Neurodegenerative Diseases News and Research

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PQBP3 protein found to play key role in aging and brain disorders

In a recent study published online on August 5 2024 in The EMBO Journal, researchers from Tokyo Medical and Dental University (TMDU) in Japan have uncovered a crucial piece of this puzzle by focusing on the role of a single nucleolar protein.

3 Sep 2024

Matcha green tea enhances cognition and sleep in older adults

Regular matcha green tea consumption may improve emotional perception and sleep quality in older adults with cognitive decline, though it shows no significant effect on broader cognitive functions.

2 Sep 2024

NCCS study uses exosomes to overcome resistance to epidermal growth factor receptor inhibitors

In a new study, clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS) have demonstrated the use of exosomes to successfully target squamous cell cancer tumours that are usually resistant to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). Their research is the first where exosomes have been applied to target TKI-resistant cancers in Singapore. The findings were published in the journal Developmental Cell last month.

2 Sep 2024

Redefining 5hmC: More than just a stepping stone in the DNA demethylation pathway

An important DNA modification is methylation, or the addition of a methyl group to the 5th carbon of cytosine. This forms 5-methylcytosine (5mC), typically associated with repression of gene expression.

From biomodal 30 Aug 2024

Environmental and social factors impact brain aging, study shows

Your brain ages at different paces according to social and physical environments in aging and dementia.

29 Aug 2024

PET imaging and proteomics reveal distinct protein signatures in Alzheimer's disease progression

Researchers used PET imaging and proteomic analysis of cerebrospinal fluid to study amyloid β and tau tangle loads in Alzheimer's patients, identifying 127 proteins linked to disease progression. The findings highlight distinct molecular pathways and potential therapeutic targets.

28 Aug 2024

SCARB2 deficiency disrupts bile acid metabolism and gut microbiome

The study details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid metabolism and dysbiosis in the gut microbiome. This disruption affects the signaling pathway involving FXR, which normally regulates bile acid synthesis and intestinal lipid absorption. The hyperactive FXR in Scarb2-deficient mice leads to a decrease in epithelial cell turnover and lipid malabsorption, particularly impacting the absorption of vitamin E, which is crucial for maintaining neurological health. The researchers further explored the impact of these changes on the gut-liver axis and found alterations in the expression of genes related to bile acid synthesis.

23 Aug 2024

Cancer drug holds promise as a new treatment for neurodegenerative diseases

A type of drug developed for treating cancer holds promise as a new treatment for neurodegenerative diseases such as Alzheimer's, according to a recent study by researchers at Penn State, Stanford University and an international team of collaborators.

22 Aug 2024

Breakthrough compound targets appetite and tau protein in obesity and Alzheimer's

Scientists on the team of Dr Lenka Maletínská have developed a promising new compound derived from one of the peptides naturally occurring in the brain.

21 Aug 2024

The role of the gut microbiota in multiple sclerosis: A scientometric analysis reveals key research trends

Researchers examine the relationship between gut microbiota and multiple sclerosis.

21 Aug 2024

AI-powered Surreal-GAN identifies diverse brain aging patterns

Researchers utilize ‘Surreal-GAN,’ a deep-representation learning model, to examine the heterogeneity of aging brains.

20 Aug 2024

Study highlights LLPS's influence on signaling pathways and disease progression

This paper, led by Professor Wu (Wenzhou Institute University, Wenzhou Medical University) and Professor Huang (Northeastern University), explores LLPS, a phenomenon closely associated with various diseases, including cancer and neurodegenerative disorders.

16 Aug 2024

Infections drive brain volume loss and dementia risk by altering key immune proteins, study reveals

Severe infections are linked to increased brain atrophy, particularly in the temporal lobe, which may elevate dementia risk through immune-related proteins.

15 Aug 2024

Researchers reveal why a diet rich in magnesium is so important for your health

Researchers examined whether magnesium deficiency in the healthy middle-aged Australian population was independently or in combination with increased homocysteine levels associated with in vivo DNA damage.

15 Aug 2024

Researchers develop new method to study critical type of protein modification process

Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability.

12 Aug 2024

New histone tag discovery offers hope for myelin repair in neurodegenerative diseases

In a groundbreaking study, researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have identified a distinct histone tag in adult oligodendrocyte progenitor cells (OPCs) that may pave the way for innovative therapies targeting myelin repair, a critical target for several neurodegenerative and psychiatric disorders, including multiple sclerosis, Alzheimer's disease, and schizophrenia.

12 Aug 2024

New study links brain cell structures to memory loss in aging and dementia

Researchers assessed whether dendritic spine head diameter in the temporal cortex is a better predictor of episodic memory performance in older adults than synapse quantity, accounting for β amyloid plaques, neurofibrillary tangles, and sex.

12 Aug 2024

ATP regulation in ClC-3 exchangers linked to neurodegenerative diseases, study reveals

Researchers structurally analyzed adenine nucleotide control and neurodegenerative diseases in ClC-3 exchangers.

11 Aug 2024

C-Path supports innovative ALS, neurodegenerative disease research with new grant

Critical Path Institute's (C-Path) Translational Therapeutics Accelerator (TRxA) announced today a new research grant awarded to Daniela C. Zarnescu, Ph.D., Professor of Cellular and Molecular Physiology at Penn State University College of Medicine, in collaboration with Jon Njardarson, Ph.D., Professor at the University of Arizona.

8 Aug 2024

Cap-QuIC: A new visual diagnostic technique for early detection of neurodegenerative diseases

Researchers at the University of Minnesota, have developed a new visual diagnostic technique that can be used to advance early detection for neurodegenerative diseases like Parkinson's disease and similar diseases that affect animals, including Chronic Wasting Disease in deer.

6 Aug 2024

Neurodegenerative Diseases News and Research

PQBP3 protein found to play key role in aging and brain disorders

Matcha green tea enhances cognition and sleep in older adults

NCCS study uses exosomes to overcome resistance to epidermal growth factor receptor inhibitors

Redefining 5hmC: More than just a stepping stone in the DNA demethylation pathway

Environmental and social factors impact brain aging, study shows

PET imaging and proteomics reveal distinct protein signatures in Alzheimer's disease progression

SCARB2 deficiency disrupts bile acid metabolism and gut microbiome

Cancer drug holds promise as a new treatment for neurodegenerative diseases

Breakthrough compound targets appetite and tau protein in obesity and Alzheimer's

The role of the gut microbiota in multiple sclerosis: A scientometric analysis reveals key research trends

AI-powered Surreal-GAN identifies diverse brain aging patterns

Study highlights LLPS's influence on signaling pathways and disease progression

Infections drive brain volume loss and dementia risk by altering key immune proteins, study reveals

Researchers reveal why a diet rich in magnesium is so important for your health

Researchers develop new method to study critical type of protein modification process

New histone tag discovery offers hope for myelin repair in neurodegenerative diseases

New study links brain cell structures to memory loss in aging and dementia

ATP regulation in ClC-3 exchangers linked to neurodegenerative diseases, study reveals

C-Path supports innovative ALS, neurodegenerative disease research with new grant

Cap-QuIC: A new visual diagnostic technique for early detection of neurodegenerative diseases

eBook: Using iPSCs models for human disease research and drug discovery eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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