Oncology News and Research

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Oncology, meaning bulk, mass, or tumor, and the suffix ''-logy'', meaning "study of") is a branch of medicine that deals with tumors (cancer). A medical professional who practices oncology is an ''oncologist''.

NIH grant for Mount Sinai to study use of inhaled corticosteroids for treatment of sickle cell disease

The Departments of Emergency Medicine and Hematology at the Icahn School of Medicine at Mount Sinai have been awarded a $4 million grant from the National Institutes of Health toward further study of inhaled corticosteroids to treat sickle cell disease in individuals who do not have asthma.

14 Aug 2018

New strategy accelerates, automates process of prototype molecule optimization

The search for new medicinal molecules with predetermined properties is a rather complex, expensive and time-consuming process, especially in oncology.

14 Aug 2018

New method provides a 'big picture' of genetic influences on traits and diseases

Scientists at Johns Hopkins Bloomberg School of Public Health have developed a powerful method for characterizing the broad patterns of genetic contributions to traits and diseases. The new method provides a "big picture" of genetic influences that should be particularly helpful in designing future genetic studies and understanding potential for genetic risk prediction.

14 Aug 2018

Study: Many pediatric brain tumor survivors do not achieve complete independence as adults

In the first study of its kind, St. Jude Children's Research Hospital investigators have found that more than half of pediatric central nervous system tumor survivors do not achieve complete independence as adults.

10 Aug 2018

NCCN releases new treatment guidelines for rare cancers that impact women during pregnancy

The National Comprehensive Cancer Network has released new treatment guidelines for a group of rare cancers that impact women during pregnancy.

10 Aug 2018

Collaboration between Merck and InnoCore could improve biologic drug delivery

Following today’s (Friday 3 August) announcement of Merck and InnoCore’s collaboration, Rahael Maladwala, Pharma Analyst at GlobalData, a leading data and analytics company, offers his view on what this might mean for biologic drug delivery:

10 Aug 2018

Game theory can be used to identify potential flaws in current cancer treatment approaches

Game theory can be utilized to identify potential flaws in current cancer treatment approaches and suggest new strategies to improve outcomes in patients with metastatic cancer, according to a new article published online today by JAMA Oncology.

10 Aug 2018

Patients with chronic lymphocytic leukemia have higher risk of melanoma, shows study

While studying a large group of individuals with chronic lymphocytic leukemia, a Wilmot Cancer Institute scientific team made an important discovery -- these patients had a sizable 600 percent higher risk of melanoma, the most dangerous form of skin cancer.

10 Aug 2018

Researchers study use of MRI-guided focused ultrasound to open blood-brain barrier

In the first such clinical trial in the United States, physician-scientists with the University of Maryland School of Medicine are investigating the use of MRI-guided focused ultrasound to open the blood-brain barrier.

10 Aug 2018

Scientists find new molecular biomarker for gastric cancer

Although immunotherapy is seen as a very promising treatment for cancer, currently only 20 to 30 percent of patients respond positively. Being able to identify the people most likely to benefit from the costly therapy is a Holy Grail for oncologists.

9 Aug 2018

Study finds false negatives in common tests used to determine ROS1 status in lung cancer

Drugs like crizotinib are used to treat patients with ROS1-positive lung cancer. But which patients are ROS1-positive? A University of Colorado Cancer Center study published in the Journal of Thoracic Oncology shows that common laboratory tests used to determine ROS1 status all have inherent limitations that can lead to false-negative results.

9 Aug 2018

RNA and DNA sequencing platform matches broader swath of drugs to late-stage cancer patients

A comprehensive RNA and DNA sequencing platform benefits late-stage and drug-resistant multiple myeloma patients by determining which drugs would work best for them, according to results from a clinical trial published in JCO Precision Oncology in August.

