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Spinal Muscular Atrophy patients are at higher risk of developing fatty liver disease

An international study has discovered that people living with the neurodegenerative condition Spinal Muscular Atrophy (SMA) are at higher risk of developing fatty liver disease, suggesting that SMA patients may face additional health problems over time.

17 Jul 2024

Immune cell inflammation may be responsible for some severe symptoms in lysosomal storage diseases

Researchers at The Hospital for Sick Children (SickKids) have found that inflammation in an immune cell may be responsible in part for some severe symptoms in a group of rare genetic conditions called lysosomal storage diseases (LSDs).

12 Jul 2024

Accelerate Your Research: Dispen3D Harnesses the Power of 3D Models

Dispen3D is setting new standards in single-cell biology, enabling researchers to conduct high-precision experiments that drive advancements in drug discovery, personalized medicine, and regenerative therapies.

From SEED Biosciences 12 Jul 2024

Aging aggravates liver fibrosis in Down Syndrome, new study finds

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 12, entitled, "Aging exacerbates oxidative stress and liver fibrosis in an animal model of Down Syndrome."

10 Jul 2024

Click-like chemistry enables rapid development of LNPs for enhanced mRNA delivery

Imagine a scenario where a skilled hacker must upload critical software to update a central server and thwart a potentially lethal virus from wreaking havoc across a vast computer network.

10 Jul 2024

Researchers receive $2 million in grants to advance studies on age-related cognitive impairment

Two University of Oklahoma researchers have been awarded more than $2 million in grants from the Hevolution Foundation to further their studies on age-related cognitive impairment, with an emphasis on improving "health span," or the number of years a person remains healthy.

9 Jul 2024

Omics-based approaches to age-related macular degeneration

A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 12, entitled, "Aging retinal pigmented epithelium: omics-based insights into vision decline."

9 Jul 2024

Small molecule discovery offers hope for treatment of Angelman syndrome

Angelman syndrome is a rare genetic disorder caused by mutations in the maternally-inherited UBE3A gene and characterized by poor muscle control, limited speech, epilepsy, and intellectual disabilities.

8 Jul 2024

Ribosomes and ZAK protein spur the cell's initial response to UV radiation damage

In a recent study, researchers at Johns Hopkins Medicine suggest the cell's messenger RNA (mRNA) - the major translator and regulator of genetic material - along with a critical protein called ZAK, spur the cell's initial response to UV radiation damage and play a critical role in whether the cell lives or dies.

2 Jul 2024

Study links common infections to enhanced COVID-19 defense in children

Analyzing nasal swabs taken during the pandemic, researchers at Yale School of Medicine suggest that the frequent presence of other viruses and bacteria may have helped to protect children from the worst effects of COVID-19 by boosting their immune systems.

1 Jul 2024

High-resolution real-time imaging reveals early developmental processes in quail embryos

Researchers at The University of Queensland have for the first time captured images and video in real time of early embryonic development to understand more about congenital birth defects.

1 Jul 2024

LJI study details measles virus neutralization

What happens when measles virus meets a human cell? The viral machinery unfolds in just the right way to reveal key pieces that let it fuse itself into the host cell membrane.

28 Jun 2024

Study identifies mechanism that impedes the effectiveness of melanoma therapies

In many cases of malignant melanoma, the effect of targeted treatment is lost over time. A research team from UZH and USZ has now discovered that a factor secreted by tumor cells is responsible for the resistance.

27 Jun 2024

Cell division's hidden safety mechanism may influence cancer growth

Before a cell commits fully to the process of dividing itself into two new cells, it may ensure the appropriateness of its commitment by staying for many hours - sometimes more than a day - in a reversible intermediate state, according to a discovery by researchers at Weill Cornell Medicine. Their revelation of this fundamental feature of biology includes details of its mechanisms and dynamics, which may inform the development of future therapies targeting cancers and other diseases.

27 Jun 2024

Study provides resource for investigating diabetes-linked transcription factors

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells. Published in the journal Nature Communications, the study revealed common and tissue-specific molecular pathways regulated by HNF4A and HNF1A, two proteins that possess important functions governing the development and function of the pancreas and liver.

26 Jun 2024

Pentraxin 3 as a predictor of advanced fibrosis and carotid intima-media thickness in MAFLD patients

Metabolic-associated fatty liver disease (MAFLD) may increase the risk of cardiovascular events. In this study, we assessed the predictive value of pentraxin 3 (PTX3) for severe fibrosis and carotid intima-media thickness (CIMT) in patients with MAFLD.

25 Jun 2024

Association of HLA-G*0104N allele with increased risk of recurrent pregnancy loss in Kashmiri population

HLA-G gene harbors certain polymorphic variations that can potentially impact its biological activity, and therefore, may confer a risk for recurrent pregnancy loss (RPL).

25 Jun 2024

Multi-regional sampling uncovers hidden complexity in liver cancer

A study led by clinician-scientists and scientists from the National Cancer Centre Singapore (NCCS) and A*STAR's Genome Institute of Singapore (GIS) and funded by the National Research Foundation Singapore (NRF) has discovered unexpected molecular heterogeneity even within the same liver tumors. More than 40% of HCC harbors more than one molecular subtype within the same tumor and in these, the clinical outcomes for the patients are best predicted by the most aggressive subtype.

25 Jun 2024

DiffPALM: Advancing protein interaction prediction with AI and language models

Proteins are the building blocks of life, involved in virtually every biological process. Understanding how proteins interact with each other is crucial for deciphering the complexities of cellular functions, and has significant implications for drug development and the treatment of diseases.

24 Jun 2024

Dietary sucrose modulates lithium's regulatory activity in Drosophila

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 11, entitled, "Dietary sucrose determines the regulatory activity of lithium on gene expression and lifespan in Drosophila melanogaster."

24 Jun 2024

Cell Biology News and Research

Spinal Muscular Atrophy patients are at higher risk of developing fatty liver disease

Immune cell inflammation may be responsible for some severe symptoms in lysosomal storage diseases

Accelerate Your Research: Dispen3D Harnesses the Power of 3D Models

Aging aggravates liver fibrosis in Down Syndrome, new study finds

Click-like chemistry enables rapid development of LNPs for enhanced mRNA delivery

Researchers receive $2 million in grants to advance studies on age-related cognitive impairment

Omics-based approaches to age-related macular degeneration

Small molecule discovery offers hope for treatment of Angelman syndrome

Ribosomes and ZAK protein spur the cell's initial response to UV radiation damage

Study links common infections to enhanced COVID-19 defense in children

High-resolution real-time imaging reveals early developmental processes in quail embryos

LJI study details measles virus neutralization

Study identifies mechanism that impedes the effectiveness of melanoma therapies

Cell division's hidden safety mechanism may influence cancer growth

Study provides resource for investigating diabetes-linked transcription factors

Pentraxin 3 as a predictor of advanced fibrosis and carotid intima-media thickness in MAFLD patients

Association of HLA-G*0104N allele with increased risk of recurrent pregnancy loss in Kashmiri population

Multi-regional sampling uncovers hidden complexity in liver cancer

DiffPALM: Advancing protein interaction prediction with AI and language models

Dietary sucrose modulates lithium's regulatory activity in Drosophila

Improve fermentation and cell culture performance with real-time gas analysis eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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