Clinical Trial News and Research

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AI VIVO seeks pharma, biotech collaboration partners to advance drug candidates for COVID-19

AI VIVO has announced that it is seeking pharma and biotech collaboration partners to progress therapeutic candidates for COVID-19.

11 May 2020

NIH clinical trial evaluates antiviral plus anti-inflammatory drug for COVID-19

A randomized, controlled clinical trial evaluating the safety and efficacy of a treatment regimen of the investigational antiviral remdesivir plus the anti-inflammatory drug baricitinib for coronavirus disease 2019 (COVID-19) has begun.

8 May 2020

Novel anti-cancer medicine could improve current therapy for ER+ breast cancer

The anti-cancer medicine venetoclax could improve the current therapy for estrogen receptor-positive breast cancer - the most common form of breast cancer in Australia - according to preclinical studies led by Walter and Eliza Hall Institute researchers.

8 May 2020

Olanzapine drug can help manage nausea and vomiting in patients with advanced cancer

Olanzapine, a generic drug used to treat nervous, emotional and mental conditions, also may help patients with advanced cancer successfully manage nausea and vomiting unrelated to chemotherapy.

8 May 2020

Most COVID-19 patients lose sense of smell by the third day, shows study

A University of Cincinnati researcher says a study of COVID-19 patients shows loss of the sense of smell is most likely to occur by the third day of infection with the novel virus. Most of these patients are also experiencing a loss of the sense of taste.

8 May 2020

Predicting the dose for repurposing nitazoxanide in COVID-19

A new study published on the preprint server medRxiv in May 2020 reports a model that could help evolve appropriate dosage protocols for future clinical trials of the repurposed drug nitazoxanide in COVID-19 prevention and treatment. The researchers say, “It was possible to achieve plasma and lung tizoxanide concentrations, using proven safe doses of nitazoxanide, that exceed the EC90 for SARS-CoV-2.”

7 May 2020

Modified dialysis device treats COVID-19

As part of a randomized controlled trial, a team from Lawson Health Research Institute is the first in the world to treat a patient with COVID-19 using a modified dialysis device.

7 May 2020

Antibiotic combined with measurement technology may save time and money in developing new active ingredients

A minimal – and therefore innocuous – dose of an antibiotic coupled with highly sensitive measurement technology could save time and money in the development of new active ingredients.

7 May 2020

Pivotal to support new clinical trial for COVID-19 patients

Pivotal, a European-wide full-service CRO, has announced today that it has been contracted to provide specialized clinical research services in a clinical trial to study the efficacy and safety of hyperimmune plasma, obtained from cured and convalescent COVID-19 patients, in the treatment of hospitalized patients with COVID-19 who are admitted in an acute phase.

7 May 2020

Combination therapy trial to understand the biology, spread, treatment of COVID-19

The HonorHealth Research Institute and HonorHealth announced today the successful enrollment on a novel combination of atovaquone and azithromycin in patients with moderate-to-severe COVID-19 infection.

6 May 2020

New trial platform could help evaluate potential therapies for Parkinson’s disease

Despite 30 years of research, not a single therapy has been found to successfully delay or stop the progression of Parkinson's disease.

6 May 2020

Caffeine consumption can protect against Parkinson’s disease, shows study

Two purines, caffeine and urate, have been associated with a reduced risk of Parkinson's disease (PD) in multiple study groups and populations.

6 May 2020

Cytokine storms created by COVID-19 could be reduced by using blood filter

Cytokine storms created by COVID-19 are causing major organ destruction and death, and for the first time in the United States, when patients begin to show signs of trouble, physicians are replacing the usual filter in a kidney dialysis machine with a filter known to trap these tiny proteins, with the goal of avoiding the devastation.

6 May 2020

COVID-19 infection risk and outcomes explained by the cell receptor genetic variability

Genetic variants in the angiotensin‐converting enzyme 2 (ACE2) receptor, utilized by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) for cell entry, are predicted to either encourage or inhibit interaction with viral proteins and subsequently contribute to genetic risk in coronavirus disease (COVID-19). This is the key finding of a new study available on the preprint server bioRxiv*.

5 May 2020

Study shows lower caffeine, urate levels are inversely linked to Parkinson’s disease

Analysis of participants in the Harvard Biomarkers Study highlights the inverse association between low caffeine consumption and blood urate levels and PD, report scientists in the Journal of Parkinson's Disease.

5 May 2020

Bioactive lipids are key for diagnosis and treatment of cardiac repair after heart attack

Black men and women have higher incidences than whites of developing advanced heart failure following a heart attack.

5 May 2020

A $10 million grant enables expansion of BCG vaccine trial against COVID-19

An A$10 million grant from the Bill & Melinda Gates Foundation will allow the Murdoch Children's Research Institute's clinical trial of the BCG vaccine against COVID-19 to extend to 10,000 healthcare workers across Australia, Spain and The Netherlands.

4 May 2020

AI-based technology could help accelerate clinical trials for glaucoma

The technology, supported by an artificial intelligence (AI) algorithm, could help accelerate clinical trials, and eventually may be used in detection and diagnostics, according to the Wellcome-funded study published today in Expert Review of Molecular Diagnostics.

4 May 2020

New initiative to speed up development and commercialization of COVID-19 testing technologies

UMass Medical School and UMass Lowell will perform a key role in a new National Institutes of Health initiative aimed at speeding innovation, development and commercialization of COVID-19 testing technologies via their Center for Advancing Point of Care Technologies collaboration.

4 May 2020

AHA awards grants to 12 teams for fast-tracked heart and brain health research related to COVID-19

Less than a month after issuing a rapid response call for scientific research proposals for fast-tracked studies of the effects of COVID-19 on the body's cardiovascular and cerebrovascular systems, the American Heart Association has awarded $1.2 million in grants to teams at 12 institutions across the U.S. to begin this unprecedented work.

2 May 2020

Clinical Trial News and Research

AI VIVO seeks pharma, biotech collaboration partners to advance drug candidates for COVID-19

NIH clinical trial evaluates antiviral plus anti-inflammatory drug for COVID-19

Novel anti-cancer medicine could improve current therapy for ER+ breast cancer

Olanzapine drug can help manage nausea and vomiting in patients with advanced cancer

Most COVID-19 patients lose sense of smell by the third day, shows study

Predicting the dose for repurposing nitazoxanide in COVID-19

Modified dialysis device treats COVID-19

Antibiotic combined with measurement technology may save time and money in developing new active ingredients

Pivotal to support new clinical trial for COVID-19 patients

Combination therapy trial to understand the biology, spread, treatment of COVID-19

New trial platform could help evaluate potential therapies for Parkinson’s disease

Caffeine consumption can protect against Parkinson’s disease, shows study

Cytokine storms created by COVID-19 could be reduced by using blood filter

COVID-19 infection risk and outcomes explained by the cell receptor genetic variability

Study shows lower caffeine, urate levels are inversely linked to Parkinson’s disease

Bioactive lipids are key for diagnosis and treatment of cardiac repair after heart attack

A $10 million grant enables expansion of BCG vaccine trial against COVID-19

AI-based technology could help accelerate clinical trials for glaucoma

New initiative to speed up development and commercialization of COVID-19 testing technologies

AHA awards grants to 12 teams for fast-tracked heart and brain health research related to COVID-19

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