9 Aug 2018

Cleveland Clinic awarded $4.7 million grant to study prevention of cancer-associated blood clots

The National Heart, Lung and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $4.7 million grant to Cleveland Clinic to study the prevention of life-threatening, cancer-associated blood clots.

9 Aug 2018

Gene considered as tumor promoter may also halt development of cancer, shows study

A gene that has for decades been considered a tumor promoter, the PLK1 gene, can also perform the exact opposite function: halting the development of cancer.

9 Aug 2018

Study identifies distinct genetic mutations in appendix cancer that may impact treatment

The rarity of appendix cancer, accounting for less than 1 percent of tumors that originate in the gastrointestinal tract, and the lack of scientific data for this disease means that current treatment guidelines recommend applying therapies to people with appendix cancer that are intended for those with colon cancer.

9 Aug 2018

FDA approves drug for rare, hard-to-treat types of non-Hodgkin lymphoma

The U.S. Food and Drug Administration today approved Poteligeo (mogamulizumab-kpkc) injection for intravenous use for the treatment of adult patients with relapsed or refractory mycosis fungoides or Sézary syndrome after at least one prior systemic therapy.

8 Aug 2018

Nanocellulose fibers can reduce fat absorption, research finds

A novel method of reducing the absorption of fat from the gut has recently been granted a US provisional patent. Researchers have demonstrated that the addition of nanocellulose fibres to the food of animals significantly reduces the amount of ingested fat that reaches the bloodstream.

8 Aug 2018

Researchers use PET tracer to identify ER expression differences in metastatic breast cancer patients

In metastatic breast cancer, prognosis and treatment is largely influenced by estrogen receptor expression of the metastases.

7 Aug 2018

Blood-based test accurately identifies lung cancer patients who could benefit from immunotherapies

Researchers at UC Davis, Genentech and Foundation Medicine are the first to show that a blood-based test to assess tumor mutational burden accurately identifies non-small cell lung cancer (NSCLC) patients who could benefit from immunotherapies called checkpoint inhibitors.

7 Aug 2018

Cocaine relapse is reduced in preclinical model with BDNF administration

Cocaine relapse was significantly reduced in a preclinical model when brain-derived neurotropic factor was applied to the nucleus accumbens deep in the brain immediately before cocaine-seeking behavior, report investigators at the Medical University of South Carolina in an article published online in June 2018 by Addiction Biology.

3 Aug 2018

Oncology News and Research

Further Reading

NIH grant for Mount Sinai to study use of inhaled corticosteroids for treatment of sickle cell disease

New strategy accelerates, automates process of prototype molecule optimization

New method provides a 'big picture' of genetic influences on traits and diseases

Study: Many pediatric brain tumor survivors do not achieve complete independence as adults

NCCN releases new treatment guidelines for rare cancers that impact women during pregnancy

Collaboration between Merck and InnoCore could improve biologic drug delivery

Game theory can be used to identify potential flaws in current cancer treatment approaches

Patients with chronic lymphocytic leukemia have higher risk of melanoma, shows study

Researchers study use of MRI-guided focused ultrasound to open blood-brain barrier

Scientists find new molecular biomarker for gastric cancer

Study finds false negatives in common tests used to determine ROS1 status in lung cancer

RNA and DNA sequencing platform matches broader swath of drugs to late-stage cancer patients

Cleveland Clinic awarded $4.7 million grant to study prevention of cancer-associated blood clots

Gene considered as tumor promoter may also halt development of cancer, shows study

Study identifies distinct genetic mutations in appendix cancer that may impact treatment

FDA approves drug for rare, hard-to-treat types of non-Hodgkin lymphoma

Nanocellulose fibers can reduce fat absorption, research finds

Researchers use PET tracer to identify ER expression differences in metastatic breast cancer patients

Blood-based test accurately identifies lung cancer patients who could benefit from immunotherapies

Cocaine relapse is reduced in preclinical model with BDNF administration

A best-practice guide for laboratory services in oncology trials eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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