the molecular mechanisms involved in the process in the hopes of developing new cancer treatments.

21 Jun 2016

Study shows childhood adversities, sleep disturbances interfere with immune system regulation

Adverse childhood experiences and sleep disturbances interfere with immune system regulation, shows research from the University of Eastern Finland.

20 Jun 2016

Scientists identify lipodystrophy-causing mutation in a single family

Lipodystrophy syndromes are characterized by an abnormal distribution of adipose tissue and metabolic dysfunction. These disorders are rare and the underlying genetic abnormalities that lead to altered fat distribution are not fully known.

16 Jun 2016

CT-derived SULps can improve accuracy of PET imaging in advanced cancer patients

Cancer patients often experience significant fluctuations in weight and lean body mass (LBM). Neglecting to account for these changes can prevent clinicians from obtaining precise data from molecular imaging, but a new method of measuring LBM takes changes in individual body composition into account for better staging of disease and therapy monitoring, say researchers at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging.

15 Jun 2016

Study shows subcutaneous fat tissue has internal clock that regulates insulin sensitivity

Fat tissue shows a robust circadian rhythm in a dish.In humans, glucose tolerance varies with time of day, but the mechanism responsible for the variation in insulin sensitivity throughout the day is unclear.

8 Jun 2016

New technique helps identify link between fatty acids and breast cancer in postmenopausal women

The presence of high saturated fatty acids in breast tissue may be a useful indicator of cancer in postmenopausal women, according to a new study by researchers at NYU Langone Medical Center, published online June 7 in Radiology, a journal of the Radiological Society of North America.

7 Jun 2016

Study establishes copper’s role in fat metabolism

A new study is further burnishing copper's reputation as an essential nutrient for human physiology. A research team led by a scientist at the Department of Energy's Lawrence Berkeley National Laboratory and at the University of California, Berkeley, has found that copper plays a key role in metabolizing fat.

7 Jun 2016

Epigenomic alterations play key role in triggering obesity-induced diabetes

Obesity is a risk factor for developing type 2 diabetes, yet not all obese humans develop the disease. In a new study, researchers from the Karolinska Institutet in Sweden and from the Institute of Health and Medical Research in France have identified epigenomic alterations that are associated with inflammation and type 2 diabetes

7 Jun 2016

Severe obesity may contribute to infection risk after bypass surgery

Severely obese patients who undergo a coronary artery bypass are more likely to develop an infection after surgery and stay in hospital longer, compared with people of normal weight, according to a study published in the Journal of the American Heart Association.

2 Jun 2016

Scientists take key step towards understanding link between obesity and physically distant diseases

Obesity is on the rise throughout the world, and in some developed countries two-third of the adult population is either overweight or obese. This brings with it an increased risk of serious conditions such as heart disease, stroke, cancer and osteoarthritis.

23 May 2016

TAK1 deficit protects mice from obesity

Obesity and subsequent complications are increasing in frequency worldwide. The accumulation of adipose tissue is associated with increased inflammation, and it has been proposed that modification of proinflammatory responses could alter adipose tissue composition.

20 May 2016

Exercise plays significant role in combating obesity

Two factors—metabolism and gut microbes - have been credited by researchers as key players in the fight against obesity.

17 May 2016

New nanoparticle approach can deliver antiobesity drugs directly to fat tissue

Researchers at MIT and Brigham and Women's Hospital have developed nanoparticles that can deliver antiobesity drugs directly to fat tissue. Overweight mice treated with these nanoparticles lost 10 percent of their body weight over 25 days, without showing any negative side effects.

3 May 2016

Transforming MR images into body composition measurements: an interview with Olof Leinhard

Today's medical science utilizes relatively simple anthropometric measures that describe the body, such as body mass index (BMI) and waist circumference. All of these measures are approximations of the body with the intention to characterize what's inside reflecting underlying phenomena that underpin the risk for different diseases.

26 Apr 2016

Pluristem granted two key cell therapy patents in Japan

Pluristem Therapeutics Inc. (PSTI), a leading developer of placenta-based cell therapy products, has announced that the Japan Patent Office has granted the Company two key patents addressing...

14 Apr 2016

Joslin scientists identify new mechanism in development of obesity-induced insulin resistance

In obesity, the body's immune system can treat tissues as if they are suffering from a low-grade chronic infection. This obesity-induced inflammation is an important contributor to insulin resistance, a condition that can progress into type 2 diabetes.

2 Apr 2016

Gleevec could be novel therapeutic agent for type 2 diabetes

The cancer treatment drug Imatinib, otherwise known as Gleevec is approved to treat various forms of cancer, mostly notably chronic myeloid leukemia (CML). However, researchers have stumbled onto another possible use for it, curing type 2 diabetes.

28 Mar 2016

MicroRNA can help combat obesity and diabetes

Obesity, which is associated with low-grade inflammation, is an important contributor in the development of diabetes and cardiovascular disease. While the role of several organs including adipose tissue have been implicated in this process, the cell types and factors driving this process have not been clear.

16 Mar 2016

Excessive fat accumulation in lower extremities of children linked to insulin resistance, metabolic disorders

Children with a severe type of spina bifida called myelomeningocele have a high prevalence of obesity and excess fat accumulation in their lower extremities. In a study designed to assess bone, muscle and fat tissue distribution in the lower legs of children with this disease, researchers at Children's Hospital Los Angeles determined that this excess fat tissue is within the muscle boundary (muscle-associated) rather than subcutaneous.

15 Mar 2016

TRPV2 could be a target for obesity therapy

Brown adipose tissue (BAT), a major site for mammalian non-shivering thermogenesis, could be a target for prevention and treatment of human obesity. Transient receptor potential vanilloid 2 (TRPV2), a Ca2+-permeable cation channel, plays vital roles in the regulation of various cellular functions.

14 Mar 2016

Adipose News and Research

Scientists identify on/off obesity-induced switch to slow cancer progression

Study shows childhood adversities, sleep disturbances interfere with immune system regulation

Scientists identify lipodystrophy-causing mutation in a single family

CT-derived SULps can improve accuracy of PET imaging in advanced cancer patients

Study shows subcutaneous fat tissue has internal clock that regulates insulin sensitivity

New technique helps identify link between fatty acids and breast cancer in postmenopausal women

Study establishes copper’s role in fat metabolism

Epigenomic alterations play key role in triggering obesity-induced diabetes

Severe obesity may contribute to infection risk after bypass surgery

Scientists take key step towards understanding link between obesity and physically distant diseases

TAK1 deficit protects mice from obesity

Exercise plays significant role in combating obesity

New nanoparticle approach can deliver antiobesity drugs directly to fat tissue

Transforming MR images into body composition measurements: an interview with Olof Leinhard

Pluristem granted two key cell therapy patents in Japan

Joslin scientists identify new mechanism in development of obesity-induced insulin resistance

Gleevec could be novel therapeutic agent for type 2 diabetes

MicroRNA can help combat obesity and diabetes

Excessive fat accumulation in lower extremities of children linked to insulin resistance, metabolic disorders

TRPV2 could be a target for obesity therapy

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