UIC receives $9.6 million grant for autism research

The University of Illinois at Chicago has been awarded a $9.6 million, five-year grant from the National Institutes of Health to establish an Autism Center of Excellence.

UIC is one of five funded centers in the United States and the only Midwest site.

The UIC Autism Center of Excellence will be an interdisciplinary, translational program of research encompassing genetics, biochemistry, neurophysiology, neuroimaging and behavior. Researchers will investigate the underlying causes and potential treatment for a common problem related to autism known as insistence on sameness, or repetitive behavior.

"Problems related to repetitive behaviors, such as anxiety and aggression, are among the most troublesome and debilitating for individuals with autism and their families," said Dr. Edwin Cook, professor of psychiatry, director of the Laboratory of Developmental Neuroscience at UIC's Institute for Juvenile Research and director of the UIC Autism Center of Excellence.

Autism spectrum disorders affect about one in 160 individuals. People with autism often have difficulty communicating and forming relationships. Approximately one-third of people with autism have serious repetitive behavior problems, according to Cook. Disruption in rituals or routines for these children and adults can result in prolonged tantrums, screaming, violence or physical injury.

Previous research has shown that selective serotonin reuptake inhibitor medications, also known as SSRI drugs, are effective and can dramatically improve quality of life in some patients with repetitive behaviors and obsessive compulsive disorder.

"It's wonderful when we have patients who respond to medication and do well, but we have many patients who either do not respond, or only partially respond, and who end up with strong compulsions involving aggression," said Cook.

Three collaborative projects within the UIC Autism Center of Excellence will investigate the genetics of serotonin in autism, identify patients who best respond to SSRI treatment based on genetic markers, and use brain imaging and neurobehavioral studies to determine the effects of SSRI drugs before and after treatment.

"The goal of the center is to approach this vexing clinical problem from genetic, cognitive neuroscience and pharmacological approaches, across species, in an unusually integrated way," said Cook.

The center's particular focus on insistence on sameness, or repetitive behavior, will allow testing and development of new individualized treatments and optimization of available drug treatments to best complement behavioral interventions, according to Cook.

The UIC Autism Center of Excellence seeks families that have an individual with an autism spectrum disorder for a research study investigating brain disorders and the genetics of autism to participate in clinical research. For more information, visit www.psych.uic.edu/ldn/ACE_recruitment_flyer,_v3_07062007.pdf, e-mail [email protected] or call (312) 413-4624.

The project and core principal investigators funded under the UIC Autism Center of Excellence are Cook, John Sweeney, Michael Ragozzino, Thomas Owley, Robert Gibbons, Bennett Leventhal, and Jeff Salt at UIC; James Sutcliffe at Vanderbilt University; and Nancy Cox at the University of Chicago.

UIC ranks among the nation's top 50 universities in federal research funding and is Chicago's largest university with 25,000 students, 12,000 faculty and staff, 15 colleges and the state's major public medical center. A hallmark of the campus is the Great Cities Commitment, through which UIC faculty, students and staff engage with community, corporate, foundation and government partners in hundreds of programs to improve the quality of life in metropolitan areas around the world.