Biochemistry News and Research

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Targeting key proteins of carcinogenesis

Misfolded and disused proteins are eliminated by a cellular shredder called the proteasome.

23 Jun 2007

Genes play unexpected role in their own activation

Investigators at St. Jude Children's Research Hospital have discovered how a single molecular "on switch" triggers gene activity that might cause effects ranging from learning and memory capabilities to glucose production in the liver.

23 Jun 2007

Evolutionary dynamics of immune-related genes and pathways in disease vector mosquitoes

The genes that make up the immune system of the Aedes aegypti mosquito which transmits deadly viral diseases to humans have been identified in new research in Science.

23 Jun 2007

New cancer drug target

Research led by scientists at Weill Cornell Medical College has uncovered two new potential points of vulnerability on a key cancer-promoting protein, called XIAP.

23 Jun 2007

Study to investigate how dietary iron is used by cells

A four-year study on iron metabolism within cells, an essential process that impacts both iron deficiency and iron toxicity, conditions responsible for a multitude of human diseases, is underway at the University at Buffalo funded by a $1.16 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

23 Jun 2007

RNA polymerase points to new targets for drug design

Researchers at UAB (University of Alabama at Birmingham) have new information on the structure of a key enzyme in bacteria that could lead to improved antibiotics and less antibiotic resistance.

23 Jun 2007

New uderstanding of how enzymes work

In a publication selected as a "2007 Hot Article" by the journal Biochemistry , University at Buffalo chemists report the discovery of a central mechanism responsible for the action of the powerful biological catalysts known as enzymes.

20 Jun 2007

Do common treatments for ADHD increase risk of drug abuse?

Parents, doctors, and others have wondered whether common treatments for attention-deficit hyperactivity disorder (ADHD) inadvertently predispose adolescents to future drug abuse.

19 Jun 2007

New understanding of how the DNA helix replicates

A team of researchers led by University of Virginia Health System geneticists has uncovered a major secret in the mystery of how the DNA helix replicates itself time after time.

18 Jun 2007

Secrets of chromosome movement revealed

Investigators at St. Jude Children's Research Hospital have used the lowly yeast to gain insights into how a dividing human cell ensures that an identical set of chromosomes gets passed on to each new daughter cell.

17 Jun 2007

New drug-delivery system using nanomaterials

Researchers at UCLA have successfully manipulated nanomaterials to create a new drug-delivery system that promises to solve the challenge of the poor water solubility of today's most promising anticancer drugs and thereby increase their effectiveness.

8 Jun 2007

New understanding of anti-malarial drug resistance

Researchers at Georgetown University Medical Center say they are moving closer to understanding why the most lethal form of human malaria has become resistant to drug treatment in the past three decades.

8 Jun 2007

HIV uses pathways to infect cells

Like hobos on a train, HIV, the virus that causes AIDS, uses a pre-existing transport system to leave one infected cell and infect new ones, Hopkins scientists have discovered.

8 Jun 2007

Mouse hibernation hormones described

A key hormone enables starving mice to alter their metabolism and “hibernate” to conserve energy, revealing a novel molecular target for drugs to treat human obesity and metabolic disorders, UT Southwestern Medical Center researchers have found.

8 Jun 2007

Gene therapy delivery of nerve growth factors reverses erectile dysfunction in mice

Rats with erectile dysfunction, or ED, that were injected with a gene therapy vector containing either of two nerve growth factors were able to regain normal function after four weeks, according to a study conducted by University of Pittsburgh School of Medicine researchers.

5 Jun 2007

World's first PET/MR images of the human brain

The world's first PET/MR images of the human brain, taken simultaneously by positron emission tomography (PET) imaging and magnetic resonance (MR), debuted during the 54th Annual Meeting of SNM, the world's largest society for molecular imaging and nuclear medicine professionals, June 2-6 in Washington, D.C.

From Siemens Healthineers 5 Jun 2007