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Four pancreatic injury safety biomarkers identified and evaluated by PSTC

Critical Path Institute (C-Path) today announced that the Biomarker Qualification Program (BQP) at the Center for Drug Evaluation and Research (CDER) in the U.S. Food and Drug Administration (FDA) issued a Biomarker Letter of Support (LOS) for four pancreatic injury safety biomarkers identified and evaluated by C-Path's Predictive Safety Testing Consortium's (PSTC) Pancreatic Injury Working Group (PIWG).

14 Jun 2023

Connecting the inflammatory dots: Obesity, depression, and Alzheimer's linked by neuroinflammation

Obesity-induced neuroinflammation significantly contributes to the pathophysiology of depression and Alzheimer's disease. Targeting midlife stage for intervention is crucial to potentially prevent Alzheimer's pathology.

13 Jun 2023

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

Synthetic biologists have become increasingly creative in engineering yeast or bacteria to churn out useful chemicals - from fuels to fabrics and drugs - beyond the normal repertoire of microbes.

13 Jun 2023

Mark Cuban's Cost Plus Drug Company projects huge savings over Medicare for generic cancer medications

Researchers reveal significant cost savings when generic oncology drugs are purchased through the Mark Cuban Cost Plus Drug Company.

13 Jun 2023

DYRK1A gene may dictate susceptibility to multiple highly pathogenic coronaviruses

Entry of the SARS-CoV-2 virus into human tissues depends on the activity of a host gene that regulates production of a key viral receptor, according to a study publishing June 13th in the open access journal PLOS Biology by Madison Strine and Craig Wilen of Yale University, US, and colleagues.

13 Jun 2023

Simple juice concentrate from the Japanese plum may reduce cardiovascular disease risk

More than 122 million Americans – about half of the U.S. population ages 20 and older – have high blood pressure, referred to medically as hypertension.

13 Jun 2023

UCL researchers produce first image of the structures that power human cilia

The first image of the structures that power human cilia – the tiny, hairlike projections that line our airways – has been produced by a team involving UCL researchers and could lead to much-needed treatments for people with rare cilial diseases.

13 Jun 2023

Using heart and lung stem cells to better understand how COVID-19 impacts different organs

Researchers have used heart and lung stem cells infected with the virus that causes COVID-19 to better understand how the disease impacts different organs, paving the way for more targeted treatments.

13 Jun 2023

Common laxative prucalopride may be useful as a pro-cognitive treatment in psychiatric conditions

Cognitive deficits accompany mood disorders and other psychiatric conditions, often with debilitating effects.

13 Jun 2023

When COVID meets Candida: exploring the alarming surge of C. auris in Israel

CDC reports an outbreak involving Candida auris (C. auris) in Israel.

13 Jun 2023

Increased risk of T2D in patients linked to low birthweight, study finds

T2D patients with lower birthweight also show higher use of diabetes drugs than those with normal birthweight, and a larger number of comorbidities including high blood pressure, at the time of diagnosis.

13 Jun 2023

Study reveals biologically validated imaging-based evidence of medically induced myelin repair

A decade after UC San Francisco scientists identified an over-the-counter antihistamine as a treatment for multiple sclerosis, researchers have developed an approach to measure the drug's effectiveness in repairing the brain, making it possible to also assess future therapies for the devastating disorder.

13 Jun 2023

Letermovir: A promising breakthrough in CMV prevention for kidney transplant recipients

In a recent article published in the journal JAMA Network, researchers performed a randomized clinical trial (RCT) to demonstrate the noninferiority of letermovir vs. valganciclovir for prophylaxis of cytomegalovirus (CMV) in adult CMV-seronegative kidney transplant recipients (KTRs) who received a kidney from a CMV-seropositive individual.

13 Jun 2023

Metformin shows promising antiviral activity against SARS-CoV-2

Metformin, a widely available oral medication, reduces SARS-CoV-2 viral load by 3.6-fold in outpatient trial, offering a potential treatment option. Ivermectin and fluvoxamine show no significant virologic effect.

12 Jun 2023

Metformin reduces risk of long COVID by over 40%

Researchers discuss whether metformin, ivermectin, or fluvoxamine could reduce the risk of long COVID if administered shortly after infection.

12 Jun 2023

Police drug seizures associated with increase in fatal overdoses

For decades, efforts by police to seize illicit drugs have been a cornerstone strategy for disrupting drug markets and removing drugs from communities. But there's an unintended outcome when opioids are seized, a new study finds - increases in overdoses, including those that are fatal.

12 Jun 2023

Researchers create a new method of studying nano-sized particles

Researchers at Karolinska Institutet have created a new method of studying the smallest bioparticles in the body.

12 Jun 2023

Researchers identify a potential breakthrough in glioblastoma treatment

In a recently published manuscript, Howard Colman, MD, PhD, Jon M. Huntsman Presidential Professor of Neuro-Oncology and co-leader of the Neurologic Cancers Disease Center and the Experimental Therapeutics CCSG program at Huntsman Cancer Institute, identified a potential breakthrough in glioblastoma treatment.

12 Jun 2023

Rice U. postdoctoral fellow explores the link between menopause and Alzheimer’s disease

Two-thirds of the people suffering from Alzheimer's disease are women, yet most research has ignored differences between the sexes.

12 Jun 2023

So-called “orphan” drugs earn pharmaceutical companies as much money as mainstream medicines

Drugs used to treat rare conditions are earning pharmaceutical companies almost as much as those marketed to the general public, according to a researcher at West Virginia University. Sean Tu, a College of Law professor found lucrative so-called "orphan" drugs earn manufacturing tax credits, have longer patent exclusivities and face easier Food and Drug Administration review.

12 Jun 2023

Drugs News and Research

Four pancreatic injury safety biomarkers identified and evaluated by PSTC

Connecting the inflammatory dots: Obesity, depression, and Alzheimer's linked by neuroinflammation

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

Mark Cuban's Cost Plus Drug Company projects huge savings over Medicare for generic cancer medications

DYRK1A gene may dictate susceptibility to multiple highly pathogenic coronaviruses

Simple juice concentrate from the Japanese plum may reduce cardiovascular disease risk

UCL researchers produce first image of the structures that power human cilia

Using heart and lung stem cells to better understand how COVID-19 impacts different organs

Common laxative prucalopride may be useful as a pro-cognitive treatment in psychiatric conditions

When COVID meets Candida: exploring the alarming surge of C. auris in Israel

Increased risk of T2D in patients linked to low birthweight, study finds

Study reveals biologically validated imaging-based evidence of medically induced myelin repair

Letermovir: A promising breakthrough in CMV prevention for kidney transplant recipients

Metformin shows promising antiviral activity against SARS-CoV-2

Metformin reduces risk of long COVID by over 40%

Police drug seizures associated with increase in fatal overdoses

Researchers create a new method of studying nano-sized particles

Researchers identify a potential breakthrough in glioblastoma treatment

Rice U. postdoctoral fellow explores the link between menopause and Alzheimer’s disease

So-called “orphan” drugs earn pharmaceutical companies as much money as mainstream medicines

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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