Polymerase Chain Reaction News and Research

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Polymerase chain reaction (PCR) is a revolutionary laboratory technique that enables the replication of a specific DNA sequence. Using PCR, millions of copies of a target DNA can be easily synthesized within a short period of time.

Study finds community-onset bacterial coinfection in children with critical COVID-19 is infrequent but empiric antibiotics are commonly prescribed

Researchers evaluated the use of empiric antibiotics to determine the prevalence rates of community-acquired bacterial coinfections among hospitalized pediatric critical COVID-19 patients.

8 Mar 2023

Prevalence and clinical outcomes of viral and bacterial coinfections in hospitalized COVID-19 patients

In a recent study, researchers analyzed the occurrence of bacterial and viral infections in adults hospitalized with coronavirus disease 2019 (COVID-19) to determine the clinical and demographic features, outcomes, and microbial spectrums associated with bacterial coinfections and the prevalence of viral coinfections.

7 Mar 2023

Effectiveness of monovalent COVID-19 mRNA booster vaccination vs. two-dose primary series during Omicron variant circulation

Researchers estimated the immune protection conferred by monovalent-type COVID-19 mRNA booster doses vs. two-dose prime vaccination series during SARS-CoV-2 Omicron variant predominance in community settings.

7 Mar 2023

Zoo study: SARS-CoV-2 surveillance across all mammal species

Researchers from Belgium conduct SARS-CoV-2 surveillance among all mammal species found in two zoos.

6 Mar 2023

Meta-analysis on COVID-19 vaccine effectiveness in association with antibody titers

Researchers performed a meta-analysis analyzing randomized controlled trials (RCTs) that evaluated the effectiveness of coronavirus disease 2019 (COVID-19) vaccines, and the dose-response association of humoral responses with vaccine effectiveness.

6 Mar 2023

Naked mRNA delivered using needle-free PYRO injection presents a safe and effective potential vaccination method

Researchers examined the vaccination effects and local antigen expression efficiency of a needle-free vaccination technique involving pyro-drive liquid jet injection (PYRO) to deliver the naked messenger ribonucleic acid (mRNA) to the skin.

3 Mar 2023

Study identifies renalase as a novel independent predictor of COVID-19-related mortality

Researchers assessed the role of renalase as an independent predictor of COVID-19-related mortality.

2 Mar 2023

Role of phosphatidylinositol 3 kinase pathway in corneal damage due to blue light exposure

Researchers observe corneal damage by blue light exposure is due to PI3K/AKT pathway inhibition.

1 Mar 2023

SARS-CoV-2 BA.1 and BA.2 breakthrough infections likely protect against BA.4 infection

Omicron BTIs induce durable neutralizing immune responses by recalling cross-reactive and vaccine-induced memory B lymphocytes.

1 Mar 2023

Research investigates roles of neurotrophic factors on cognition in Alzheimer's patients carrying APOE ε4

Researchers investigate the role of neurotrophic factors on the cognitive performance of Alzheimer’s disease patients carrying the apolipoprotein E 4 gene.

1 Mar 2023

Evidence that cross-reactive immunity from common human coronaviruses can influence response to SARS-CoV-2

In a recent study published in the journal Vaccines, researchers in Saudi Arabia and the United States examined immune responses and immunoglobulin G (IgG) cross-reactivity in individuals infected with Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

28 Feb 2023

25% of COVID-19 patients have lasting reduction in lung function

In a recent study posted to the Preprints with The Lancet SSRN* server, researchers evaluated the impairment of pulmonary function in individuals suffering from post-acute sequelae of coronavirus disease 2019 (COVID-19) (PASC) or long coronavirus disease (long COVID) symptoms after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

28 Feb 2023

Mass spectrometry-based identification of COVID-19 biomarkers

In a recent study published in the journal Metabolites, researchers reported that mass spectrometry (MS)-based metabolomic approaches have a high potential for biomarker discovery.

28 Feb 2023

The effects of Omicron emergence on seroprevalence and hybrid immunity in the Finnish adult population

Researchers evaluated SARS-CoV-2 seroprevalence and population-level humoral immunity among Finnish individuals between April 2020 and December 2022.

28 Feb 2023

COVID-19 does not increase the risk of Streptococcus pneumoniae infection

SARS-CoV-2 infection does not appear to influence pneumococcal colonization in the upper respiratory tract.

28 Feb 2023

Critical COVID-19 infection characterized by a shift from naïve T cell phenotypes to an expansion of cytotoxic CD4+ T lymphocyte subsets

Researchers immunophenotyped T lymphocyte responses among unvaccinated individuals, representative of the entire spectrum of the clinical presentation of COVID-19.

28 Feb 2023

COVID-19 increases risk of developing chronic diseases

Researchers determine the correlation between severity of SARS-CoV-2 infection, age, and new onset of chronic or worsening of pre-existing conditions.

28 Feb 2023

The evolution of transmissible variants harboring mutations consistent with immune escape in mild community COVID-19 cases

Researchers investigate whether transmissible SARS-CoV-2 variants developed during infection by culturing and sequencing strains obtained from serial oral and nasal samples of community-residing COVID-19 patients.

28 Feb 2023

Innovative methodology to detect viral RNA

Experts from the University of Barcelona, the Institute for Advanced Chemistry of Catalonia, the Institute of Microelectronics of Barcelona and the Aragon Nanoscience and Materials Institute of Aragon —a joint institute of the CSIC and the University of Zaragoza— have developed a new method to detect RNA viruses based on the triplex-forming probe technology.

27 Feb 2023

Does a negative COVID-19 test before air travel reduce the spread of COVID-19 transmission during and after travel?

Researchers assessed the impact of pre-departure testing on SARS-CoV-2-positivity rates post-arrival among international travelers.

27 Feb 2023

Polymerase Chain Reaction News and Research

Further Reading

Study finds community-onset bacterial coinfection in children with critical COVID-19 is infrequent but empiric antibiotics are commonly prescribed

Prevalence and clinical outcomes of viral and bacterial coinfections in hospitalized COVID-19 patients

Effectiveness of monovalent COVID-19 mRNA booster vaccination vs. two-dose primary series during Omicron variant circulation

Zoo study: SARS-CoV-2 surveillance across all mammal species

Meta-analysis on COVID-19 vaccine effectiveness in association with antibody titers

Naked mRNA delivered using needle-free PYRO injection presents a safe and effective potential vaccination method

Study identifies renalase as a novel independent predictor of COVID-19-related mortality

Role of phosphatidylinositol 3 kinase pathway in corneal damage due to blue light exposure

SARS-CoV-2 BA.1 and BA.2 breakthrough infections likely protect against BA.4 infection

Research investigates roles of neurotrophic factors on cognition in Alzheimer's patients carrying APOE ε4

Evidence that cross-reactive immunity from common human coronaviruses can influence response to SARS-CoV-2

25% of COVID-19 patients have lasting reduction in lung function

Mass spectrometry-based identification of COVID-19 biomarkers

The effects of Omicron emergence on seroprevalence and hybrid immunity in the Finnish adult population

COVID-19 does not increase the risk of Streptococcus pneumoniae infection

Critical COVID-19 infection characterized by a shift from naïve T cell phenotypes to an expansion of cytotoxic CD4+ T lymphocyte subsets

COVID-19 increases risk of developing chronic diseases

The evolution of transmissible variants harboring mutations consistent with immune escape in mild community COVID-19 cases

Innovative methodology to detect viral RNA

Does a negative COVID-19 test before air travel reduce the spread of COVID-19 transmission during and after travel?

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