Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Liver's defense mechanism hinders immunity in chronic hepatitis B, study reveals

In chronic hepatitis B, the liver contains immune cells that could destroy hepatitis B virus infected cells but are inactive. A team from the Technical University of Munich (TUM) has discovered that cells blood vessels in the liver start a "sleep timer" that switches off immune cells. Targeting this mechanism could be a starting point for immunotherapies.

11 Jul 2024

Existing drug shows promise for treating common liver disease

The University of Barcelona has led a study that suggests using the drug known as pemafibrate to treat liver disease associated with metabolic disorders, the most common liver pathology in the world, which affects one in four people. The drug has long been marketed in Japan for another use: improving blood lipid levels in patients with hyperlipidaemia, a common condition in diabetics. Now, however, it could help address this serious liver disease, which still has no specific treatment.

11 Jul 2024

Aging aggravates liver fibrosis in Down Syndrome, new study finds

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 12, entitled, "Aging exacerbates oxidative stress and liver fibrosis in an animal model of Down Syndrome."

10 Jul 2024

Repurposing pemafibrate to treat liver disease associated with metabolic disorders

10 Jul 2024

Researchers uncover the incidence and prevalence of eosinophilic esophagitis in Japan

In one of the first studies of its kind in Japan, Osaka Metropolitan University-led researchers uncovered the incidence and prevalence of the chronic allergic disorder eosinophilic esophagitis, or EoE.

10 Jul 2024

Blocking nidogen-2 enhances chemotherapy efficacy in pancreatic cancer

Researchers at the Garvan Institute of Medical Research have identified a potential new therapeutic target for pancreatic cancer, one of the most lethal cancer types with limited treatment options.

9 Jul 2024

Smartphone-based behavioral therapy leads to improvements for patients with fibromyalgia

New research led by the University of Cincinnati and Swing Therapeutics found that a self-guided smartphone-based behavioral therapy led to significant improvements for patients with fibromyalgia.

8 Jul 2024

Small molecule discovery offers hope for treatment of Angelman syndrome

Angelman syndrome is a rare genetic disorder caused by mutations in the maternally-inherited UBE3A gene and characterized by poor muscle control, limited speech, epilepsy, and intellectual disabilities.

8 Jul 2024

Phages use selfish DNA to outmaneuver competitors

Curious bits of DNA tucked inside genomes across all kingdoms of life historically have been disregarded since they don't seem to have a role to play in the competition for survival.

5 Jul 2024

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, has successfully delivered the second preclinical candidate compound (PCC) in its collaboration with Fosun Pharma in June 2024, a potential innovative therapeutic using synthetic lethal strategy for the treatment of solid tumors.

5 Jul 2024

Senolytic drugs are not a "one-size-fits-all" remedy and may benefit some older women

Drugs that selectively kill senescent cells may benefit otherwise healthy older women but are not a "one-size-fits-all" remedy, Mayo Clinic researchers have found.

2 Jul 2024

Regulatory T cells exist as large, mobile population that travels through body to repair damaged tissue

Researchers investigated populations of regulatory T cells, a type of white blood cell, in various tissues.

1 Jul 2024

A unifying marker streamlines macrophage research across age and sex

Macrophages play a critical role in the immune system by fighting infections and aiding in tissue repair. Understanding how these cells are activated in different scenarios is important for developing new medical treatments. However, identifying and studying macrophage activation has been challenging due to the complex nature of these cells and their responses.

27 Jun 2024

CSF1R marker enables study of Macrophage Activation Mosaicism

Macrophages play a critical role in the immune system by fighting infections and aiding in tissue repair.

26 Jun 2024

Pentraxin 3 as a predictor of advanced fibrosis and carotid intima-media thickness in MAFLD patients

Metabolic-associated fatty liver disease (MAFLD) may increase the risk of cardiovascular events. In this study, we assessed the predictive value of pentraxin 3 (PTX3) for severe fibrosis and carotid intima-media thickness (CIMT) in patients with MAFLD.

25 Jun 2024

Integrated cellular map of heart cells unlocks cardiac fibrosis process

Scientists at the Victor Chang Cardiac Research Institute in Australia have produced a first of its kind integrated map of heart cells which unlocks the process of cardiac fibrosis – a major cause of heart failure.

21 Jun 2024

Insilico Medicine leadership team shares insights on AI-powered healthcare innovation

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, announces that the co-CEOs of the company – Alex Zhavoronkov, PhD, and Feng Ren, PhD – will be attending the 15th Annual Meeting of the New Champions, also known as Summer Davos hosted by the World Economic Forum, in Dalian, China, from 25 to 27 June 2024.

21 Jun 2024

Fibrosis News and Research

Further Reading

Liver's defense mechanism hinders immunity in chronic hepatitis B, study reveals

Existing drug shows promise for treating common liver disease

Aging aggravates liver fibrosis in Down Syndrome, new study finds

Repurposing pemafibrate to treat liver disease associated with metabolic disorders

Researchers uncover the incidence and prevalence of eosinophilic esophagitis in Japan

Blocking nidogen-2 enhances chemotherapy efficacy in pancreatic cancer

Smartphone-based behavioral therapy leads to improvements for patients with fibromyalgia

Small molecule discovery offers hope for treatment of Angelman syndrome

Phages use selfish DNA to outmaneuver competitors

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Senolytic drugs are not a "one-size-fits-all" remedy and may benefit some older women

Regulatory T cells exist as large, mobile population that travels through body to repair damaged tissue

A unifying marker streamlines macrophage research across age and sex

CSF1R marker enables study of Macrophage Activation Mosaicism

Pentraxin 3 as a predictor of advanced fibrosis and carotid intima-media thickness in MAFLD patients

Integrated cellular map of heart cells unlocks cardiac fibrosis process

Insilico Medicine leadership team shares insights on AI-powered healthcare innovation

Safety-focused summary of GLP-1 receptor agonists in diabetes, obesity, and beyond

Enterprise Therapeutics appoints Dr Renu Gupta as Chief Medical Officer and Dr Janet Hammond as Non-Executive Director

Short-term alcohol abstinence worsens gut health in alcohol use disorder patients

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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