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Researchers develop improved process for large-scale electron microscopy to visualize small structures

How are networks of neurons connected to make functional circuits? This has been a long-standing question in neuroscience. To answer this fundamental question, researchers from Boston Children's Hospital and Harvard Medical School developed a new way to study these circuits and in the process learn more about the connections between them.

12 Jan 2021

Researchers identify shorter form of ACE2 that lacks SARS-CoV-2 binding site

A shadow over the promising inhaled interferon beta COVID-19 therapy has been cleared with the discovery that although it appears to increase levels of ACE2 protein - coronavirus' key entry point into nose and lung cells - it predominantly increases levels of a short version of that protein, which the virus cannot bind to.

12 Jan 2021

ARID1A gene in ovarian cancer plays a role in the regulation of metabolism

Mutations that inactivate the ARID1A gene in ovarian cancer increase utilization of the glutamine amino acid making cancer cells dependent on glutamine metabolism, according to a study by The Wistar Institute published online in Nature Cancer.

12 Jan 2021

Study shows COVID-19 pneumonia is different from typical pneumonia

Bacteria or viruses like influenza that cause pneumonia can spread across large regions of the lung over the course of hours. In the modern intensive care unit, these bacteria or viruses are usually controlled either by antibiotics or by the body's immune system within the first few days of the illness.

12 Jan 2021

Researchers develop new technique to more efficiently isolate and identify rare T cells

Scientists from the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a technique that will enable researchers to more efficiently isolate and identify rare T cells that are capable of targeting viruses, cancer and other diseases.

12 Jan 2021

Seed-borne bacterium can lead to complete resistance to a particular pathogen

Rice is the staple food of about half the world's population. The cultivation of the rice plant is very water-intensive and, according to the German aid organization Welthungerhilfe, around 15 per cent of rice is grown in areas with a high risk of drought.

12 Jan 2021

Researchers study the behavior of regulatory T cells to understand periodontal disease

In diseases characterized by bone loss -such as periodontitis, rheumatoid arthritis, and osteoporosis- there is a lot that scientists still don't understand. What is the role of the immune response in the process? What happens to the regulatory mechanisms that protect bone?

12 Jan 2021

Legislation of Dense Breast Notifications has achieved only partial success, indicates study

Little previous research has examined the effects of Dense Breast Notifications (DBNs), but a new study suggests the legislatively required notifications have achieved partial success: women living in states in which in DBNs are mandated had higher rates of being informed about personal breast density and of having had breast density discussions with providers, though rates were low overall.

12 Jan 2021

Discovery of SARS-CoV-2 neutralizing antibodies from a naïve human Ab library

Now, a new preprint research paper published on the bioRxiv server shows how closely the antibodies formed in exposed humans resemble the germline antibody molecules. This could lead to the development of novel therapeutics to counter the pandemic.

12 Jan 2021

Study could help develop new oral drugs for treating muscular dystrophy, heart failure

Cell-derived exosomes are effective in treating disease when mixed with the dominant protein in breast milk and given orally, a new Smidt Heart Institute study of laboratory mice shows.

12 Jan 2021

Researchers identify a new link between seizures and connexin 36 deficiency

For the brain to learn, retain memories, process sensory information, and coordinate body movements, its groups of nerve cells must generate coordinated electrical signals. Disorder in synchronous firing can impair these processes and, in extreme cases, lead to seizures and epilepsy.

12 Jan 2021

Stress during pregnancy could affect the baby's chance of developing multiple diseases

Stress on an expectant mother could affect her baby's chance of developing disease - perhaps even over the course of the child's life, UC researchers have found.

12 Jan 2021

Patient with hypertension or cardiovascular diseases experienced critical disease progression with COVID-19

COVID-19 patients who also suffer from high blood pressure are more likely to fall severely ill with the disease, which also leaves them at greater risk of death.

11 Jan 2021

Study offers data related to physicians' potential liability to use AI in personalized medicine

Physicians who follow artificial intelligence (AI) advice may be considered less liable for medical malpractice than is commonly thought, according to a new study of potential jury candidates in the U.S.

11 Jan 2021

COVID-19 taking a disproportionate toll on female healthcare workers

Women in the healthcare workforce seem to be suffering stress and burnout in the current pandemic situation, disproportionately when compared to men, suggests a new preprint research paper published on the medRxiv server.

11 Jan 2021

Mosaic mutations during embryonic development can cause autism spectrum disorder

Two studies in today's Nature Neuroscience, led by researchers at Boston Children's Hospital, Brigham and Women's Hospital (BWH), and Harvard Medical School (HMS), implicate mosaic mutations arising during embryonic development as a cause of autism spectrum disorder (ASD). The findings open new areas for exploring the genetics of ASD and could eventually inform diagnostic testing.

11 Jan 2021

SARS-CoV-2 exposure in England could be double reported seroprevalence

A new study that recently appeared on the preprint server medRxiv* makes use of a combined method to estimate population exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), taking into account the fact that patients who recover from the infection often do not have circulating antibodies against the virus.

11 Jan 2021

Research News and Research

Researchers develop improved process for large-scale electron microscopy to visualize small structures

Researchers identify shorter form of ACE2 that lacks SARS-CoV-2 binding site

ARID1A gene in ovarian cancer plays a role in the regulation of metabolism

Study shows COVID-19 pneumonia is different from typical pneumonia

Researchers develop new technique to more efficiently isolate and identify rare T cells

Seed-borne bacterium can lead to complete resistance to a particular pathogen

Researchers study the behavior of regulatory T cells to understand periodontal disease

Legislation of Dense Breast Notifications has achieved only partial success, indicates study

Discovery of SARS-CoV-2 neutralizing antibodies from a naïve human Ab library

Study could help develop new oral drugs for treating muscular dystrophy, heart failure

Researchers identify a new link between seizures and connexin 36 deficiency

Stress during pregnancy could affect the baby's chance of developing multiple diseases

Patient with hypertension or cardiovascular diseases experienced critical disease progression with COVID-19

Study offers data related to physicians' potential liability to use AI in personalized medicine

COVID-19 taking a disproportionate toll on female healthcare workers

Mosaic mutations during embryonic development can cause autism spectrum disorder

SARS-CoV-2 exposure in England could be double reported seroprevalence

The mystery of Giglio island’s resistance to COVID-19

UMass Lowell researcher receives NIH support to develop therapies for young people with TBIs

Study: Telehealth use jumped sharply during the first months of pandemic shutdown

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